Introduction: Recently, a novel non-thermal ablation modality, Pulse Field Ablation (PFA), has been introduced in clinical practice. Case report: Because there were multiple recurrences of ischemic stroke despite adequate anticoagulant therapy , a 64-year-old male was admitted to AF PFA and concomitant left atrial appendage (LAA) closure. An intense smoke effect was detected in the LAA and a cerebral protection device (CPD) was positioned. Catheter AF PFA and LAA closure were performed. One little thrombus had been collected into the CPD at the end of procedure. Conclusion: Combined procedure seems to be safe and feasible.