loading page

Autologous recovery with chromosomal abnormalities after unrelated umbilical cord blood transplantation with myeloablative conditioning in a case of pediatric acute lymphoblastic leukemia
  • +6
  • Yoshinori Uchihara,
  • Itaru Kato,
  • Ryo Hanaki,
  • Satoshi Saida,
  • Shotaro Iwamoto,
  • Katsutsugu Umeda,
  • Hidefumi Hiramatsu,
  • Souichi Adachi,
  • Junko Takita
Yoshinori Uchihara
Graduate School of Medicine, Kyoto University

Corresponding Author:uchihara021@kuhp.kyoto-u.ac.jp

Author Profile
Itaru Kato
Graduate School of Medicine, Kyoto University
Author Profile
Ryo Hanaki
Mie Universities Graduate School of Medicine
Author Profile
Satoshi Saida
Graduate School of Medicine Kyoto University
Author Profile
Shotaro Iwamoto
Mie University Graduate School of Medicine
Author Profile
Katsutsugu Umeda
Graduate School of Medicine, Kyoto University
Author Profile
Hidefumi Hiramatsu
Graduate School of Medicine, Kyoto University
Author Profile
Souichi Adachi
Graduate School of Medicine, Kyoto University
Author Profile
Junko Takita
Graduate School of Medicine, Kyoto University
Author Profile

Abstract

Detailed case reports of autologous recovery of hematopoiesis after hematopoietic stem cell transplantation with myeloablative conditioning (MAC) are scarce. We present a rare case of a 3-year-old male with relapsed KMT2A-rearranged acute lymphoblastic leukemia (ALL) who experienced autologous recovery following secondary engraftment failure after cord blood transplantation (CBT) with MAC. Similar to previous reports, we detected unusual chromosomal abnormalities, which differed at each bone marrow examination. He remains alive without relapse of ALL 12 months after CBT. As the rate of recurrence or late occurrence of secondary malignant neoplasm remains unclear, careful follow-up is required, especially in pediatric patients.