Extramedullary hematopoiesis (EMH) represents the production of blood cells outside of the bone marrow and occurs in beta thalassemia major. Although EMH usually occurs in the liver, spleen, and lymph nodes, it may also occur in the spinal canal or sacral bone lead to neurological complications

Hematologic malignancies are becoming more prevalent, manifesting in various clinical scenarios. Chronic myelogenous leukemia (CML) is usually diagnosed on routine complete blood count as it is typically asymptomatic. However, it can cause multiple signs and symptoms. We present a patient with appendicitis revealing CML during his workup for abdominal pain.

All people including those with Haemoglobinopathies are at risk of COVID-19 infection. Though those patients were considered vulnerable, a clear prognosis, as well as the possibility of reinfection, was not mentioned before. We report here the first case of Thalassemia beta major who had COVID-19 reinfection detected by screening.