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Ji-Feng Bai
Ji-Feng Bai

Public Documents 1
Sc(OTf)3 catalyzed reaction of bicyclobutanes [1.1.0] with isatin to prepare cyclobut...
Ji-Feng Bai
Mostafa Sayed

Ji-Feng Bai

and 4 more

December 18, 2025
Herein, we report the synthesis of functionalized of bicyclo[1.1.0]butanes (BCBs) enabled by Sc(OTf) 3 catalyst through ring-opening of 1,3-disubstituted bicyclic butane and carbonyl compounds. Interestingly, substituted indoline-2,3-diones were found to be suitable substrates to react with bicyclobutanes under mild reaction conditions, where functionalized cyclobutene products with two consecutive centers successfully obtained in good to high yields (up to 82%).

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