Aim of Study: The goal of this study was to evaluate ischemia-modified albumin (IMA) as a novel marker of oxidative stress in tuberculosis patients and to investigate changes occurring in patients. Methods: Our study included 50 patients with active lung tuberculosis and 48 healthy controls. Serum ischemia-modified albumin was measured with automated spectrometric method and results were compared statistically. Results: We found that IMA levels were significantly higher in pulmonary tuberculosis patients than in the control group. Albumin levels were significantly lower in the patient group than in the control group. Conclusion: The results of our study showed that we can use this parameter as a new oxidative stress marker in the pathogenesis of pulmonary tuberculosis. Evaluation of IMA and albumin parameters in patients with pulmonary tuberculosis may contribute significantly to the evaluation of these patients.

Aim of Study: Our aim is to compare dynamic thiol/disulphide homeostasis between patients with acute pulmonary thromboembolism (PTE) and healthy controls. Methods: Our study included 45 patients who were diagnosed with acute PTE and 50 healthy controls. Serum thiol/disulphide was measured. Results: We found that the native thiol, total thiol, native thiol/total thiol levels were significantly lower in the patient group than the control group, while the disulphide, disulphide/natural thiol, disulphide/total thiol levels were significantly higher. Conclusion: We have seen that in patients diagnosed with acute PTE, the oxidant-antioxidant balance shifts towards the oxidative direction. The disulfide/natural thiol ratio can be considered as an oxidative stress parameter in acute PTE. We think that the deterioration in thiol disulfide balance, together with clinical, laboratory and radiological findings, may have diagnostic value in acute PTE patients.

ABSTRACT Aims of Study: To compare dynamic thiol/disulfide homeostasis between patients with with lung tuberculosis and healthy controls. Methods: Our study included 50 patients with active lung tuberculosis and 50 healthy controls. Serum thiol/disulfide was measured with a new automated spectrometric method developed by Erel and Neselioglu, and results were compared statistically. Results: We found that native and total thiol levels were significantly decreased in patients with lung tuberculosis, disulfide/native thiol and disulfide/total thiol levels were found to be higher in lung tuberculosis patients when compared with the control group. However, disulfide levels were higher in the control group than in the patient group. Conclusions: Based on the results of this study, it can be said that oxidative stress is closely associated with lung tuberculosis pathogenesis. There is a need for new studies that will show the possible effects of oxidative stress on lung tuberculosis pathogenesis.