Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) are an heterogeneous subgroup of rare neoplasms. Triple componed MiNEN associating neuroendocrine tumor, adenocarcinoma and squamous cell carcinoma are rarely described in the literature. Here we present the unique case of a 56-year-old women with neuroendocrine tumor, adenocarcinoma and squamous cell carcinoma of the duodenum