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Rapid Access to Free Phenols by Photocatalytic Acceptorless Dehydrogenation of Cyclohexanones at Room Temperature
  • Lin Min,
  • Jia-Ni Lin,
  • Wei Shu
Lin Min
Southern University of Science and Technology
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Jia-Ni Lin
Southern University of Science and Technology
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Wei Shu
Southern University of Science and Technology

Corresponding Author:shuw@sustech.edu.cn

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Abstract

Phenols are ubiquitous substructures in natural products and bioactive compounds. However, practical methods for the direct construction of phenols under mild conditions remains challenging. Herein, a photocatalytic acceptorless dehydrogenative aro-matization of cyclohexanones or cyclohexenones at room temperature has been developed. The reaction features the visible-light and cobalt co-catalyzed sequential dehydrogenation of in-situ formed enol silyl ethers, which are regarded as a challenging process. This operationally simple method enables the synthesis of a series of phenols with diverse substitution patterns from cyclohexanones or cyclohexenones. Moreover, diverse substituted 1,2-, 1,3-, and 1,4-benzenediols were obtained from cyclo-hexanediones, providing a general and straightforward method for the synthesis of phenols from simple starting materials un-der mild conditions
08 Jun 2023Reviewer(s) Assigned
10 Jun 2023Review(s) Completed, Editorial Evaluation Pending
10 Jun 2023Editorial Decision: Revise Minor
19 Jun 20231st Revision Received
21 Jun 2023Assigned to Editor
21 Jun 2023Submission Checks Completed
21 Jun 2023Review(s) Completed, Editorial Evaluation Pending
21 Jun 2023Editorial Decision: Accept