Objectives: Uterine ischemia, often encountered in clinical settings, poses a significant risk during transplantation due to prolonged ischemic processes. This study aims to evaluate the potential efficacy of iloprost in reducing uterine ischemia-reperfusion (I/R) injury. Design: Experimental study. Setting: Adiyaman University Experimental Animal Production and Research Center. Population or Sample: Thirty-two 10-week-old female Sprague Dawley rats, weighing 280–300 g, were divided into four groups: Sham, Ischemia (I), Ischemia-Reperfusion (I/R), and I/R + Iloprost. Methods: The ischemia group underwent 3 hours of ischemia. The I/R group experienced 3 hours of ischemia followed by 3 hours of reperfusion. In the I/R + Iloprost group, iloprost was administered intravenously during the first hour of reperfusion. Histopathological and biochemical evaluations, including malondialdehyde (MDA) and glutathione (GSH) analyses, were conducted. Main Outcome Measures: Histological examination and levels of oxidative stress markers (MDA, GSH). Results: Inflammation and vascular occlusion were severe in the ischemia group and moderate in the I/R group, whereas these were absent in the Sham and I/R + Iloprost groups. GSH levels decreased significantly in the I/R group, while MDA levels peaked in the ischemia group. Iloprost administration mitigated these changes. Conclusion: Iloprost demonstrates protective properties against I/R-induced tissue damage in rat uterine models, suggesting its potential clinical relevance in uterine transplantation. Keywords: ischemia-reperfusion injury, iloprost, uterine surgery, oxidative stress, rat model.

ABSTRACT Background: The mandible, the largest and strongest bone in the face, is the only bone in the skull that does not have a sutural joint. Before starting surgical procedures and clinical approaches, it is necessary to know the anatomy of this region well. Materials and methods: It is a radiology-based morphometric study in which retrospectively scanned images of adult individuals in the 20-50 age range, whose results are normally reported using CT (Conical Beam Computed Tomography) {n=212}. Tomographic images, photographed with Planmeca ProMax3DMid ProFace brand CBCT device, was examined using the Planmeca Romexis 4.6.2.R licensed program. Mandibular incisure angle and gonial angle of the mandible were measured from those images. Gender and age-related comparisons were performed. Results: In all groups, the relationship between the right incisure angle and the right gonial angle was determined as a weak positive relationship, but was found to be statistically significant. The Gonial angle is larger in females on both sides of the jaw than in males. In the study of changes in correlation between mandibular incisure and gonial angle depending on age groups, a statistically significant positive correlation was found in the group that we can call young adults, while a significant difference was not observed in the middle age group and the group that we can call old age. Conclusions: Age and gender-based reference values of gonial angle of mandible and mandibular incisure angle were determined. It is the first study in the literature in which the size and shape of the Incisure angle is evaluated on a cross-population and gender basis. We believe that these angles will have many benefits from a clinical point of view.