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Yulan Shi
Yulan Shi

Public Documents 1
The Plant Hippo Pathway: An Evolved Hub for Strategic Resource Allocation Governing G...
Yulan Shi
Li-Zhe An

Yulan Shi

and 2 more

December 27, 2025
For sessile plants, survival hinges on the dynamic allocation of limited resources among growth, defense, and reproduction. We propose that the plant Hippo signaling network has evolved into a central strategic hub governing these fundamental trade-offs. Building upon its evolutionarily conserved pleiotropic roles, this hub in plants has acquired unique regulatory capacities. It integrates hormonal, developmental, and stress signals to act as a cellular decision-maker, moving beyond the paradigm of a linear growth regulator. Plant-specific innovations—including a direct SIK1-MOB1 interaction that bypasses the canonical SAV1 scaffold, dual-specificity NDR kinases, and MOB1A/B heterodimer formation—underpin this adaptive evolution. Crucially, the antagonism between SIK1 and MOB1 fine-tunes the jasmonate pathway, functioning as a molecular “rheostat” for the growth-defense balance. Viewing the plant Hippo pathway through the lens of “adaptive trade-off management” not only redefines its biological significance but also charts a new research agenda. We outline priorities to quantify signal flux through the hub, resolve the structure of plant-specific complexes, and manipulate this decision-making system to engineer crops with optimized resilience and yield.

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