We describe the case of a patient with a diagnosis of rheumatoid arthritis experiencing a mucocutaneous delayed reaction to golimumab. Anyway, there is no consensus regarding the best management of delayed reactions to biologics. Excluding allergic cross-reactivity or sensitization, we finally tested adalimumab by a graded challenge.

The role of Immunotherapy in Chronic Urticaria is unclear, except for isolated circumstances. Hymenoptera sting causes acute urticaria and no report of CU after Hymenoptera sting can be found in the literature. We describe a case of onset of CU after multiple wasp stings that remitted during venom immunotherapy.