In recent years, several studies suggested that HBsAg titers in blood samples obtained during Hepatitis B treatment could be used to estimate the treatment outcomes. The present study aims to discuss the correlation between HBsAg quantification levels and the virological, serological and histopathological findings in chronic hepatitis B patients.The study included chronic hepatitis B patients who underwent liver biopsy between 2011 and 2013 at Dicle University, Faculty of Medicine, Infectious Diseases and Clinical Microbiology Clinic.. The patient demographics were recorded (age, gender). Patient AST tests were conducted with the spectrophotometric method. After the DNAs were isolated with AmplipPrep Total Nucleic Acid Isolation Kit, DNA level was determined with the COBAS® Amplip / Cobas® Taqman® HBV test V2.0 for HBV. The patient HBV DNA levels were recorded as IU / ml. HBsAg quantitation was studied with the Access device and the Elisa method.The study was conducted with 53 patients. The mean patient age was 28,73 ± 8.15. Out of the 53 patients, 35 (66%) were male and 18 (34%) were female. The mean patient HBsAg quantitation was 631,42 ± 406.55, fibrosis score was 1,35 ± 0.87, ALT index score was 67,07 ± 53.37, and HAI index score was 4,54 ± 1.55. In the statistical analysis, it was determined that there were negative correlations between the HBsAg DNA level (R: -0,273, P: 0.048) and HBSAG quantitation (R: -0,273, P: 0.048), fibrosis score , ALT (R: -0,477, P: 0.001), and HAI index scores (R: -034, P: 0,013), while there was a positive correlation with the HBeAg positivity (R: 0.477, p: 0.001). There were negative correlations between the HBsAg quantitation level and virological (HBV DNA level), histopathological (fibrosis score, HAI index) findings and a positive correlation with serological (HBeAg positivity) findings. As HBsAg quantitation level increased, fibrosis score and HBV DNA level decreased.

Background: COVID-19, as a contagious infectious disease, can affect many systems and cause changes in inflammatory and hematological parameters. This study aims to research the effects of hematological and inflammatory parameters on prognosis of the disease and the duration of hospitalization. Methods: 186 patients aged 15-92 with positive COVID-19 PCR test results and a control group consisting of 187 healthy individuals with similar characteristics in terms of age and gender are included in the study. Age, gender, hematological variables, and inflammatory parameters of the patients on the 1st and 5th days of hospitalization were recorded retrospectively. Results: The mean age of the patient’s group was 47.0 ± 18.4 years and 54.3% were male. WBC, lymphocyte count, and platelet count were statistically lower in the patient group compared to the control group, while MPV, NLR, and PLR levels were higher. On the 5th day of the patient follow-up compared to admission day, it was observed that the neutrophil count and MPV level were lower; However, the platelet count and ferritin level were statistically higher. While there was a significantly positive correlation between the duration of hospitalization and the 5th day D-dimer (r = 0546, p < 0.001) and ferritin (r = 0.568, p < 0.001); there was a negative correlation between the duration of hospitalization and admission day lymphocyte count (r = 0.256, p = 0.006) and the 5th day lymphocyte count (r = 0.325, p < 0.001). Conclusion: Increased levels of ferritin and D-dimer and decreased count of lymphocyte are among important factors affecting the duration of hospitalization for COVID-19 patients. Furthermore, we think that neutrophil count and MPV levels are low and platelet count and ferritin levels are high during the course of the disease, so these parameters can be used as prognostic indicators of the disease.

Background: The novel coronavirus disease (Covid-19) can progress with mild to moderate or self-limiting clinical findings in children. The aim of this study was to investigate the disease features of Covid-19 in Turkish children. Methods: Children diagnosed by the method of RT-PCR for Covid-19 at the Dicle University Department of Pediatric, between April and June 2020, were evaluated. Hospital records were investigated retrospectively. Results: One hundred and five patients children with the mean age of 108.64±65.61 were enrolled in this study. The most common cause of transmission in pediatric patients was contacting with a family member diagnosed with COVID-19 (n=91, 86.7%).The most common admission complaints were dry cough (n=17, 16.2%), fever (n=16, 15.2%), lassitude and fatigue (n=14, 13.3%) respectively. More than 95 % of all children with Covid-19 had asymptomatic, mild, or moderate cases. CRP was identified only independent factor associated with long duration of hospitalization. Conclusion: The results of this study show preliminary results of a study investigating the effect of Covid-19 on Turkish children. A clear understanding of the local epidemiology of corona virus infections and identification of risk factors is critical for the successful implementation of the prevention and control program.