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Validity and reliability of Turkish version of quality-of-life questionnaire in adult patients with common variable immune deficiency
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  • Deniz Eyice,
  • Semra Demir,
  • Halim İşsever,
  • Osman Ozan Yeğit,
  • Ali Can,
  • Özdemir Can Tüzer,
  • Pelin Karadağ,
  • Nida Öztop,
  • Şengül Beyaz,
  • Bahauddin Çolakoğlu,
  • Suna Büyüköztürk,
  • Federica Pulvirenti,
  • Isabella Quinti,
  • Aslı Gelincik
Deniz Eyice
Istanbul University Istanbul Faculty of Medicine
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Semra Demir
Istanbul University Istanbul Faculty of Medicine
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Halim İşsever
Istanbul University Istanbul Faculty of Medicine
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Osman Ozan Yeğit
Istanbul University Istanbul Faculty of Medicine
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Ali Can
Istanbul University Istanbul Faculty of Medicine
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Özdemir Can Tüzer
Istanbul University Istanbul Faculty of Medicine
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Pelin Karadağ
Istanbul University Istanbul Faculty of Medicine
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Nida Öztop
Istanbul University Istanbul Faculty of Medicine
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Şengül Beyaz
Istanbul University Istanbul Faculty of Medicine
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Bahauddin Çolakoğlu
Istanbul University Istanbul Faculty of Medicine
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Suna Büyüköztürk
Istanbul University Istanbul Faculty of Medicine
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Federica Pulvirenti
Umberto I Polyclinic of Rome
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Isabella Quinti
University of Rome La Sapienza
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Aslı Gelincik
Istanbul University Istanbul Faculty of Medicine

Corresponding Author:gelincikasli@hotmail.com

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Abstract

Background and Aims Common variable immunodeficiency (CVID) can affect quality of life (QoL) which can be better assessed with validated scales. Our goal was to validate the Turkish version of the Italian CVID-QoL questionnaire. Methods International recommendations for cultural adaptation and translation process of original scale was followed. CVID patients completed Turkish CVID-QoL questionnaire between October 2019 and January 2020. The Short Form Health Survey (SF-36) was used as a comparative questionnaire. Reliability, reproducibility, factor analysis, content validity, convergent validity and discriminant validity were analysed. Results 50 CVID patients were included in the study. 64 % of patients (n=32), the mean age of the patients was 36.68 ± 13.2 years, the median duration of disease was 52.5 months. The instrument had good internal consistency in 50 patients [Cronbach’s alpha: 0.92, emotional functioning (EF): 0.91, relational functioning (RF): 0.77]. It also revealed high reproducibility in 26 patients QoL global, intraclass correlation coefficient (ICC)= 0.80 (95 % CI 0.56 - 0.91); EF, ICC = 0.78 (95 % CI 0.51- 0.90); RF, ICC = 0.82 (95 % CI 0.59-0.92); Gastrointestinal and skin symptoms (GSS), ICC = 0.89 (95 % CI 0.76-0.95); (p <0.001, p <0.001, p <0.001, p <0.001). QoL global, EF and RF scores showed good convergent validity with similar subscales of SF-36. The number of infections within last 3 months had a significant impact on QoL global, EF and RF (p=0.038, p=0.045, p=0.028). Conclusions The Turkish version of CVID QoL scale has appropriate validity and reliability among Turkish patients with CVID.