One of the challenges compounding the complexity of reoperative cardiac surgery are the surgical adhesions, which can be responsible for adverse intraoperative events. In such situations implantation of a substitute neo-pericardium has become a frequently used solution for avoiding injuries to the heart and great vessels, with rising numbers of reoperations. The pericardium can be reconstructed using biological (heterologous or autologous) or synthetic material, each having their pros and cons. In this report we present a case of relapsing constrictive pericarditis after implantation of expanded polytetrafluoroethylene neo-pericardium (GORE®). A highly differentiated algorithm and a careful preoperative review of indication is recommended in order to plan the optimal method of pericardioplasty, taking into account the pros and cons of each available material.