Assam, Northeast India, is a part of the Indo-Burma biodiversity hotspot. This rich floristic repository provides an abundant resource for ethnomedicinal practices among indigenous Assamese communities and frequently utilizes locally available medicinal plants for the treatment of various disorders. This study focuses on documenting the traditionally used plant-based formulations used by local practitioners in Assam, Northeast India, for the treatment of liver diseases. We searched various databases, such as PubMed, Web of Science, and Google Scholar, to find ethnomedicinal surveys conducted in Assam. The search was performed using different terms, including ethnomedicinal survey, folk medicine, and indigenous knowledge. A total of 151 medicinal plant species belonging to 62 families were identified as being employed in the management of liver disorders. Leaves are the most commonly utilized plant part because of their accessibility and ease of harvesting. Among families, Asteraceae and Fabaceae are most dominant in local hepatoprotective practices. Folk medicine is the result of decades of accumulated knowledge and practices by people who live in rural communities, based on their needs, and provides an important source of information to assist the search for new pharmaceuticals, which are safe, effective, and inexpensive. These findings emphasize the importance of traditional ethnomedicinal knowledge in managing liver diseases and highlight species with strong therapeutic potential. Further pharmacological and phytochemical validation is required to confirm their efficacy. This study also underscores the socioeconomic relevance of preserving indigenous medicinal practices and supports the integration of validated traditional remedies into broader healthcare frameworks.