Introduction:To prevent acute or chronic allograft rejection, recipients of kidney transplants are needed to take immunosuppressive for the rest of their lives. However, their compromised immune system put them at risk for opportunistic infections as well1. Infection with the varicella-zoster virus (VZV) is an unusual in recipients of kidney transplants at a frequency rate from 1% to 11%, but the severity is more significant in transplant patients compared to the overall population 2, 3. Fever and a self-limiting rash on the skin and occasionally the mucosa may be the present symptoms of varicella infection. Additionally observed symptoms include headache, malaise, and appetite loss. The rash starts off as macules, quickly develops into papules and then goes through a vesicular stage and crusts over the lesions. After one to two weeks, crusts flake off4. Disseminated herpes zoster (HZ) in kidney transplant recipients can result in a very high overall mortality rate of up to 30% 5.Here we describe a 23-year-old male patient with a history renal transplant who presented to the emergency department with complaint of high grade fever, chills and generalized rash for 5 days.