We report the case of a 12-year-old girl, who presented with floaters and a white-to-cream peripheral retinal mass in her left eye. No intrinsic calcifications in B-scan ultrasonography and CT scan of the orbits were present and MRI showed a homogenously enhancing peripheral retinal mass with restricted diffusion. Due to close contact with puppies, the patient was initially treated for ocular toxocariasis. However, one month later she developed anterior chamber seeding and anterior chamber tap showed group E retinoblastoma (RB). This case underlines that RB may occur in older ages with atypical manifestations, such as uveitis and absence of calcifications.