Oncologic outcomes
Thirty-one patients (32.9%) developed recurrence: 29 patients had loco-regional recurrence 7 of whom had also distant metastases. Two patient presented with distant metastasis only. Salvage laryngectomy was performed in 9 patients due to recurrence. OS, DFS, DSS at 5 years were 57.6%, 52.1%, 68.4% respectively (Figure 1). A 5-year locoregional control was achieved in 69.1%. Pre-treatment hemi-larynx fixation was found to be associated with a significantly increased risk of locoregional recurrence (hazard ratio (HR) 3.4, CI 1.4-8.4, p=0.007) (Figure 1).