Comorbidities
Skin lesions might at least in part or completely result from the reactivation or aggravation of pre-existing skin diseases such as urticaria, autoimmune disease or other diseases with SARS-CoV-2 and soluble mediators and immune mechanisms induced both in the organs involved and systemically in the blood (25 ). Comorbidity rate increases the rate of mortality of COVID-19 with cardiovascular diseases, hypertension, diabetes mellitus and obesity being major risk factors (26 ). Sine adipocytes express ACE2 and might serve as a reservoir for SARS-CoV-2, this fact might explain in part the higher risk of obese patients (17 ).