We reported 24 years old Nepalese male who presented with epigastric pain and jaundiced found to have pancreatic and liver abscess suspected by abdominal CT scan and MRI, that confirmed later on by EUS-FNA with pus smear and PCR came for acid-fast bacilli. The patient responded remarkably to ATT.

Opportunistic infections are common in human immunodeficiency virus (HIV)-infected patients. Co-infections with Cryptococcus neoformans together with Mycobacterium and Pneumocystis jiroveci pneumonia (PCP) are rare, and typically occur in immunocompromised individuals, particularly AIDS patients.