Objective : To analyze the application value of fast-track anesthesia in percutaneous occlusion of patent foramen ovale under transesophageal echocardiography. Methodology: 60 cases of patients with patent foramen ovale were randomized into two groups to receive either fast-track anesthesia(Group R) or conventional anesthesia(Group S).Record MAP and HR before anesthesia (T0), tracheal intubation (T1), start of surgery (T2), end of surgery (T3), exit anesthesia recovery room (PACU) (T4), as well as the operation time, anesthesia time , Recovery time of extubation, PACU stay time, recovery period agitation score, pain score VAS out of the anesthesia recovery room (PACU), incidence of adverse reactions. Results: There was no statistically significant difference in the anesthesia time and operation time between the two groups, MAP and HR before and after anesthesia between the two groups were not statistically significant different. There was statistically significant difference in recovery of spontaneous breathing, extubation time, PACU stay time, postoperative restlessness score,and incidence of adverse reactions. Conclusion: Fast-track anesthesia in percutaneous transcatheter closure of patent foramen ovale under transesophageal echocardiography can provide faster recovery of spontaneous breathing, earlier extubation time, shorter PACU stay time, lower postoperative restlessness score, lower incidence of adverse reactions.