AUTHOREA
Log in Sign Up Browse Preprints
Essential Site Maintenance: Authorea-powered sites will be updated circa 15:00-17:00 Eastern on Tuesday 5 November.
There should be no interruption to normal services, but please contact us at help@authorea.com in case you face any issues.

Complement mediated hemolysis in a child with COVID-19 infection

Seda Şahin

and 3 more

The novel coronavirus disease 2019 (COVID-19) is a member of Beta coronaviruses that became pandemic by March of 2020. The hematological manifestations related to COVID-19 are mostly lymphopenia, thrombocytopenia, elevated D-dimer, and ferritin levels. Autoimmune hemolytic anemia (AIHA) associated with COVID-19 has been described rarely; however, to our knowledge, complement-mediated autoimmune hemolytic anemia (CM-AIHA) has not been reported in children. Here, we report a child with COVID-19 associated with CM-AIHA.
Diagnostic Value of Lung Ultrasonography in Children with COVID-19

Mina Gharibzadeh Hızal

and 10 more

Background: Lung ultrasound (LUS) has been successfully used in the diagnosis of different pulmonary diseases. Present study design to determine the diagnostic value of LUS in the evaluation of children with COVID-19, and to compare chest X-ray and LUS results with tomography (CT).   Method and objectives: In this prospective multi-center study, 40 children with confirmed COVID-19 were included. LUS was performed to all patients at admission. The chest X‐ray and CT were performed according to the decision of the primary physicians. LUS results were compared with chest X-ray and CT. The sensitivity and specificity and diagnostic performance was determined. Results: Of the 40 children median (range) was 10.5 (0.4-17.8) years. Chest X-ray and LUS were performed on all and chest CT was performed on 28 (70%) patients at the time of diagnosis. Sixteen (40%) patients had no apparent chest CT abnormalities suggestive of COVID-19, whereas 12 (30%) had abnormalities. LUS confirmed the diagnosis of pulmonary involvement in 10 out of 12 patients with positive CT findings. LUS demonstrated normal lung patterns among 15 patients out of 16 who had normal CT features. The sensitivity identified by the chest X-ray and LUS tests was comparedand statistically significantly different (p=0.016). Chest X-ray displayed false-negative results for pulmonary involvement in 75% whereas for LUS it was 16.7%. Conclusions: LUS might be a useful tool in the diagnostic steps of children with COVID-19. A reduction in chest CT assessments may be possible when LUS is used in the initial diagnostic steps for these children.