Introduction: Cystic Fibrosis (CF) is a genetic disease with progressive lung disease, malnutrition, liver disease and CF-related diabetes (1). Viral infections are a major factor causing pulmonary exacerbations in CF (2). COVID-19 has caused a worldwide pandemic with high death rates. As science suggests, patients with CF would be severely affected with a high rate of morbidity, hospitalization and mortality. In a recent study published by Cosgriff et al. (3) people with CF who were 15 years and older, infected with COVID-19 appear to have better outcomes than initially anticipated. We report the only two cases of CF in literature less than 15 years of age with better than expected outcomes post COVID-19 infection and discuss the possible effects of hypertonic Saline as a plausible explanation.

Cystic fibrosis (CF) is a disease with chronic lung disease that is exacerbated by viral infection. COVID-19 has caused a worldwide pandemic with high death rates. As science suggests, patients with CF would be severely affected with a high rate of morbidity, hospitalization and mortality. Our aim was to present two cases with CF in highly prevalent COVID-19 regions of the world.