Statistical analysis
All statistical analyses were performed using SPSS version 25.0 (IBM
Corp., Armonk, NY, USA). The Pearson’s chi-square test and independentt -test were used to compare the frequency and mean of categorical
and continuous valuables, respectively, between children in current AR
and control groups. Multivariate logistic regression analysis was used
to calculate adjusted OR (aORs) and 95% confidence interval (CI) after
adjusting for age, gender, body mass index (BMI) of children, exposure
to tobacco smoke during early life, parental history of allergic
disease, maternal education, parental income, and area of residence.
The ERS and PRS were divided into two groups, low and high, by median
value, and the low group was used as a reference. Multiplicative
interaction between ERS and PRS on current AR in children was calculated
in the multivariate logistic regression model.