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LEVEL OF MATERNAL ANTIBODIES AGAINST RESPIRATORY SYNCYTIAL VIRUS (RSV) NUCLEOPROTEIN AT BIRTH AND RISK OF RSV VERY-SEVERE LOWER RESPIRATORY TRACT INFECTION
  • +9
  • Matthieu RECEVEUR,
  • Michele Ottmann,
  • Jean-Marc Reynes,
  • Jean-François Eleouet,
  • Marie Galloux,
  • Aurore Receveur,
  • Dominique Ploin,
  • Sylvie Fiorini,
  • Nathalie Rivat,
  • Martine Valette,
  • Bruno Lina,
  • jean-sebastien casalegno
Matthieu RECEVEUR
Hospices Civils de Lyon

Corresponding Author:matthieu.receveur@gmail.com

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Michele Ottmann
Université de Lyon, Université Lyon 1
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Jean-Marc Reynes
Université de Lyon
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Jean-François Eleouet
Université Paris-Saclay
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Marie Galloux
Université Paris-Saclay
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Aurore Receveur
Pacific Community
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Dominique Ploin
Hospices Civils de Lyon
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Sylvie Fiorini
Université de Lyon
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Nathalie Rivat
Université de Lyon
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Martine Valette
Hospices Civils de Lyon
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Bruno Lina
Université de Lyon, Université Lyon 1
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jean-sebastien casalegno
Hospices Civils de Lyon, National Influenza Centre (South of France)
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Abstract

Background: The nucleoprotein (N protein) of respiratory syncytial virus (RSV) is a candidate antigen for new RSV vaccine development. The aim of the present study was to investigate the association between maternal antibody titers against the RSV N protein at birth and the newborns’ risk of developing very-severe lower respiratory tract infection (VS-LRTI). Methods: In this single-center prospective cohort study, 578 infants born during the RSV epidemic season in France were included. Among these, 36 were hospitalized for RSV VS-LRTI. A generalized linear model was used to test the occurrence of a VS-LRTI in function of sex, mode of delivery, parity of the mother, type of pregnancy, date of birth in relation to the peak of the epidemic, and antibody titer against N protein. Results: All cord blood samples had detectable antibodies against N protein. The mean titers were significantly lower in newborns with risk factors for RSV severe LRTI (preterm infants, birth before the peak epidemic, multiparous mother). There was no association between antibody titer against the N protein and a protection against VS-LRTI. Conclusions The present study found that transfer of maternal antibodies against the RSV N protein may not provide a significant immune protection early in infancy. Clinical Trials Registration. NCT04144816.
03 Mar 2022Submitted to Influenza and other respiratory viruses
04 Mar 2022Submission Checks Completed
04 Mar 2022Assigned to Editor
27 Mar 2022Reviewer(s) Assigned
12 May 2022Review(s) Completed, Editorial Evaluation Pending
12 May 2022Editorial Decision: Revise Minor
15 Jun 20221st Revision Received
22 Jun 2022Submission Checks Completed
22 Jun 2022Assigned to Editor
24 Jun 2022Editorial Decision: Accept