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Left atrial functional measurements utility in predicting long-term risk of atrial fibrillation after isolated CABG
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  • Mikkel Ravn Dyhr,
  • Søren Lindberg,
  • Flemming Olsen,
  • daniel modin,
  • Thomas Fritz-Hansen,
  • Sune Pedersen,
  • Allan Iversen,
  • Søren Galatius,
  • Thomas Jespersen,
  • Rasmus Møgelvang,
  • Tor Biering-Sørensen
Mikkel Ravn Dyhr
Gentofte Hospital

Corresponding Author:mikkeldyhr@gmail.com

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Søren Lindberg
Gentofte Hospital
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Flemming Olsen
Gentofte Hospital
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daniel modin
Gentofte Hospital
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Thomas Fritz-Hansen
Gentofte Hospital
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Sune Pedersen
Gentofte Hospital
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Allan Iversen
Gentofte Hospital
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Søren Galatius
Bispebjerg Hospital
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Thomas Jespersen
Kobenhavns Universitet
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Rasmus Møgelvang
Kobenhavns Universitet
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Tor Biering-Sørensen
Gentofte Hospital
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Abstract

Abstract Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia following coronary artery bypass grafting (CABG). We hypothesized that measures of left atrial (LA) function would be useful in predicting AF in patients undergoing CABG. Methods and Results In the study, 611 patients were included after CABG. All patients had echocardiograms performed preoperatively and LA functional measurements were assessed. These measurements were LA maximum volume index (LAVmax), LA minimum volume index (LAVmin) and LA emptying fraction (LAEF). The endpoint was AF occurring >14 days after surgery. During the follow-up period of a median of 3.7 years, 52 (9%) developed AF. The mean age was 67 years, 84% were male and the average left ventricle ejection fraction was 50 %. No differences were observed between the patients developing AF and those who did not develop AF. No functional LA measurements were significant predictors of AF in the whole CABG population. However, in patients with normal-sized LA (n=532, events: 49), both LAEF and LAVmin were univariable predictors of AF. When the functional measurements were adjusted for the CHADS 2 score, both LAVmin (HR=1.07 (1.01-1.13), p=0.014 ) and LAEF (HR: 1.02 (1.00-1.03, p= 0.023)), remained significant predictors. Conclusion No echocardiographic measurements were significant predictors of AF after CABG. In patients with a normal LA size, LAVmin as well as LAEF were significant predictors of AF. Keywords: atrial fibrillation; cardiac surgery; left atrium; echocardiography
31 Mar 2022Submitted to Echocardiography
31 Mar 2022Submission Checks Completed
31 Mar 2022Assigned to Editor
05 Apr 2022Reviewer(s) Assigned
23 May 2022Review(s) Completed, Editorial Evaluation Pending
24 May 2022Editorial Decision: Revise Major
27 May 20231st Revision Received
01 Jun 2023Submission Checks Completed
01 Jun 2023Assigned to Editor
01 Jun 2023Reviewer(s) Assigned
05 Jun 2023Review(s) Completed, Editorial Evaluation Pending
06 Jun 2023Editorial Decision: Accept