We presented an unusual case of iatrogenic esophageal perforation(EP) following trans-esophageal echocardiography(TEE) in a patient with COVID-19.Force applied during the intubation on an inflammatory and fragile wall caused by COVID-19 probably represented the underlying condition that contributed to the EP.Early diagnosis and urgent treatment are essential for a favorable prognosis

The rupture of mitral papillary muscles is a very rare complication of the infective endocarditis. We report a case of anterolateral papillary muscle rupture resulting in severe mitral regurgitation, due to infective endocarditis in a young man without previous heart disease.