To investigate the relationship between disaster exposure and posttraumatic growth, as well as the mediating role of cognitive emotion regulation and the moderating role of dark personality traits, a study was conducted among 1,508 individuals who experienced severe flooding in Henan Province on 20 July 2021. The participants completed measures including the Disaster Exposure Scale, the Posttraumatic Growth Scale, the Cognitive Emotion Regulation Scale and the Dark Triad Scale. Results showed that (1) disaster exposure had a significant negative predictive effect on posttraumatic growth; (2) adaptive cognitive emotion regulation and maladaptive cognitive emotion regulation fully mediated the relationship between disaster exposure and posttraumatic growth; (3) the front path, direct path, and back path of the mediating effect of dark personality traits were involved in the relationship between maladaptive cognitive emotion regulation and posttraumatic growth. The practical implications of this study suggest that targeted assistance can be provided through psychological interventions and self-management training to enhance posttraumatic growth, alleviate the negative impact of disaster exposure, and promote psychosocial well-being.

The equations of motion for a spin magnetic dipole in nuclear magnetic resonance imaging (MRI) and a qubit’s Bloch-sphere state vector in quantum computing (QC) share the same mathematical form. Semi-classical solutions in both fields show strong behavioral similarities: in MRI, the elevation and azimuthal angles describe the physical orientation of the spin, while in QC, they are purely mathematical parameters—yet both follow the same equations.This paper introduces qubit behavior, excitation, and readout from an electrical engineering perspective, requiring little or no prior knowledge of quantum theory. It also highlights how decades of MRI expertise in spin control can inform qubit manipulation in quantum gates, especially when gate times approach coherence limits. Under such conditions, additional control pulses may be needed to refocus dephasing while maintaining the desired unitary operation—a challenge directly analogous to the inhomogeneous-dephasing refocusing routinely performed in MRI.

There have been lots of debates about the concept of entanglement since Einstein’s famous statement “spooky action at a distance”. This contribution firstly reviews the main stages of the acceptance history of the concept of quantum entanglement. It then presents a comparison between the quantum and the physical coupling of two entangled quantum resonators, where the term “physical” is used in its classically intuitive sense. It is shown that both conform to Einstein’s Relativity Theory and do allow for neither instantaneous nor superluminal transmission of information. The physical model relies on connecting the two quantum resonators via a waveguide operating below the cutoff frequency of its dominant mode. Apparent superluminality might take place within the isolated lossless system. Coupling the system to its surroundings for conducting a measurement or observation breaks such apparent superluminality and makes the system conform to the Relativity constraints. A comprehensive transient analysis of the physical model might be needed to understand its role in the entanglement and how it interacts with the quantum one.It is, however, worth mentioning that although the analysis presented in this paper is valid for resonant circuits. It cannot be applied to entangled moving particles like electrons and photons because of the lack of physical coupling in these cases.

Objective: Vulval cancer account for 5% of gynaecological malignancies worldwide with 1400 new cases diagnosed in the UK every year. VIN is a premalignant condition that requires appropriate identification and treatment to prevent progression to vulval cancer. The standard treatment for VIN/vulval cancer is surgical and can result in considerable morbidity, therefore alternative treatments have been sought. Plasmajet ® is a surgical energy device that utilises neutral argon plasma to ablate tissue. This UK-based study includes the largest cohort of patients to date with VIN who have undergone Plasmajet ® treatment and attempts to lay a foundation for understanding the impact of this novel treatment. Design: Single centre retrospective observational study over ten-year study period. Setting: Gynaecological Cancer Centre, London, England. Population: All women with VIN 1-3 treated with Plasmajet® between September 2014 and March 2024 inclusive. Methods: Data on demographics, background, treatment, complications, and outcome, was collected from electronic medical records and analysed using Microsoft Excel. Main Outcome Measures: Treatment, complications, and outcome. Results: Forty-six patients were included; the majority had high-grade VIN; 18 patients (39%) had VIN 3, 12 patients (26%) had VIN 2/3 and five patients (11%) had VIN 2. 127 Plasmajet ® treatments were administered; seven patients (15%) had disease progression, 21 (46%) remain under active surveillance without evidence of progression, 12 (26%) have been discharged with the remaining lost to follow-up. Complication rates were 7%. Conclusions: This study has shown the potential efficacy and safety profile of Plasmajet ® in the largest cohort of patients with VIN to date.

Objective: To standardize obstetric simulation training curriculum on the main obstetrical emergencies in the Italian National Program for residents. Recruitment: experts all around the Country with proven experience in teaching Gynecology and Obstetrics, simulation activities and proven clinical experience in the management in labor complications and peripartum emergencies, participated at the study (SIMOBE Group). Setting: Specific Objective Structured Assessment of Technical Skills checklists were created or modified, and finally approved. Methods: Delphi study was conducted in 4 different rounds to reach a shared checklist for each emergencies Main outcome: Development of OSATS checklist for the major obstetric emergencies Results: A consensus on specific OSATS checklist has been reached in all the obstetrical emergencies. The level of appreciation for each OSATS has been considered good or excellent in most of the cases: shoulder systocia (around 82%), external cephalic version (around 94%), vacuum application (around 75%), management of abnormal CTG in labor (around 42%), post-partum hemorrhage (around 96%), reverse breech extraction (around 72%), Maternal collapse (around 94%), forceps vaginal application (around 76%), non-cephalic second twin delivery assistance (around 96%), assisted breech delivery (around 94%), third-fourth degree perineal laceration repair (around 82%) Conclusion: Development of OSATS checklists on the main obstetric emergencies is pivotal to provide standardized competencies to the personnel dedicated to childbirth.. The SIMOBE working group, recommends the use of these OSATS throughout the national territory.

Francesco Cerini1*, Gianpasquale Chiatante1, Andrea Chiocchio1, Valeria Mazza1, Gianluca Piovesan1, Alessandro Chiarucci2, Marco Musiani2, Marco Milazzo3,4, Luigi Maiorano5, Carlo Rondinini5, Daniele Canestrelli1

Saccadic eye movement as initial presentation of Gaucher’s disease in childrens- a case report of diagnostic difficultyRamesh Khadayat1, Sucharita Tuladhar1,Sri ram KC1, Bijesh Shresth1, Sailesh Shrestha1, Ramesh Basnet1, Shreya Thapa1, Dipendra Magrati11. Patan Academy of Health Sciences, Lagankhal, LalitpurCorrespondence :-Ramesh KhadayatEmail:- rameshkhadayat123@gmail.com

A document by Omar Haidar . Click on the document to view its contents.

MANAGEMENT OF TYPE -1 PLASTIC BRONCHITIS - A pediatric CASE REPORT AND a brief REVIEW

Plants are constantly exposed to various abiotic stresses, such as drought, salinity, and extreme temperatures, significantly impacting their growth, development, and productivity. To cope with these challenges, plants have evolved intricate signaling pathways mediated by phytohormones, including abscisic acid (ABA), jasmonic acid (JA), and brassinosteroids (BR). These hormones regulate stress responses by activating specific transcription factors, protein kinases, antioxidant systems, and other downstream effectors. This review highlights the molecular mechanisms underlying these pathways, emphasizing the interplay between phytohormones and their roles in modulating stress tolerance. By integrating recent findings, this paper provides insights into the potential biotechnological applications for enhancing plant resilience to environmental stresses.

Planetary exploration is rapidly gaining importance within the space research community. Autonomous locomotion of rovers requires consideration of several mobility aspects to ensure safety, including avoiding hazardous areas that can cause the robot to become immobilized in soft soil or damaged in sharp terrains. Furthermore, when executing autonomous guidance, selecting an appropriate path to follow is crucial to reduce energy consumption and improve the overall distance traveled by the rover. This directly impacts the rover’s performance and the possible scientific outcome of the mission. This paper addresses the optimization of the autonomous locomotion of Mars rovers by acting on the guidance and control layers. Firstly, an enhanced velocity-based traction controller is proposed, permitting omnidirectional motion while simultaneously addressing slip and kinematic incompatibilities. The controller acts directly at the wheel command level to further improve traction and tracking performances, reducing position and heading errors. The performance metrics evaluated within the traction controller are then used to dynamically update the cost map of the environment. Finally, a higher-level path planner is integrated considering kino-dynamic constraints, continuously providing new paths according to the map updates. The proposed framework has been validated through simulation and real-world experiments on the MaRTA rover of ESA’s Planetary Robotics Laboratory. The results demonstrated that the proposed controller achieves better traction and tracking performance, further improved by the dynamic cost map updates.

A document by Sara Gomez. Click on the document to view its contents.

1 IntroductionThyroid-associated ophthalmopathy (TAO) is an immune-mediated inflammatory disorder that affects the orbital tissues, commonly associated with Graves’ disease. The condition is characterized by symptoms such as eyelid retraction, exophthalmos, diplopia due to extraocular muscle involvement, and in severe cases, optic nerve compression leading to vision loss1. Treatment modalities for TAO include systemic corticosteroids, orbital radiotherapy and orbital decompression surgery2,3.Choroidal folds are a clinical sign observed as undulations in the retina and choroid, typically presented with blurred vision or metamorphopsia4. These folds can result from various conditions that cause sufficient compressive stress within the choroid, such as choroidal and orbital tumors and scleral buckling procedures4. Patients with TAO who exhibit choriordal folds often experience severe and chronic compression. However, this finding can also be observed during acute and severe exacerbations5,6. Treatment approaches for choroidal folds are primarily directed at the underlying cause, which may involve immunosuppressive therapy or surgical intervention7.The authors report a case of a 54-year-old male presenting with a one-year history of bilateral vision loss and choroidal folds, who was diagnosed with TAO previously. Subsequent examinations revealed bilateral cataracts and lens dislocation. Computed Tomography scan showed mild bilateral extraocular muscle thickening without orbital apex crowding. So the patient was advised to undergo cataract surgery at first, and his vision was restored. Two months following the procedure, the patient again exhibited blurred vision, along with severe restriction of eye movements in all directions in the right eye. Further assessment confirmed the diagnosis of dysthyroid optic neuropathy (DON), and the patient was subsequently treated with tocilizumab.

Untreated Choroidal Melanoma With Obvious ExudationXintong Lin, BA 1,2; Jiang Qian, MD1,2; Kang Xue, MD1,2#1 Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China2 Key Laboratory of Myopia of the State Health Ministry, and Key Laboratory of Visual Impairment and Restoration of Shanghai, China

The prominent feature of autonomous vehicles is collecting real-time data in the form of road images, video through on-board sensors and cameras. Such data is then deployed to optimize the vehicular traffic network. This paper proposes a novel framework for traffic data optimization and network slicing in 6G. The main idea is automatically get the training sample from the global model. Higher sample learning accuracy is improved by deploying knowledge distillation-based training mechanism. The traffic visual data privacy is preserved using adaptive differential method. Experimentations are performed using vehicle and other datasets. Simulations results show that the proposed method has superior performance as compared with existing methods.

Urachal Mucinous Cystic Tumor of Low Malignant Potential in a 43-Year-Old Man: Case Report and Literature ReviewSali Alatasi1*, Khaled Murshed 1, Ibrahim A. Khalil 2, Issam Al Bozom11. Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar2. Department of Urology, Hamad Medical Corporation, Doha, Qatar*Correspondence:Dr. Sali Alatasi , E-mail: Salatasi@hamad.qa

IMDSP-BSoS is a novel System-of-Systems (SoS) framework integrating Blockchain, Federated Learning, ListenFirst ML (LFML), wearable devices, and edge-cloud computing to address secure, efficient, and scalable healthcare data management. The framework employs Adaptive Privacy Sharding (APS) for advanced privacy and supports context-aware decision-making, enabling robust distributed operations. Formulated as an optimization problem, IMDSP-BSoS balances predictive performance, data security, latency, and scalability. It achieves strong results, including AUC of 0.9569 and 88% accuracy on the HCC dataset, AUC of 0.9378 and 85% accuracy for CKD, and 94% accuracy for wearable sensor-based anomaly detection. With an 80ms latency, it ensures real-time responsiveness, while stable blockchain throughput highlights scalability and robustness. Leveraging Docker and Kubernetes, the system dynamically scales under high workloads. Compared to traditional models, IMDSP-BSoS excels in security, adaptability, and efficiency, providing a transformative solution for modern healthcare data management.

The Qinling-Daba Mountains (QDM), extending east-west in central China, span warm temperate and subtropical zones and are characterized by complex geographical transitions and high biodiversity. They actually also act as a significant ecological corridor between the Tibetan Plateau and East China plains, but this almost has not been addressed. This study uses plant species data of 40 national nature reserves within QDM and 18 in adjacent area, performs consensus clustering at the levels of species, genus, and areal-type, traces the origins and dispersal routes of 89 Chinese endemic genera, and, finally, assesses the importance and areal differentiation of environmental factors on species distribution. The results show:①The QDM as a corridor contribute greatly to the high biodiversity in the study areas, particularly in the easternmost and westernmost sections,②The QDM promote species interactions and exchanges between west China and east China. Central-East China components (41 genera) and North China components (8 genera) spread southwestward; Southwest components (24 genera) spread eastward and northeastward; while Northwest components (6 genera) show limited eastward spread. ③Multi-year average precipitation, elevation, and coldest quarter temperature significantly influence plant distribution.④Elevation differences (peak, base, and average) under 1000m among reserves enhance plant dispersal, resulting in obvious corridor effect. This study provides theoretical support for understanding the corridor effect in the study area and its contribution to biodiversity pattern of China.

Overgrazing and low temperature prevent plants sexual reproduction, and belowground bud banks play an important role in perennial plant communities. The purpose of the study is to explore the bud bank characteristics of alpine meadow with elevation changes. We studied the bud bank distribution, size and composition of alpine meadow at 3450 to 3950 m elevation using a unit soil excavation method on the eastern Zoige Plateau. Our results showed that the bud density at the low elevation was higher than that at the high elevation as a whole. The bud bank comprise tiller, long and short rhizome buds. Bud bank composition varied with elevation, tiller buds were the dominant ones, accounted for 35.47% to 65.28% of total buds. The tiller bud density was significant correlated with the elevation, and the proportion of tiller bud and short rhizome bud significant correlated with the elevation. Buds were mostly concentrated in 0-10 cm sod layer, accounted for 93.41% to 100% of total buds, and there were fewer buds distributed in 10-30 cm sod layer. The aboveground biomass of plants increased gradually with increasing elevation, and the belowground biomass decreased gradually as a whole. The aboveground biomass was extremely significant correlated with the tiller buds density. Redundancy analysis (RDA) showed that sod layer properties affected bud bank composition. Total phosphorus, total nitrogen, available phosphorus content was the most important factor explaining and contributing to the variation of bud density. Studies have shown that plants in alpine meadows maintain a certain size of bud banks, which ensures the renewal and recovery of the plant community in the later stages. The distribution and composition of plant bud banks vary with increasing elevation, plants constantly alter the bud bank and adjust propagation strategy to cope with environmental changes and maintain the community stability.

Background: At present, a consistent and standardized method for evaluating the effectiveness and safety of anticoagulant treatment in such patients remains lacking. Objective: The purpose of this research was to assess the efficacy and safety of anticoagulant treatment for patients with sepsis. Methods: A comprehensive search was carried out on PubMed, Embase and Cochrane Library to identify Randomized Controlled Trials (RCTs) which compared the efficacy and safety of anticoagulants with placebo or no treatment in patients with sepsis. The reduction in 28/30-day all-cause mortality or the regression of disseminated intravascular coagulation (DIC) was regarded as effective, while bleeding complications constituted the most prevalent adverse events. Results: A sum of 19 RCTs encompassing 8,177 patients were incorporated. In all sepsis patients, the anticoagulant group exhibited an 8% decrease in the death risk when contrasted with the placebo group. The combined relative risk [RR] was 0.92 (with a 95% confidence interval [CI] of 0.86 - 0.98; P = 0.02). Anticoagulant therapy might potentially reduce patient mortality (RR 0.87, 95% CI 0.62 - 1.22, P = 0.42) and enhance the regression rate of DIC (RR 1.62, 95% CI 1.32 - 2, P < 0.00001) in 6 studies with a baseline of DIC. Nevertheless, the employment of anticoagulants augmented the bleeding risk in patients (RR 1.31, 95% CI 1.16 - 1.49, P < 0.0001). Conclusion: The research discovered that anticoagulant treatment lessened the mortality rate among patients with sepsis and enhanced the regression of DIC in those patients with sepsis - associated DIC.

Introduction: Caregiver burden is well characterized in adults with psychosis but less is known about the burden experienced by carers of children with psychosis. In this secondary analysis, we examined burden reported by caregivers of children with clinical high risk for psychosis and psychotic disorders to test an explanatory model for caregiver burden. Methods: Cross-sectional analyses examined burden experienced by caregivers of children with clinical high risk for psychosis and psychosis who were recruited from an outpatient psychiatric clinic. Caregiver burden was assessed with the Zarit Burden Inventory. Structural equation modelling was employed to examine a model assessing the simultaneous effects of factors related to burden among caregivers of children at clinical high risk for psychosis and diagnosed with psychotic disorders. Results: The study involved 85 caregivers of children aged 6-17. The latent variable for positive caregiving attributes, which included parenting confidence and communication, had a direct effect on caregiver burden, with greater levels of positive caregiving attributes associated with decreased burden. Direct effects of social support and the latent variable for primary/secondary stressors on burden were not observed. There was a significant indirect effect for social support through positive caregiving attributes to mitigate the effects of primary/secondary stressors on caregiver burden. Conclusion: The results provide preliminary evidence supporting the importance of social support, parenting confidence, and caregiver-child communication as key targets for intervention. Moreover, our findings suggest that despite stressors, such as suicidal behaviour and psychiatric hospitalisations, modifiable factors exist to serve as protective buffers against caregiver burden.

Cardiopulmonary resuscitation (CPR) is a life-sustaining technique for cardiac arrest that is not without its own risks. Myocardial puncture from traumatic CPR is a rare but serious potential complication of CPR that can lead to significant morbidity and mortality. Our case demonstrates posterior left ventricular wall perforation from a rib fracture during CPR and highlights the importance of post-CPR echocardiography in the assessment of CPR-associated cardiac injuries that may warrant intervention.

In this paper, a simple and novel residual parameter extraction technique is provided for impedance substrate calibration standards. It uses the measured scattering parameters of four calibration standards, i.e., the THRU, SHORT, OPEN, and LOAD standards, with only the DC resistance known in advance. Based on the electric structures and the frequency range of interest, the equivalent circuit of each standard is provided. The residual parameters in the equivalent circuits might show frequency dependence or frequency non-dependence, which are both considered in the following analysis. In the parameter extraction algorithm, no other calibration is needed. Instead, only the recorded raw data of the four standards are used, by assuming that the two ports of the SHORT, OPEN, and LOAD standards are symmetric and identical. A series of validation experiments are performed on a commercial calibration substrate, within the broad frequency range from 200 MHz to 110 GHz . The results have shown that the extracted residual parameters by using the proposed method are in very good consistency with the values provided by the manufacturer. In addition, the extracted parameters are further used for SOLT calibration, by measuring another group of calibration standards on the commercial calibration substrate. The calibration accuracy and reliability are further verified by using another open structure, a transmission line, and mismatched load.

Objective: Interleukin-6 (IL-6) is a crucial cytokine for treating rheumatoid arthritis (RA). Prognostic nutritional index (PNI) is a nutritional indicator originally developed for predicting prognosis after cancer surgery. This potentially has an association with IL-6 activity. We retrospectively assessed the relationship between PNI and disease activity index regarding IL-6 using unicentral retrospective cohort data. Methods: RA outpatients were chosen after examining the relationship between IL-6 signatures and PNI. In RA patients, correlations between PNI and 28-joints disease activity score using C-reactive protein (DAS28) were evaluated with methotrexate (MTX) administered or not (Phase 1), biologic or synthetic-targeted disease-modifying anti-rheumatic drugs (b/tsDMARDs) administered (Phase 2 or later). Studies were performed at initiation (baseline; BL) and every three months after. Results: After confirming a substantial correlation with IL-6 signatures, PNI showed a significant correlation with DAS28. Especially in Phase 1, when MTX was prescribed, and in Phase 2, when an IL-6 inhibitor, Janus Kinase (JAK) inhibitor, and tumor necrotizing factor (TNF) inhibitor with MTX prescription was administered, PNI at BL showed a significant correlation with the movement of DAS28 after that in IL-6 inhibitor administrated patients. Conclusions: PNI is associated with IL-6 activity and can predict DAS28 response after MTX and IL-6 inhibitors.