Kaposiform hemangiendothelioma usually occurs in children under two years of age and develops thrombocytopenia secondary to sequestration of platelets within (Kasabach-Merritt phenomenon) and is complicated by secondary consumption of fibrinogen and clotting factors. SARS-CoV-2 produces cutaneous endothelitis as a direct effect of the presence of the virus and the host inflammatory response. We describe an 8-month-old boy with leukemia and SARS-CoV-2 infection who developed Kasabach-Merritt phenomenon, coagulopathy, and intestinal involvement. Given the emerging evidence of endothelial and vascular involvement in COVID-19, the development of tests to detect vascular injury may be critical to guide the use of new therapeutic strategies.