Acupuncture treatment for the management of common peroneal nerve injury: a case reportKCMIn a pediatric case of common peroneal nerve injury, acupuncture treatment led to nearly complete functional recovery, restoring muscle strength and sensory function after pharmacological interventions failed. The acupuncture may promote nerve regeneration and improve neurogenic muscle atrophy, which could serve as an effective alternative treatment option.KeywordsAcupuncture; common peroneal nerve; nerve; electroacupunctureIntroductionCharacterized by its slender and fragile nature, the common peroneal nerve exhibits limited resistance to tension and compression. It ranks as the second most frequently involved nerve in cases of peripheral nerve mononeuropathy, following the radial nerve, with an incidence of 50.9%[1-2]. Due to its relatively large descending nerve bundle, superficial and fixed position, and the predominant surrounding bony structures, it is susceptible to compression and subsequent injury under poor postures or pathological conditions[3]. Conditions associated with common peroneal nerve injury include trauma, compression, tumors, neuritis, and iatrogenic injuries. Post-injury, patients may experience abnormal sensations such as pain and numbness on the anterolateral aspect of the calf and the dorsal surface of the foot, leading to foot drop and a varus deformity. These symptoms typically manifest in a characteristic steppage gait. Damage to the common peroneal nerve not only significantly hinders sensory and motor functions but also severely impacts the patient’s daily living abilities, profoundly diminishing their quality of life and adversely affecting their mental health.Peripheral nerves exhibit a complex structure, and the probability of regenerating nerve fibers re-establishing functional connections with their original target organs after injury is relatively low, making recovery challenging. Treatment options for peroneal nerve injury depend on the type and severity of the injury and may include various surgical methods, as well as pharmacological treatments such as neuroprotective agents, anti-inflammatory drugs, neurotrophic factors, and stem cell therapies. Surgical treatments are intricate with poor functional recovery outcomes post-operation[3]. Pharmacotherapy is limited in its effects, with the prolonged medication frequently required, yet the outcomes are often minimal[4].Clinical studies show that acupuncture is beneficial in some peripheral neuropathies[5-6] and can treat the common peroneal nerve injury, with the characteristics of convenience, small wound, good prognosis and short treatment cycle[7-9]. The common peroneal nerve and the radial nerve may recover faster than other peripheral nerve[10].The case report discusses a 5-year-old child with common peroneal nerve injury, who showed no significant improvement in symptoms after taking neurotrophic medication. Subsequently, acupuncture treatment was chosen, and after two months of continuous therapy, the child basically recovered normal motor function. The innovative aspect of this case lies in the fact that acupuncture treatment for common peroneal nerve injury in preschool-aged children has not been previously reported.Case History/examinationThe patient, a 4-year-old male, presented with left foot drop for one month and was seen in the department of acupuncture and moxibustion, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing on November 24, 2023.The patient’s parents reported that one month ago, the patient began experiencing impaired mobility in the left lower limb and left foot drop due to prolonged sleeping in a position that compressed the calf. The patient sought medical attention at Beijing Jishuitan Hospital, where relevant examinations ruled out tumors and other potential causes. Ultrasound examination revealed slight thickening of the left common peroneal nerve compared to the contralateral side. Electromyography indicated severe damage to the left common peroneal nerve. As shown in the figure1 and 2. No significant improvement was observed after two weeks of continuous mecobalamin administration.Physical examination revealed impaired movement below the left knee joint, with left toes pointing downwards and inverting, exhibiting a steppage gait while walking. There was diminished pain and temperature sensation on the lateral side of the left calf and dorsal foot. Atrophy of the anterior tibial muscle on the left was noted, with dorsal flexion muscle strength of the foot graded as I and plantar flexion as IV. Inversion and eversion muscle strength were graded as V-. Dorsiflexion of the ankle joint was 0°, and plantar flexion was 15°. No other abnormalities were observed during the physical examination.The patient did not report any other symptoms, and his overall condition was good.Differential diagnosis, investigations and treatmentThe common peroneal nerve injury can be diagnosed by the ultrasound examination and electromyography.The patient received acupuncture treatment every other day for a consecutive period of 2 months. The scheme included needling at the following points on the left side: Yinlingquan (SP9), Yanglingquan (GB34), Zusanli (ST36), Sanyinjiao (SP6), , Xuanzhong (GB39), Kunlun (BL60), and JieXi (ST41). Moxibustion was applied to Zusanli (ST36) and retained for 20 minutes. As shown in the figure3.With the increase of patients’ acceptance of acupuncture and moxibustion, electrical stimulation was applied to Yanglingquan (GB34) and Zusanli (ST36) starting from the second week using a Huatuo brand electroacupuncture apparatus (SDZ-IIB) with the following parameters: continuous wave, 1Hz frequency, intensity of 3, retained for 20 minutes.All needles (diameter 0.30 mm, length 40 mm) were inserted at a 90-degree angle to a depth of 15-20 mm and retained for 20 minutes.Conclusion and ResultsThe calf circumference 5 cm below the patellar apex was measured, with the circumference of the left calf being 20.5 cm prior to treatment. After one month of continuous treatment, the patient began to regain pain and temperature sensation at the site of the lesion, with the left calf circumference increasing to 22 cm. The follow-up ultrasound examination still indicates that the left common peroneal nerve above the fibular head is slightly thicker compared to the contralateral side, and a comprehensive diagnosis in combination with clinical findings is recommended, as shown in the figure4. By the final treatment session, the patient regained pain and temperature sensation at the site of the lesion, with no obvious drooping or inversion of the left foot. Muscle strength of dorsiflexion, plantar flexion, inversion, and eversion of the left foot had returned to Grade V. The left ankle joint showed 20° of dorsiflexion and 45° of plantar flexion. The patient no longer exhibited a steppage gait, wirh walking, running, and jumping performed smoothly and freely, as shown in the figure5 and 6. Due to the significant pain caused by the electromyography examination, a follow-up electromyography was not performed on the child for humanitarian reasons. The patient’s family refused to repeat B ultrasound review. The patient’s family was advised to alter sleeping positions of the child and to continue monitoring the recovery. The patient reported no other treatments sought during the acupuncture therapy period. At a 3-month follow-up, there was no recurrence of the injury to the peroneal nerve, and the patient was able to resume normal activities.DiscussionIn this case, the patient did not show significant improvement after taking neuroprotective medication. and the ultrasonic examination report showed no obvious nerve compression or displacement. Considering the patient’s the age was younger, the his family refused surgery, so they tried to seek acupuncture treatment. The patient received acupuncture treatment every other day for a consecutive period of 2 months. By the final treatment session, the patient regained pain and temperature sensation at the site of the lesion, and muscle strength in dorsiflexion, plantarflexion, inversion, and eversion of the left foot had recovered to grade V, with normal daily activities.Peripheral neuropathic diseases can be treated clinically by stimulating nerve roots or nerve trunks[11]. In this case report, the selected acupuncture points primarily reside along the common peroneal nerve. Acupuncture at local acupoints effectively stimulates the damaged nerve, such as ST36, which is located at the anterior tibial muscle with the deep peroneal nerve lying deeper; GB34 is situated at a branch of the common peroneal nerve, and current studies have shown that acupuncture at GB34 can effectively prevent further atrophy of skeletal muscle[12]; GB39 is positioned over the extensor hallucis longus and tendon; ST41 has the superficial peroneal nerve superficially and the deep peroneal nerve deeper[13]. By needling muscles, tendons, and ligaments directly reaching the affected area, this technique utilizes the excitation of nerve fibers to induce action potentials,accordingly to activate muscle fibers, alleviating muscle atrophy and restoring motor and sensory functions of the limbs[14].After the first-week treatment, due to increased patient acceptance of acupuncture, electroacupuncture was introduced during the remaining session. Electroacupuncture, a common adjunctive therapy in acupuncture, involves the application of a microcurrent similar to the body’s own bioelectricity to the needles after insertion. It is widely used in the treatment of neurologic injuries, showing significant effectiveness. Low-frequency electrical stimulation can delay skeletal muscle atrophy and promote muscle regeneration, effectively restoring lower limb motor functions[15-16]. Extensive clinical practice has demonstrated that electroacupuncture significantly enhances the motor and sensory functions of damaged peripheral nerves and is a safe and effective treatment method[7]. Research has shown that electroacupuncture not only promotes the function and proliferation of Schwann cells, regulates local blood flow, and reduces local inflammatory responses to support nerve regeneration, but it also inhibits apoptosis of injured neuronal cells and protects surviving neurons. In target organs, electroacupuncture stimulation can increase glycogen content in skeletal muscles, reduce lactate levels, inhibit muscle cell apoptosis, and delay atrophy in muscles lacking nerve supply. Early intervention using low-frequency currents is found to be particularly beneficial[17].One limitation of this case report is the absence of records regarding the assessment of lower limb motor function using a standardized scale. Additionally, there was no follow-up electromyography (EMG) or ultrasonic examination conducted after the completion of acupuncture treatment to evaluate the extent of nerve recovery.Common peroneal nerve injury is a frequently encountered peripheral nerve injury. Surgical intervention is effective for this condition, but it is costly, highly invasive, and carries a risk of iatrogenic damage. Pharmacological treatments, physical therapy, and modern rehabilitative training are characterized by prolonged treatment periods and slow efficacy. Especially for school-age children, a safe treatment method with minimal trauma, fewer side effects, good prognosis, and relatively short treatment period is needed. The treatment results of this case study suggest that acupuncture may facilitate nerve regeneration and improve muscle atrophy due to nerve loss. Acupuncture shows good therapeutic effects in the restoration of limb function in patients with common peroneal nerve injuries. It can be considered a viable treatment option that may reduce complications and expedite recovery.The functional and sensory improvements following acupuncture treatment for common peroneal nerve injuries warrant further investigation to clarify its applicability and to assist doctors and patients in optimizing treatment plans and course of treatment.References[1]GARRETT A, GEIGER Z. Anatomy, Bony Pelvis and Lower Limb,Calf Deep Peroneal (Fibular) Nerve[M]. In: StatPearls [Internet]. Stat-Pearls Publishing,2023:30252289.[2]HUCKHAGEL T, NUCHTERN J, REGELSBERGER J, et al.Nerve trauma of the lower extremity: evaluation of 60,422 leg injured pa-tients from the TraumaRegister DGU® between 2002 and 2015[J]. ScandJ Trauma Resus,2018,26(1):40.[3]HARDIN JM, DEVENDRA S. Anatomy, Bony Pelvis and Lower Limb, Calf Common Peroneal (Fibular) Nerve [M]. In: StatPearls [Inter-net]. Treasure Island (FL): StatPearls Publishing,2022:30422563.[4]George SC, Boyce DE. An evidence-based structured review to assess the results of common peroneal nerve repair. Plast Reconstr Surg. 2014;134(2):302e-311e. doi:10.1097/PRS.0000000000000318[5]Mingxing ZH ,Yi G, Yisidatoulawo, et al.Study on the Effects and Mechanism of Electroacupuncture Intervention on Peripheral Nerve Injury[J].World Chinese Medicine,2020,15(07):1003-1007.[6]Dimitrova A, Murchison C, Oken B. Acupuncture for the Treatment of Peripheral Neuropathy: A Systematic Review and Meta-Analysis. J Altern Complement Med. 2017;23(3):164-179. doi:10.1089/acm.2016.0155[7]Zhang ZD, Wang RQ, Liu JX, et al. Characteristics of clinical application of electroacupuncture therapy for peripheral neuropathy based on data mining. J Zhen Ci Yan Jiu. 2021;46(3):240-247. doi:10.13702/j.1000-0607.200638[8]Xie LY, Xie LY. Treatment of 40 cases of paralysis of common peroneal nerve with acupuncture and moxibustion. J Tradit Chin Med. 1983;3(3):233-236[9]Yao ZH, Yao XL, Wan SQ. Observation on 52 cases of paralysis of common peroneal nerve treated by acupuncture and plum-blossom needling. J Tradit Chin Med. 1984;4(2):97-100.[10]Yang LJ, Liu YL, Wang SB, Jin ZG. Clinical observation on common peroneal nerve palsy treated with comprehensive therapy. J Zhongguo Zhen Jiu. 2014;34(4):334-336.[11]Hao J, Zhao C, Cao S, Yang S. Electric acupuncture treatment of peripheral nerve injury. [J]. Tradit Chin Med. 1995;15(2):114-117.[12]Jin-xin W, Wen-shui W, Si-xiong L.Understanding of ”Arrival of Qi” Based on Soft Tissue Anatomy[J].Henan Traditional Chinese Medicine,2022,42(03):370-374.DOI:10.16367/j.issn.1003-5028.2022.03.0080.[13]Kim B.H. The effects of acupuncture at GB34 on disuse muscle atrophy in rats. J Korean Med Rehabil. 2018;28(4):1–9.[14]Jingyi ZH, Jianxin ZH, Yuanxiang T .A case study of low frequency continuous wave electroacupuncture combined with traditional Chinese medicine in treating common peroneal nerve injury[J].China’s Naturopathy ,2023,31(15):107-109+125.DOI:10.19621/j.cnki.11-3555 /r.2023.1532.[15]Brock Symons T, Park J, Kim JH, et al. Attenuation of skeletal muscle atrophy via acupuncture, electro-acupuncture, and electrical stimulation. Integr Med Res. 2023;12(2):100949. doi:10.1016/j.imr.2023.100949[16]Li H, PEITONG W, WEIBO ZH, et al.Effects of Low Frequency Electric Acupuncture on Different Months of Age - Related Rat Skeletal Muscle by TGF-β/Smad Signaling Pathway[J].Chinese Archives of Traditional Chinese,2018,36(09):2064-2067.[17]MINGWEI G, RUIXIN L, TAO L, et al.Observation of the Therapeutic Effects of Electrical Stimulation Combined with Mirror Therapy on Common Peroneal Nerve Injury[C].Proceedings of the 13th National Sports Science Conference - Special Report (Sports Medicine Section).China Sport Science Society,2023:3.DOI:10.26914/c.cnkihy.2023.063190.