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David Wright
David Wright
PDRA at UCL, London
I am a molecular modeller and research software engineer. My research revolves around the use of computational techniques to understand proteins and how their composition and structure impact treatment efficacy. I have particular interest in how sequence changes produce drug resistance in HIV and cancer, and alter the solution structure of antibodies. A key part of my work is the development of tools to automate and analyse molecular dynamics simulations deployed on high performance computing and cloud resources.
London

Public Documents 1
Up-Goer Five challenge: Patient specific protein-drug binding affinity calculations
David Wright

David Wright

November 02, 2017
Sick people need making-better-stuffs to get well. We use computers to work out which making-better-stuffs should work best for different people. All people have slightly different small inside body things. Doctors want making-better-stuffs to stick to the right inside body things as well as possible to fix the problems that make people sick. In our computers we make pretend small inside body things just like those in different people and move them around like like they do really. We use them to find out which make-better-things stick the best without giving many making-better-stuffs to people which is slow and sometimes makes other things go wrong. We can also use our pretend small inside body things to help people put together new, better, making-better-stuffs.\cite{Wright_2014,Bhati_2016}

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