A supply and temperature fluctuation compensation technique is proposed to solve the gain fluctuation of the residual voltage dynamic amplifier used in pipeline analog-to-digital converter (ADC). Combining slave amplifier with the positive temperature coefficient (PTAT) voltage generation circuit, the gain of the amplifier under different temperature is calibrated adaptively without any complex hardware. At the same time, PTAT can also compensate the fluctuation voltage of power supply then the voltage gain of the amplifier is kept. The design is simulated with 40nm process, the voltage gain variation is less than 1.9% in -40℃~80℃ and 1.4% at the supply voltage range of 1.05V to 1.15V.