Amid the ongoing COVID-19 pandemic and Mpox outbreak, the Sudan Ebolavirus (SUDV) had arisen as a new menace in Uganda. Multiple human epidemics in Africa have been traced back to four genetically distinct strains: Sudan ebolavirus, Zaire ebolavirus, Bundibugyo virus, and Taï Forest virus. While African fruit bats are thought to be a reservoir host for the ebola virus, scientists throughout the world are looking for confirmatory evidences that bats play a significant role in the spread of the disease.

Emerging pathogens have been an eternal threat to mankind. In a series of pandemics caused by notorious coronaviruses, a newly emerged virus is creating panic among world population. Originating in late December, 2019 from Wuhan, China, the SARS-CoV-2 is spreading its terror throughout the world. The virus is rapidly transmitted due to unavailability of effective theranostics. In this study, multiple sequence alignment of SARS-CoV-2 spike protein was done and four novel inserts were found in comparison to SARS-CoV. Using computational informatics tool viz. IEDB B-cell epitopes prediction tool, B-cell immunogenic epitopes of SARS-CoV-2 spike protein was predicted. Five novel potent epitopes i.e. ‘71SGTNGTKRFDN81, 247SYLTPG252, 634RVYST638, 675QTQTNSPRRARSV687 and 1054QSAPH1058 were selected as antigenic determinants and their docking with the 3D structure of ACE2 receptor was delineated. The quantum of information generated by this study will prove beneficial for development of effective therapeutics, diagnostics and multiepitopic vaccines to combat this ongoing menace.