Hypersensitivity reaction (HSR) to cisplatin can result in discontinuation of chemoradiotherapy in patients with head and neck squamous cell carcinoma (HNSCC). We present a nasopharyngeal carcinoma patient with cisplatin hypersensitivity successfully treated with cisplatin-desensitization. Desensitization therapy may be safe and beneficial in patients with HNSCC who develop HSR to cisplatin.