3.3 Severe cutaneous adverse drug reaction
There are COVID-19 positive cases with DRESS (drug reaction with eosinophilia and systemic symptoms) described (unpublished reports), which is a severe cutaneous drug reaction with non-specific histologic findings (Figure 9A and B). The diagnosis is based on a combination of clinical symptoms and laboratory parameters including frequently occurring hepatic abnormalities, eosinophilia and exanthema with facial swelling and lymphadenopathy (73 ). The culprit drug should be stopped immediately upon identification. In some cases, eosinophilia could hardly be controlled with corticosteroids, which led to the successful use of agents interfering with the IL-5 axis (unpublished reports).