Background: Equine sinonasal disorders are significant diseases whose investigation and treatment have undergone significant changes over the past decade. No large study has described the signalments, pre-referral management, or the clinical and nasal endoscopic findings in such cases referred for advanced imaging and treatment. Objectives: Report the signalments, pre-referral management, and the clinical and nasal endoscopic findings of cases with sinonasal disease referred for advanced imaging and treatment. Study design: Retrospective case series. Methods: Data were collected from 19 equine hospitals on cases of sinonasal disease they had examined, all of which had undergone computed tomographic (CT) imaging. Results: 1600 cases met the requirements for the study, including 1457 cases of unilateral and 143 cases of bilateral (sinonasal disease) sinusitis. Most were chronic disorders with a mean duration of 17.9 weeks (s.d. 34.6 weeks), and 96 cases were over 12 months duration. The most common antimicrobials administered pre-referral were potentiated sulphonamides, followed by doxycycline and procaine penicillin. Pre-referral surgical treatments included maxillary cheek tooth extraction (n=234 teeth), sinoscopy (11.8% of cases), nasofrontal sinus osteotomy (5.2%) and maxillary sinus osteotomy (3.6%). Nasal airflow was obstructed in 14.9% of cases, and facial swelling was present in 26.9% of cases. Nasal endoscopy showed exudate at the sinonasal ostium in 65.8% of cases, and abnormalities, including inspissated exudate, sequestra and sinonasal fistulae, were present in the middle meatus in 44.6% of cases. Multivariable analysis showed the presence of the following variables at presentation were significantly associated with a decreased chance of complete cure: age greater than 12 years, sinonasal disease of greater than 8 weeks duration, prior nasofrontal sinusotomy, presence of facial swelling, epiphora, or bilateral nasal discharge. Main limitations: This was a retrospective study with complete data unavailable for some cases.