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Ozgur Surmelioglu
Ozgur Surmelioglu

Public Documents 2
Predictive value of ALDH1 and CD44 positivity for radiotherapy response and prognosis...
Ozgur Surmelioglu
Kivilcim Eren Erdogan

Ozgur Surmelioglu

and 5 more

October 26, 2020
Objective: To evaluate of the predictive value of CD44 and ALDH1 expression for prognosis and radiotherapy(RT) response in patients with early-stage laryngeal cancer receiving RT. Materials and Methods: Forty-four patients with early-stage laryngeal cancer were included in the study. Based on retrospective chart review, the patients were divided into those with local recurrence and those without recurrence after RT. Correlation between RT response and pre-treatment immunohistochemical ALDH1 and CD44 staining was evaluated. In addition, survival times were compared between groups. Results: The mean age was found 59.8±9.0 years and 41 were male. There were 20 patients in the non-recurrent group. Immunohistochemical positivity for ALDH1 was found to be significant risk factor for RT failure (p=0.0001), whereas CD44 positivity (p=0.114) were not significant. Disease-free survival was shorter in cases with positive ALDH1 and CD44 staining (p=0.0001). Conclusion: ALDH1 positivity was identified as a significant predictor of DFS and RT sensitivity.
SARCOMAS OF HEAD AND NECK: 31 cases and review of the Literature
Ozgur Surmelioglu
Semra  Paydas

Ozgur Surmelioglu

and 9 more

September 24, 2020
Background: Soft tissue sarcomas are a highly heterogenous group of tumors that are classified by differentiation. Their invasive or destructive growth pattern, recurrence and distant metastatic capacity are variable according to their subtype and also their localization. Aim: The aim of this study is to evaluate clinical characteristics, histopathologic subgroups, therapeutic modalities and clinical course of head and neck sarcomas. Study Design: Retrospective study and review of literature Materials and Methods: Patients with head and neck sarcomas who underwent surgery at XXXX University, Faculty of Medicine, Department of Otorhinolaryngology between 2007 to 2016 were retrospectively evaluated. Demographic features of the patients, histopathologic subtypes, immunohistochemical markers, locations of the tumor, type of surgery, margins of the specimens, type of reconstructive surgery and type of adjuvant treatment were reviewed. Results: The histopathologic subtypes were rhabdomyosarcoma, primitive neuroectodermal tumor, osteosarcoma, chondrosarcoma, leiomyosarcoma, Ewing’s sarcoma and synovyal sarcoma. The most frequent site was nasal cavity and was detected in 7 cases. Local recurrence developed in three patients. Conclusion: Sarcomas of the head and neck region are relatively rare tumors. Radical resection of the tumors is essential for these cases.

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