Although previously confined to regions within Africa, Lumpy Skin Disease Virus (LSDV) infections have caused significantly large outbreaks in several regions of the world in very recent years. In 2019, an outbreak of the disease was reported from India with low rates of morbidity and no reported mortality. However, in 2022, an ongoing outbreak of LSDV spanning over 7 states in India resulted in a reported mortality of over 80,000 cattle over a short period of three months. Here, we report complete genome sequences of 6 viral isolates of LSDV collected from affected cattle during an ongoing outbreak of the disease in Rajasthan, India. Analysis of the viral sequences suggests the genomes from the 2022 outbreak harbour a large number of genetic variations compared to the reference genome and form a distinct lineage. This report also highlights the importance of genome sequencing and surveillance of transboundary infectious agents and genomic characterisation of outbreaks.

Asymptomatic Reactivation of SARS-CoV-2 in a Child with Neuroblastoma Characterised by Whole Genome SequencingSatya Prakash Yadav1, Dhwanee Thakkar1, Rahul C. Bhoyar2, Abhinav Jain2,3, Teena Wadhwa4, Mohamed Imran2,3, Bani Jolly2,3, Mohit Kumar Divakar2,3, Rohit Kapoor1, Neha Rastogi1, Disha Sharma2,3, Paras Sehgal2,3, Gyan Ranjan2,3, Sridhar Sivasubbu2,3, Smita Sarma4,Vinod Scaria2,3Pediatric Hematology Oncology and Bone Marrow Transplant Unit, Cancer Institute, Medanta The Medicity, Gurgaon, Haryana, India.CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi, IndiaAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad- 201002, IndiaDepartment of Microbiology, Medanta The Medicity, Gurgaon, Haryana, India.Correspondence : Dr Satya P Yadav, Pediatric Hematology Oncology & BMT Unit, Cancer Institute, Medanta -The Medicity, Gurgaon, Haryana, India 122001.Email:satya_1026@hotmail.com, Fax: +91 1244962222Total Pages - 4Abstract (word count) – N/ATable - 0Figure - 1Text (word count) – 479Running title –COVID-19 reactivation proven by sequencingKey words – COVID-19; Reactivation; SARS-CoV-2; Genome Sequencing; Neuroblastoma