Regular follow-up of patients with cardiovascular implantable electronic devices (CIEDs) is a necessary part to optimize the CIED system performance and longevity, which can assess the outcome of CIED, its working conditions and the timely identification of device dysfunction and arrhythmias. Traditional follow-up includes in-person evaluation and remote monitoring. With the development of the 5G cloud support platform, the “5G Cloud Follow-up APP” was designed to realize remote programming of CIEDs, thereby realizing emergency intervention for patients and supplementing deficiencies of traditional follow-up methods. We summarize the utilization, safety, and implications of CIED remote programming.