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Combined effect of hygienic and polygenic risk scores in children with allergic rhinitis
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  • Soo-Jong Hong,
  • Eom Ji Choi,
  • Kun Baek Song,
  • Eun Young Baek,
  • Min Jee Park,
  • Ji-Sun Yoon,
  • Sungsu Jung,
  • Si Hyeon Lee,
  • Mi-Jin Kang,
  • Hea Young Oh,
  • So-Yeon Lee,
  • Kang Seo Park
Soo-Jong Hong
Asan Medical Center Children's Hospital

Corresponding Author:sjhong@amc.seoul.kr

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Eom Ji Choi
Asan Medical Center Children's Hospital
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Kun Baek Song
Soonchunhyang University Hospital Cheonan
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Eun Young Baek
Asan Medical Center Children's Hospital
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Min Jee Park
Soonchunhyang University Hospital Bucheon
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Ji-Sun Yoon
Chung-Ang University
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Sungsu Jung
Pusan National University Yangsan Hospital
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Si Hyeon Lee
Asan Institute for Life Sciences
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Mi-Jin Kang
Asan Medical Center
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Hea Young Oh
Asan Medical Center
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So-Yeon Lee
Asan Medical Center Children's Hospital
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Kang Seo Park
Department of Pediatrics Presbyterian Medical Center Jeonju Republic of Korea
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Abstract

ABSTRACT Background Although the development of allergic rhinitis (AR) is associated with multiple genetic and hygienic environmental factors, previous studies have focused mostly on the effect of a single factor on the development of AR. This study aimed to investigate the combined effect of multiple genetic and hygienic environmental risk factors on AR development in school children. Methods We conducted a cross-sectional study, comprising 1,797 children aged 9–12 years. Weighted environmental risk score (ERS) was calculated by using four hygienic environmental factors, including antibiotic use during infancy, cesarean section delivery, breast milk feeding, and having older siblings. Weighted polygenic risk score (PRS) was calculated by using four single nucleotide polymorphisms (SNPs), including interleukin-13 (rs20541), cluster of differentiation 14 (rs2569190), toll-like receptor 4 (rs1927911), and glutathione S-transferase P1 (rs1695). Multivariable logistic regression analysis was used. Results More than three courses of antibiotic use during infancy increased the risk of current AR (adjusted odd ratio [aOR], 2.058; 95% confidence interval [CI]: 1.290–3.284). Having older siblings, especially >2 (aOR, 0.526; 95% Cl: 0.303–0.913) had a protective effect. High ERS (>median; aOR, 2.079; 95% Cl: 1.466–2.947) and PRS (>median; aOR, 1.627; 95% Cl: 1.117–2.370) increased the risk of current AR independently. Furthermore, children who had both high ERS and PRS showed a higher risk of current AR (aOR, 3.176; 95% Cl: 1.787–5.645). Conclusions Exposure to multiple hygienic risk factors during early life increases the risk of AR in genetically susceptible children. Key words: Allergic rhinitis, Hygiene, Genes, Risk factors, Child, Gene-environment interaction, Anti-bacterial agent