Predictors of non-functional larynx following (chemo)radiotherapy for locally advanced laryngeal cancer

Kristijonas Milinis; Rhydian King; Jeffrey Lancaster@liverpoolft.nhs.uk; Rachel Brooker; Rebecca Zammitt; Mark Wilkie; Jason Fleming; Katharine Davies

doi:10.22541/au.166023183.30764433/v1

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Predictors of non-functional larynx following (chemo)radiotherapy for locally advanced laryngeal cancer

Kristijonas Milinis,
Rhydian King,
Jeffrey Lancaster@liverpoolft.nhs.uk ,
Rachel Brooker,
Rebecca Zammitt,
Mark Wilkie,
Jason Fleming,
Katharine Davies

Abstract

• Non-functional larynx (NFL) was found to affect 30.9 % of patients with locally advanced laryngeal cancer who underwent curative non-surgical laryngeal preservation treatment for stage III/IV disease • The key measures of NFL were long-term gastrostomy and tracheostomy dependence, functional laryngectomy and chronic aspiration. • Multivariate analyses identified current smoking to be associated with 6.8-fold increase in NFL • Patients with pre-treatment hemi-laryngeal fixation were 3.4 times more likely to experience locoregional recurrence.

24 Jul 2022Submitted to Clinical Otolaryngology

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11 Aug 2022Submission Checks Completed

11 Aug 2022Assigned to Editor

02 Oct 2022Reviewer(s) Assigned

19 Oct 2022Review(s) Completed, Editorial Evaluation Pending

19 Nov 2022Editorial Decision: Revise Major

13 Dec 20221st Revision Received

20 Dec 2022Submission Checks Completed

20 Dec 2022Assigned to Editor

21 Dec 2022Reviewer(s) Assigned

05 Apr 2023Review(s) Completed, Editorial Evaluation Pending

21 Apr 2023Editorial Decision: Revise Minor

24 Apr 20232nd Revision Received

26 Apr 2023Submission Checks Completed

26 Apr 2023Assigned to Editor

26 Apr 2023Review(s) Completed, Editorial Evaluation Pending

01 May 2023Editorial Decision: Accept

Abstract

Peer review status:ACCEPTED