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Drift drives foraminiferal community assembly on a carbonate platform
Tao Li
Bo Li

Tao Li

and 4 more

November 05, 2024
Community composition is determined largely by drift, selection, dispersal, and speciation. The crucial issue is disentangling the relative importance of different processes in community assembly. However, this issue has not been adequately discussed in benthic foraminiferal communities. Here, we studied the community composition, co-occurrence network, and community assembly of benthic foraminifera (protozoa) on the Xisha carbonate platform and their coupled relationships. The community composition was determined via the environmental DNA (eDNA) technique. Heavy metals, grain sizes, loss on ignition (LOI), organic carbon, and pH were measured for environmental assessment. The results showed that spatial variations in foraminiferal community composition were mainly controlled by organic carbon, whereas the effects of other variables were minimal. Similarly, spatial variations in the co-occurrence network were determined by organic carbon and pH. Despite the impacts of environmental variables on community composition, null and neutral models demonstrated that foraminiferal community assembly is driven by ecological drift instead of selection. This study is the first to couple community composition and co-occurrence networks with community assembly processes. A hypothesis was proposed that selection increases community heterogeneity and network heterogeneity, whereas stochastic processes eliminate such heterogeneities. This mechanism would bridge the gap between processes and community patterns. A comparison with our previous study revealed that foraminiferal community assembly may depend on specific systems (habitats). This insight could inform new strategies for the conservation of marine biodiversity.
Transcriptomics reveal molecular signatures of a resolved sexual conflict and respect...
Miguel Baltazar-Soares
Melanie  Heckwolf

Miguel Baltazar-Soares

and 6 more

November 05, 2024
Genome sharing in gonochorous species is expected to result in intraspecific conflicts due to intersexual competition. The emergence of sexual dimorphism is thus connected to the evolution of mechanisms that, starting from a similar genomic background, produce sufficiently disparate phenotypes to attenuate sexually antagonistic selection. From a molecular perspective it can be briefly summarised by sex-specific differences in gene expression, splicing, non-coding regulation or epigenetic marks. The tawny owl (Strix aluco) is a reverse sexually dimorphic species where females and males evolved distinct body sizes (smaller males), which results in sex-specific roles and therefore are a robust example of resolved sexual conflict. Here we explore, transcriptional variation among 27 juvenile tawny owls with the objective of investigating molecular signatures of resolved sexual conflict. Tawny owls also exhibit melanin-based colour polymorphism, which, given the body size differences between sexes, suggest a sex-specific onset of pigmentation. Our results show substantial sex-specific variation in terms of differentially expressed genes, single nucleotide polymorphisms and alternative exon usage in genes involved in life history traits (ZGRF1, VLDLR), behaviour (GSK3B, SLC12A) and aspects of growth (GHR, EGF, EPS8L2). Exploring sex-specific DEG revealed enrichment for biological functions associated with melanogenesis and pigment granulation in males, which together with the identification of a single up-regulated gene involved in melanogenesis (RAB38) in brown males strongly suggests different timings for the onset of pigmentation between sexes. Overall, our results reveal some of the sex-specific molecular signatures expected to be observed in the context of a resolved sexual conflict.
Mitigating Climate Change Without Exacerbating Climate Injustice
Peter B Reich

Peter B Reich

and 3 more

November 05, 2024
Mitigating climate change and social injustice are critical, interwoven challenges. The result of elevated greenhouse gas emissions, climate change is driven by grossly unequal emissions among individuals, socioeconomic groups, and nations. Yet its deleterious impacts disproportionately affect poor and less powerful nations, and the poor and the less powerful within each nation. This climate injustice prompts a call for mitigation strategies that buffer the poorest and the most vulnerable against climate change impacts. Unfortunately, all emissions mitigation strategies also reshape social, economic, political, and ecological processes in ways that may create climate change mitigation injusticesi.e., a unique set of injustices not caused by climate change, but by the strategies designed to stem it. Failing to stop climate change is not an answerthis will swamp all adverse impacts of even unjust mitigation in terms of the scope and scale of disastrous consequences. However, mitigation without justice will create uniquely negative consequences for the more vulnerable. The ensuing analysis systematically assesses how climate change mitigation strategies can generate or ameliorate injustices. We first examine how climate science and social justice interact within and among countries.
Popfinder: A highly effective artificial neural network package for genetic populatio...
Katie Birchard
Chris Boccia

Katie Birchard

and 4 more

November 05, 2024
The ability to assign biological samples to source populations based on genetic variation with high accuracy and precision is important for numerous applications from ecological studies through wildlife conservation to epidemiology. However, population assignment when genetic differentiation is low is challenging, and methods to address this problem are lacking. The application of artificial neural networks to population assignment using genomic data is highly promising. Here we present popfinder: a new, easy to use Python-based artificial neural network pipeline for genetic population assignment. We tested popfinder both with simulated genetic data from populations connected by varying levels of gene flow, and with reduced-representation sequence data for three species of seabirds with weak to no population genetic structure. Popfinder was able to assign individuals to their source populations with high accuracy, precision and recall in most cases, including both simulated and empirical datasets, except in the weakest empirical population structure dataset, where the comparator programs also performed poorly. Compared to other available software, popfinder was slower on the simulated data sets due to hyperparameter tuning and the fact that it does not reduce the dimensionality of the data set; however, all programs ran in seconds on empirical data sets. Additionally, popfinder provides a perturbation ranking method to help develop optimized SNP panels for genetic population assignment, and is designed to be user-friendly. Finally, we caution users of all assignment programs to watch both for leakage of data during model training, and for unequal detection probabilities.
Comments on ”Systematic Review and Meta-Analysis of Comparative Studies: Transcathete...
Imane El Amri

Imane El Amri

November 05, 2024
Comments on ”Systematic Review and Meta-Analysis of Comparative Studies: Transcatheter Versus Surgical Closure for Postinfarct Ventricular Septal Defect”Imane El AmriDepartment of Medicine and Surgery, Wenzhou Medical University, Wenzhou, Chinaamrimane20@gmail.comDear Editor,I am impressed by the meta-analysis conducted by Yamaguchi et al. which compares transcatheter with surgical closure of postinfarct ventricular septal defect (PIVSD). This is a promising investigation of the key role of minimally invasive interventions against conventional surgery, which is the topic of the investigation. The authors could not find any short-term mortality differences, but they noticed a higher residual shunt/reintervention rate in the transcatheter group. Contrary to that, their analysis also uncovers significant draws that need to be examined further.Dependence on non-randomized, observational studies is a limiting factor of this internal validity. Notably, although the short-term mortality findings are encouraging, they fall short of the strength of evidence typically associated with randomized controlled trials (RCTs). The 7.8% crossover rate could have risked the results, as the selection bias might have run the comparative efficacy benignly[1] . Either a randomized trial or a propensity-matched study might have resulted in a more dependable evaluation.Another issue is the significant variation in patient features, particularly PIVSD size. The smaller defect sizes in the transcatheter group may confound mortality and complication rates. Research shows that smaller defects lead to an improved outcome with transcatheter closures [2], making it important to consider defect size as a criteria for treatment option. Using stratified analyses to address this heterogeneity may improve the data’ interpretability.Yamaguchi et al. suggest that surgical closure is the primary choice for patients who are eligible. This recommendation is consistent with other research that states that residual shunt rates are lower in surgical operations [3]. However, bearing in mind the advantages that transcatheter closure may have for those who are high-risk, like decreased invasiveness and faster recovery, a closer examination into the stratification criteria of patients is a priority.[1] A. Yamaguchi, J. Shimamura, S. Fukuhara, H. Ueyama, H. Takagi, and T. Kuno, ‘Systematic Review and Meta‐Analysis of Comparative Studies: Transcatheter Versus Surgical Closure for Postinfarct Ventricular Septal Defect: Transcatheter Versus Surgical Closure for PIVSD’, J. Card. Surg., vol. 2024, no. 1, p. 8159580, Jan. 2024, doi: 10.1155/2024/8159580.[2] S. Shrivastava, S. Shrivastava, S. V. V. Allu, and P. Schmidt, ‘Transcatheter Closure of Atrial Septal Defect: A Review of Currently Used Devices’, Cureus, Jun. 2023, doi: 10.7759/cureus.40132.[3] F. VandeWerf, ‘Management of acute myocardial infarction in patients presenting with ST-segment elevation’, Eur. Heart J., vol. 24, no. 1, pp. 28–66, Jan. 2003, doi: 10.1016/S0195-668X(02)00618-8.
Investigating Biotechnological Advances and Reproductive Biology in Donkeys: A Prospe...
Muhammad Faheem Akhtar
Muhammad Umar

Muhammad Faheem Akhtar

and 5 more

November 05, 2024
Donkeys have held significant cultural and practical roles across diverse societies and nations for centuries. In the contemporary context, they serve various purposes, including recreational activities, therapeutic interventions, and, notably, the breeding of mules. While donkeys and horses share some reproductive similarities, they also exhibit distinct differences. Jennies, the female donkeys, have a more extended reproductive cycle and gestation period compared to mares, with unique reproductive behaviors. Unlike horses, donkeys show less seasonality in their reproductive patterns, with factors beyond photoperiod influencing their reproductive cycles. Furthermore, the reproductive organs of male donkeys, known as jacks, are larger than those of stallions, and they require more time to achieve ejaculation. In terms of assisted reproduction, artificial insemination with fresh semen is a common practice on many farms, and certain efficient protocols using cooled semen have been implemented. However, the use of frozen-thawed semen remains a challenging aspect. While there have been advancements in embryo transfer techniques for donkeys in recent years, achieving higher pregnancy rates is essential for it to become a more effective reproductive method. Therefore, a more profound understanding of donkey reproductive physiology is necessary to develop optimal protocols for the application of reproductive biotechnologies in this species.
Co-registered eye-movements and brain potentials reveal multiple effects of context a...
Allyson Copeland
Brennan Payne

Allyson Copeland

and 1 more

November 05, 2024
This study investigates how expectancy and plausibility influence behavioral and neural measures of language processing during naturalistic reading comprehension. Prior event-related potential (ERP) studies show evidence of distinct post-N400 positivities to violations of semantic expectancy and plausibility using artificial serial presentation but have yet to establish these phenomena during naturalistic reading. Therefore, we recorded simultaneous eye-movements and EEG while participants read highly-constraining sentences with expected, unexpected (but plausible), and anomalous target words. Time-locked to the pre-target word, we observed a contextually-graded parafoveal N400 effect. The N400 was facilitated (i.e., reduced) when the word was subsequently fixated, suggesting trans-saccadic integration of semantic features. At target fixation, we also observed a late anteriorly-distributed positivity to unexpected target words and a posteriorly-distributed positivity to anomalous target words, effects that were not present when time-locked to the pre-target word. Eye tracking measures show that readers were sensitive to both expectancy and plausibility at target fixation. In conclusion, we show that readers can begin accessing semantic information in parafoveal vision, but higher-level semantic processing may require the orchestration of both parafoveal and foveal representations.
Factors Affecting Utilization of Health Care Services among Nasahblood and Ayah 4 Int...
Ayan Hussein Korse
Vitalis Okoth

Ayan Hussein Korse

and 4 more

November 05, 2024
Background: In 2021, about 4.5 billion people were not fully covered by essential health services. About 2 billion people face financial hardship, including 1 billion experiencing catastrophic out-of-pocket health spending globally. Objectives: to identify factors affecting utilization of Health care services among IDPs. Design: Cross-sectional study design. Site: Nasahblood and Ayah 4 Internally Displaced Persons. Participants: 271 households. Main Measures: The study used ordinal logistic regression analysis. Then, the data were exported to the STATA window for data analysis. Descriptive Analysis and ordinal logistic regression were used. Results. The research uncovered diverse patterns in healthcare service usage: 14.36% (n=26) displayed high usage, 12.16% (n=22) exhibited moderate usage, and 73.48% (n=133) showed low usage. For internally displaced individuals residing in Nasahablood and Ayah 4 regions of Hargeisa, Somaliland, accessibility substantially affected healthcare service utilization (P< 0.027, Coef = -1.403584). Similarly, affordability was found to have a significant adverse impact on healthcare service use within the same population (P>0.000, Coef=-2.272459). Moreover, socioeconomic factors, particularly gender, negatively influenced healthcare service utilization among the internally displaced persons in these areas (P< 0.026, Coef =1.77102). Conclusion. The research highlights the need for targeted interventions to improve healthcare access and affordability for displaced populations, ultimately aiming to enhance their overall health outcomes and well-being
Vacuolated parabasal cells in Papanicolaou smears are cellular changes caused by huma...
Shuichi Mizuno
Kaori Okayama

Shuichi Mizuno

and 9 more

November 05, 2024
In cervical cancer screening, cytology is used as a triage test to refer high-risk human papillomavirus (HR-HPV)-positive women for colposcopy, but its accuracy is inadequate. The present study aimed to demonstrate that the presence of atypical cells with large vacuoles in the cytoplasm of parabasal cells, referred to as vacuolated parabasal cells (VPCs), observed in the Pap smears of HPV-positive women is associated with specific HPV genotypes. Among 2175 patients, 310 with a single HR-HPV infection and cytological diagnosis of high-grade squamous intraepithelial lesions (HSIL) or atypical squamous cells not excluding HSIL (ASC-H) were included, of which 86 were infected with HPV16. Biopsy results revealed that 69 (80.2%) patients had cervical intraepithelial neoplasia Grade 2 or higher (CIN2+). VPCs were found in 47 (54.7%) of HPV16-infected cases, indicating a significant increase of VPCs in HPV16-infected cases ( p < 0.01). Episomal HPV16 load was quantified in 142 VPCs and 156 HSIL (ASC-H) cells using LBC samples from five patients, with a median of 987 copies in VPCs, significantly higher than those in HSIL (ASC-H) cells (176 copies; p < 0.001). VPCs in Pap specimens were identified not only as cells altered by HPV16 infection but also as CIN2+-derived cells and HPV16-producing cells.
Reproductive interference alters species coexistence in nematodes due to asymmetric s...
Rebecca Schalkowski
Katja Kasimatis

Rebecca Schalkowski

and 3 more

July 16, 2024
Species coexistence is shaped by a range of biotic and abiotic factors. Beyond predation, parasitism, and competition, one species may interfere with another's reproduction to induce sexual exclusion from a habitat. Here, we test for reproductive interference from inter-species mating between sympatric nematodes Caenorhabditis macrosperma and C. nouraguensis. Higher intrinsic population growth of C. nouraguensis arises from greater reproductive output by both sexes, predicting it to be superior in resource competition. Mate discrimination between species is incomplete, however, with inter-species mating errors reducing lifespan and reproductive fitness of female C. nouraguensis only. These asymmetric costs arise within hours, due to ectopic migration of C. macrosperma's giant sperm cells. We modelled the population dynamic impacts of reproductive interference, then confirmed rapid sexual exclusion in mixed-species communities with multi-generation experiments. These findings demonstrate the profound ecological implications of reproductive interference for demographic parameters and species coexistence through a cell-mediated mechanism of inter-species harm.
Reservoir host community and vector density predict human tick-borne diseases across...
Paulo Mateus Martins
Michael Mahon

Paulo Mateus Martins

and 2 more

November 05, 2024
Tick-borne disease (TBD) incidences are rising globally, highlighting the need for effective prevention strategies that consider the ecological context of disease transmission. We analyzed the relationship between human prevalence of four TBDs in the eastern U.S. and various ecological and climatic factors. Babesiosis showed a negative relationship with mean annual temperature, while ehrlichiosis exhibited no significant associations. Anaplasmosis prevalence was positively linked to nymphal tick densities, with competent host abundance mediating the relationship between prevalence and small mammal richness. Lyme disease prevalence correlated positively with densities of ticks, infected ticks, deer, and reservoir hosts, while negatively correlating with precipitation, temperature, and small mammal richness. We expand on the dilution effect in Lyme disease by linking reservoir hosts, tick density, and human cases at broader scales. Our findings suggest that TBD intervention efficacy may vary based on tick and host dynamics, underscoring the importance of ecological context in designing effective strategies.
Early Celiac Plexus Block in Metastatic Pancreatic Cancer: A Case Report
Brian Fardman
Christina Sheedy

Brian Fardman

and 2 more

November 05, 2024
IntroductionThe celiac plexus is a visceral nerve bundle located behind the pancreas. It overlies the anterolateral surface of the aorta and innervates many visceral organs, including the pancreas. The plexus has been established as a targeted area for therapy in pancreatic cancer1. Celiac Plexus Block (CPB) is a minimally invasive procedure that has been shown to reduce pain and improve quality of life in patients. The implementation of Early versus Delayed CPB has also been studied; use of an Early CPB has been shown to decrease overall narcotic consumption and reduce adverse effects due to analgesic use when compared to Delayed CPB2. Early CPB is defined as an intervention initiated promptly once a patient meets the criteria, with abdominal pain being the most common indicator3,4. Delayed CPB takes a wait-and-see approach and is only implemented when the patient develops persistent refractory pain or has intolerable adverse effects from analgesics4. This article presents a case in which early CPB was performed in a 73-year-old female that had pancreatic adenocarcinoma with lung metastases. The patient presented to CentraState Medical Center (CSMC) and underwent the procedure prior to onset of recalcitrant abdominal pain and need for a long course of analgesics. Early interventional treatment has been shown to be extremely beneficial in cancer patients5. This case report adds to the current belief that intervention with CPB should be early in patients with pancreatic cancer and will benefit them more than a wait-and-see approach by decreasing adverse effects from analgesics, improving patient comfort, and allowing for better patient care.
The Impact of Verapamil on Fluconazole-Induced Torsades de Pointes
Hayder M.  Al-kuraishy
Ali Algareeb

Hayder M. Al-kuraishy

and 6 more

November 05, 2024
Fluconazole (FZL) is a widely used antifungal medication that may cause serious adverse effects, particularly acute liver injury, convulsions, and QT prolongation, which can lead to ventricular arrhythmias like Torsades de Pointes (TdP). FZL is contraindicated in pregnancy due to risks of abortion and birth defects. To mitigate the risk of TdP associated with FZL, it is advisable to avoid combining it with other QT-prolonging medications. The calcium-channel blocker verapamil has been identified as a potential therapeutic agent for managing TdP, while also influencing the pharmacokinetics and pharmacodynamics of FZL. Not only does verapamil demonstrate antifungal activity against certain species, but it also enhances the antifungal efficacy of FZL and significantly reduces the occurrence of TdP. Clinical case studies suggest that verapamil can effectively suppress TdP developments in patients at risk, thereby indicating that the combination of verapamil and FZL may offer dual benefits of increased antifungal efficacy and reduced adverse cardiac effects.
Upper appendicular, pelvic and axial skeletal pathology with poor performance
Troy  Trumble

Troy Trumble

November 05, 2024
TitleUpper appendicular, pelvic and axial skeletal pathology with poor performance
Distributed Task Scheduling and Edge Collaboration for Network Reliability Improvemen...
Jie Liu
Zian Cai

Jie Liu

and 3 more

November 05, 2024
Summary: Low Earth orbit (LEO) satellites has been foreseen as a promising paradigm to enable reliable connectivity in the Internet of Things (IoT) enabled smart grids. Considering the limited coverage of the traditional base station (BS), in this paper, we put the edge computing servers on the LEO satellites to realize ubiquitous service coverage and wireless transmission in the power grid environment. However, the inherent high mobility of LEO satellites poses challenges in maintaining stable communication links and efficiently managing the heterogeneous network resources among a myriad of IoT devices, including those in smart grids. To address these challenges, in this paper, we propose a collaborative MEC framework leveraging the collaboration computing among LEO satellites. In the framework, we consider the dynamic nature of LEO satellite net-works and formulate an optimization problem to maximize Quality of Experience (QoE) of IoT users. Then, we adopt the Proximal Policy Optimization (PPO) algorithm to tackle this dynamic problem. Simulation results demonstrate that the proposed solution not only improves the overall performance of LEO-enabled IoT networks by reducing the latency and energy consumption of users but also significantly enhances the efficiency of heterogeneous network management.
Risk trade-offs in a heterogeneous landscape: red deer vary their fine-scale behaviou...
Suzanne van Beeck Calkoen
Niko Balkenhol

Suzanne van Beeck Calkoen

and 9 more

November 05, 2024
Behavioural changes of prey towards large carnivores can have profound impacts on prey populations and the ecosystems they inhabit. However, European studies have thus far only found limited support for prey behavioural changes to returning large carnivores. We examined the trade-off between forage quality and perceived predation risk of an ambush (Eurasian lynx; Lynx lynx) and cursorial predator (wolf; Canis lupus) on the behavioural response of red deer (Cervus elaphus) in an experimental set-up within semi-natural grasslands and forest patches. We hypothesized that red deer would i) reduce visitation frequency and duration but increase their time spent vigilant in the presence of olfactory cues of large carnivores, ii) show a stronger response towards the scent of wolf with increasing distance from the forest edge in open areas and a stronger response towards lynx in forested areas independent of distance, and iii) show a stronger response in areas with lower forage quality. We tested these using camera trap video data on 76 plots at different distances within the forest and open areas (mown and unmown) in the Grafenwöhr military training area, Germany. Within three trials, we applied each of the following scent treatments to each plot: wolf urine-scat, lynx urine-scat, and horse urine-dung. To analyse forage quality, we determined crude protein concentration from the herbaceous vegetation by near-infrared spectroscopy. Red deer avoided open areas further away from the forest edge when wolf scent was present, whereas an increase in vigilance was found in forested areas towards lynx scent. In contrast to plots with horse and lynx scent, red deer visitation frequency on plots with wolf scent remained low despite increasing crude protein concentration. Our research is the first to experimentally show that large carnivores with different hunting mode induce different changes in the foraging behaviour of free-ranging red deer.
The circadian clock regulates innate immunity and cardiovascular diseases
dan qiu
Lixia Li

dan qiu

and 4 more

November 05, 2024
Circadian rhythms are 24-hour oscillating variations in physiology and behavior generated by the circadian clock. The circadian clock tightly regulates multiple aspects of the innate immune system, including immune cells and multiple immune parameters. Fluctuation of innate immune cells and their effector molecules often dictate the magnitude of the inflammatory responses. Many innate immune cells gather at the lesion sites during cardiovascular diseases. Their escalating recruitment and effector function typically drive the pathologic process, often coinciding with cardiovascular events during their peak activities. Recognizing the influence of the circadian clock on the trafficking and function of innate immune cells is imperative, as it profoundly impacts immune and inflammatory responses to specific cardiovascular ailments like atherosclerosis and myocardial infarction. The proposal of innate immunotherapy targeting the circadian clock holds promise for providing valuable insights into strategies to prevent and manage cardiovascular diseases.
Acute Lung Injury is Attenuated by Sodium Formononetin-3’-sulfonate via Fas/PDK1/STAT...
Yunying Lv
Guanghua Zhang

Yunying Lv

and 3 more

November 05, 2024
Formonetin is an isoflavone derived from Astragalus membranaceus (Fisch.) Bunge, of which a sulfonate version, sodium formonetin-3’-sulfonate (ND308), and has been shown to improve water solubility when administering injections. However, the therapeutic effects elicited by ND308 toward acute lung injury (ALI) remain unclear. In our study, we examined the in vivo effects of ND308 in a lipopolysaccharide (LPS)-induced two-hit rat ALI model. Then, to investigate the anti-ALI mechanisms mediated by ND308, LPS-induced injury in human pulmonary microvascular endothelial cells (HMs) was examined in vitro. Continuous ND308 administration (20 mg/kg for 3 days) via the tail vein elicited protective effects in our rat model via changes in overall pulmonary function Hounsfield units, and gross pulmonary pathological indicator the lung coefficient and lung microscopic pathology scores, respectively. Furthermore, tight junction (TJ) protein expression values for claudin 18.1 changed from 0.42 to 0.91, while FAS, p-PDK1, p-STAT3, and PDK1 distribution in nuclei changed from 2.54 to 1.29, 2.26 to 1.07, 2.67 to 1.19, and 2.31 to 1.14, respectively. In in vitro studies, LPS-induced HMs showed similar results; lower FAS, p-PDK1, p-STAT3, and PDK1 distribution in nuclei and higher claudin 18.1 values. When combined, ND308 appeared to alleviate ALI by strengthening claudin 18.1 expression via FAS/PDK1/STAT3 inhibition.
Dual Switching Mode Scheme for Hybrid Boost-Flyback/ Flyback Photovoltaic Microinvert...
Feng Zhang
Peng Li

Feng Zhang

and 5 more

November 05, 2024
Due to a significantly increase of switching frequency in F mode of boundary conduction mode (BCM) hybrid boost-flyback/flyback (BF/F) microinverter, simply applying discontinuous conduction mode (DCM) to F mode could be an intuitive method to solve this issue but brings a serious distortion in the fixed operation mode transition point, which would deteriorate the power quality. Hence, based on a transition mechanism of variable transition point and a small modification of the topology, this paper proposed a novel dual switching mode scheme, BCM-BF/DCM-F, in which the microinverter is in BCM when operated at BF mode, while in DCM when F mode. This new scheme smoothly limits the switching frequency of DCM-F mode to a specified value, thereby minimizing the switching losses and guaranteeing a satisfactory power quality. Furthermore, it maintains the natural soft-switching features of BCM-BF mode: the zero-voltage switching (ZVS), the zero-current switching (ZCS), as well as the intrinsic snubber. To reduce the cost and signal to noise ratio, a ON-time control strategy without high-frequency sensors is employed in this scheme. The characteristics of the proposed BCM-BF/DCM-F scheme, including primary side peak current, switching frequency, and voltage stress, are also analyzed and discussed in detail. Finally, numerous experimental results are presented to verify the theoretical analyses and the performance of the proposed dual switching mode.
Semantic Calibration of Contextual Embedding in Large Language Model Generative Pathw...
Diana Anahaeva

Diana Anahaeva

and 4 more

November 05, 2024
Language models have achieved substantial advancements in generating text that approximates human-like coherence, yet challenges in maintaining contextual alignment across diverse inputs remain unresolved. Addressing these challenges through a novel mechanism, contextual-distillation introduces a structured recalibration of embeddings to mitigate issues of semantic drift and inconsistency in generative pathways. This study presents a thorough investigation into contextualdistillation's capacity to enhance embedding coherence and generative accuracy, deploying a comprehensive methodology centered on embedding recalibration across multi-layer attention structures. The experiments, conducted on a recent open-source model, reveal that contextual-distillation significantly reduces entropy in attention distributions, aligns embeddings with intended semantic cues, and improves coherence metrics across complex input types. Quantitative results demonstrate that the proposed mechanism enables refined pathway calibration, strengthening the model's resilience to context shifts and syntactic variations over extended sequences. Implications of this study highlight the potential for contextual-distillation to serve as an adaptable framework within language model architectures, thereby advancing the technical robustness required for high-fidelity natural language applications.
On the Convexity and Smoothness in Lp Spaces: New Explorations
Yuchen Wang

Yuchen Wang

November 05, 2024
This paper delves deeply into the convexity and smoothness characteristics of L p spaces. Through rigorous mathematical derivations, it comprehensively expounds on the convexity determination methods under different situations, including the proof of uniform convexity and the analysis of special cases when p=1 and p= ∞ . Meanwhile, it reveals the relationship between convexity and integrability. For smoothness, the Gateaux differentiability and Frechet differentiability are studied in detail, and the intrinsic relationship between convexity and smoothness is thoroughly explored. These research results are helpful for deepening the understanding of the geometric structure of L p spaces and are of great significance to the theory of functional analysis and its related application fields.
Inferring plant acclimation and improving model generalizability with differentiable...
Doaa Aboelyazeed
chonggang xu

Doaa Aboelyazeed

and 5 more

November 07, 2024
Net photosynthesis (AN) is a major component of the global carbon cycle, with significant feedback to decadal-scale climate change. Although plant acclimation to environmental changes can modify AN, traditional vegetation models in Earth System Models (ESMs) often rely on plant functional type (PFT)-specific parameter calibrations or simplified acclimation assumptions, both of which lacked generalizability across time, space and PFTs. In this study, we propose a differentiable photosynthesis model to learn the environmental dependencies of Vc,max25, as this genre of hybrid physics-informed machine learning can seamlessly train neural networks and process-based equations together. Compared to PFT-specific parameterization of Vc,max25, learning the environment dependencies of key photosynthetic parameters improves model spatiotemporal generalizability. Applying environmental acclimation to Vc,max25 led to substantial variation in global mean AN, calling for the attention to acclimation in ESMs. The model effectively captured multivariate observations (Vcmax25, stomatal conductance gs, and AN) simultaneously and, in fact, multivariate constraints further improved model generalization across space and PFTs. It also learned sensible acclimation relationships of Vc,max25 to different environmental conditions. The model explained more than 54%, 57% and 62% of the variance of AN, gs, and Vcmax25, respectively, presenting a first global-scale spatial test benchmark of AN and gs. These results highlight the potential of differentiable modeling to enhanced process-based modules in ESMs and effectively leverage information from large, multivariate datasets.
Fasciitis Ossificans of the Groin: a Case Report and Literature Review
Hamdi Al Shenawi
Suhair Al Saad

Hamdi Al Shenawi

and 10 more

November 05, 2024
Fasciitis Ossificans of the Groin: a Case Report and Literature ReviewHamdi Al Shenawi1, Suhair Al Saad1, Rami Yaghan1, Khalid Al-Sindi2, Lulwa Alsadah1, Zainab Salmeen1, Noor Al Rumaihi1, Shamil Naji2, Shazia Qaiser3, Rabbani M. Daoud4, and Noor Al Shenawi1.Department of Surgery, College of Medicine and Medical Sciences, Arabian Gulf University, BahrainDepartment of Radiology, Ibn Al Nafes Hospital, Manama, BahrainMedical Simulation Center, College of Medicine and Medical Sciences, Arabian Gulf University, BahrainDepartment of Research and Statistics, University of York, York, United Kingdom
Design and research of business processor of electricity consumption information coll...
Cheng Xingliang
Zhou Mingli

Cheng Xingliang

and 5 more

November 05, 2024
In order to improve the electricity consumption information collection system, this research designed a new type of business processor, which can realize the information collection of the user’s electricity collection environment, and realize the collection of different information on the surrounding environment to detect the data information of the surrounding environment. Through the marketing and utilization of smart IoT, it realizes the operation of electricity data collection, parameter issuance, electricity statistics and line loss calculation for residential users, special transformer users, and substation gateways, which improves the intelligence and automation capabilities of electricity information collection. When designing the front-end processor, the power consumption information collection function is improved by establishing a connection with the front-end processor. The research also designed an active queue management (Active Queue Management, AQM) algorithm model , which can improve the power consumption information data transmission and application capabilities. Through experiments, the method of this research has greatly improved the business capability of the electricity consumption information collection system with high accuracy.
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