Abstract
The pandemic condition Coronavirus-disease (COVID-19), caused by the
novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can
take asymptomatic, mild, moderate, and severe courses. COVID-19 affects
primarily the respiratory airways leading to dry cough, fever, myalgia,
headache, fatigue, and diarrhea and can end up in interstitial pneumonia
and severe respiratory failure. Different clinical symptoms caused by
involvement of organs outside the respiratory system have been also
described. Interestingly, reports about the manifestation of various
skin lesions and lesions of the vascular system in some subgroups of
SARS-CoV-2 positive patients as such features outside the respiratory
sphere, are rapidly emerging. However, knowledge about prevalence and
pattern of skin involvement, time of onset, predilection, and its direct
or indirect relation to SARS-CoV-2 is still limited. In order to update
information gained, we provide a systematic overview of the skin lesions
described in COVID-19 patients, discuss potential causative factors and
describe differential diagnostic evaluations.