A novel Pinch-based targeting and synthesis procedure in the domain of multiple constraints (e.g. multi-contaminants) for material recycle/reuse networks has been developed in this contribution. The main steps are the identification of the ranking order of material sinks/demands or sources/supplies. This is dependent on the limiting contaminants of sinks. Each contaminant/constraint is assigned a Pinch Diagram (Load vs Flowrate), and the Source and Sink Composite Curves (CC) are plotted for each diagram. The Source CC should be shifted until its lines could form a ‘polygon’ with the Sink CC, for which the points represent the vertices of the polygons. The sequential approach used is to first identify a preliminary resource target and allocated sources for each sink, then to follow certain heuristics for further reduction of the freshwater. The proposed approach provides a minimum resource target and a network design that achieves the targeted fresh resource along with graphical representation.