Background: Ewing sarcoma (ES) is a rare malignancy, most commonly presenting as a bone tumor, histologically characterized by sheets of poorly differentiated cells with small, blue, round nuclei and scant cytoplasm. Ewing sarcoma that may originate from bone or soft tissue has an increased tendency to involve the axial skeleton, particularly the pelvis. Case Report: We presented a case of Ewing sarcoma originated from pubis bone, who was underwent percutaneous nephrostomy due to external pressure on the bladder and ureter. Conclusion: We recommend placing optimal drainage, to each obstructed renal unit so treatment can be started as soon as possible