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Relationship Between dominant-frequencies/rotors and Low-voltage Areas Using an Advisor HD Grid Mapping Catheter after Pulmonary Vein Isolation of Non-paroxysmal Atrial Fibrillation
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  • Koji Kumagai,
  • Yuki Kurose,
  • Tsukasa Sato,
  • Takenori Sumiyoshi,
  • Minoru Yambe,
  • Tatsuya Komaru
Koji Kumagai
Tohoku Medical and Pharmaceutical University

Corresponding Author:kkumagai4917@yahoo.co.jp

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Yuki Kurose
Tohoku Medical and Pharmaceutical University
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Tsukasa Sato
Tohoku Medical and Pharmaceutical University
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Takenori Sumiyoshi
Tohoku Medical and Pharmaceutical University
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Minoru Yambe
Tohoku Medical and Pharmaceutical University
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Tatsuya Komaru
Tohoku Medical and Pharmaceutical University
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Abstract

Background This study aimed to evaluate the relationship between dominant frequencies (DFs)/rotors and low-voltage areas (LVAs) using the Advisor HD grid (HDG) after pulmonary vein isolation (PVI) in non-paroxysmal atrial fibrillation (AF). Methods A total of 73 non-paroxysmal AF patients were prospectively investigated. After pulmonary vein isolation (PVI), an online real-time phase mapping system was used to detect the location of rotors with critical non-passively activated ratios (%NPs) of≧50% in each LA segment, and high-DFs of ≧7Hz were simultaneously mapped. After recovering sinus rhythm, LVAs (<0.5mV) were mapped using the HDG. Results Sixty-eight of 73 (93.2%) AF patients had minimum to mild LVAs (<10%) regardless of an enlarged LAD and LA volume (45±6.1mm and 142±30ml). There were no significant differences in the max and mean DF values and %NPs between the patients with and without recurrent AF/AT (atrial tachycardia). However, LVAs were significantly greater in the patients with AF/AT than in those without (6.4±8.0% vs. 2.5±2.6% P=0.003). Furthermore, the number of high-DF sites overlapping with LVAs was significantly greater in the patients with AF/AT than in those without (0.5±0.8 vs. 0.2±0.7, P=0.019). The AF/AT freedom off anti-arrhythmic drugs after the PVI was significantly lower in the patients with high-DFs sites overlapping with LVAs than in those without during 11.6±0.8 months of follow-up (35.7% vs. 69.5%, p=0.021). Conclusions High-DF sites overlapping with LVAs detected accurately by the HDG, regardless of whether a minimum to mild extent, might be more selective targets after a PVI in non-paroxysmal AF patients.