Objective: To study the pregnancy outcomes of vaginal delivery and neonatal prognosis during the epidemic of COVID-19, and to summarize the management of vaginal delivery. Design: Retrospective review of medical records Setting: Zhongnan Hospital of Wuhan University, Wuhan, China Sample: Pregnant women (n=63) with vaginal delivery from January 20 to March 02, 2020 Methods: Retrospectively analyzed the outcomes of vaginal delivery in 10 pregnant women with clinical diagnosis of COVID-19 and 53 pregnant women without COVID-19 from January 20 to March 02, 2020. The related laboratory tests, imaging tests and the SARS-CoV-2 nucleic acid tests results were also analyzed in neonates delivered by pregnant woman with clinical diagnosis of COVID-19. Main Outcome Measures: Delivery outcomes and neonatal outcomes Results: (1) There were no significant differences in gestational weeks, postpartum hemorrhage (245±49.72ml vs 237±85.99ml), and perineal resection rates (10% vs 7.55%) between the two groups. (2) There were no significant differences in birth weight of neonates(3283±449g vs 3274±456g) and neonatal asphyxia between the two groups. Results of the blood routine, throat swabs test for nucleic acid of SARS-CoV-2 and chest radiograph of neonates delivered by pregnant woman with clinical diagnosis of COVID-19 showed no signs of the SARS-CoV-2 infection. Conclusions: Pregnant women with mild COVID-19 can delivery vaginally without exacerbation of COVID-19 and without increasing the risk of SARS-CoV-2 infection in the neonates. Keywords: COVID-19；outcomes of vaginal delivery；neonatal prognosis；management Tweetable abstract：Pregnant women with mild COVID-19 can try vaginal delivery