Conclusion
Recent observation of involvement of the skin and the vasculature in
subgroups of SARS-CoV-2 infected patients illustrates the need for a
precise stratification and differential diagnostic evaluation of those
patients in order to gain more insight into mechanisms of this novel
virus. So far, pathophysiologic mechanisms behind the skin lesions
occurring in the context of COVID-19 are speculative, could be related
to the virus, drugs and other co-factors. Knowledge from other viral
infections and drug induced lesions of the skin and vascular system
might be transferred and observations on SARS-CoV-2 patients
systematically evaluated to rapidly increase our knowledge on this
issue. For mild cases of COVID-19, skin lesions can be a diagnostic
hint; for severe cases, due to multiorganic involvement and
interdisciplinary approach is of outmost importance.