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The Efficacy of COVID-19 Vaccines in People with Obesity: A Systematic Review and Meta-analysis
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  • Xiaodan Ou,
  • Jialin Jiang,
  • Bingqian Lin,
  • Qinyu Liu,
  • Wei LIN,
  • Gang Chen,
  • Junping Wen
Xiaodan Ou
Fujian Medical University

Corresponding Author:1599235788@qq.com

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Jialin Jiang
Fujian Provincial Hospital
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Bingqian Lin
Fujian Medical University
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Qinyu Liu
Fujian Medical University
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Wei LIN
Fujian Provincial Hospital
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Gang Chen
Fujian Provincial Hospital
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Junping Wen
Fujian Medical University
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Abstract

Background: COVID-19 vaccine is critical in preventing SARS-CoV-2 infection and transmission. However, obesity’s effect on immune responses to COVID-19 vaccines is still unknown. Methods: We performed a meta-analysis of the literature and compared immune responses to COVID-19 vaccines among persons with and without obesity. We used Pubmed, Embase, Web of Science, and Cochrane Library to identify all related studies up to April 2022. The Stata.14 software was used to analyze the selected data. Results: Totally, 11 studies were included in the present meta-analysis. Five of them provided absolute values of antibody titers in the obese group and non-obese group. Overall, we found that the obese population was significantly associated with lower antibody titers (SMD = -0.228, 95% CI (-0.437, -0.019), P<0.001) after COVID-19 vaccination. Significant heterogeneity was present in most pooled analyses but was reduced after subgroup analyses. No publication bias was observed in the present analysis. The Trim and Fill method did not change the results in the primary analysis. Conclusion: The present meta-analysis suggested that obesity was significantly associated with decreased responses to SARS-CoV-2 vaccines. Future studies should be performed to unravel this relationship to prevent COVID-19 infection and transmission.
09 Nov 2022Submitted to Influenza and other respiratory viruses
10 Nov 2022Submission Checks Completed
10 Nov 2022Assigned to Editor
15 Nov 2022Editorial Decision: Revise Minor
20 Nov 20221st Revision Received
22 Nov 2022Submission Checks Completed
22 Nov 2022Assigned to Editor
22 Nov 2022Editorial Decision: Revise Minor
22 Nov 20222nd Revision Received
23 Nov 2022Submission Checks Completed
23 Nov 2022Assigned to Editor
23 Nov 2022Editorial Decision: Accept