Background Explore the possible mechanism of anti-influenza virus, based on the study of the active components-drug-target network, Protein-Protein Interaction (PPI) network and molecular docking verification, we explored the potential action mechanism of TCM in Chinese protocol for diagnosis and treatment of influenza 2019. Methods Screening the active components and potential targets of 12 drugs in the scheme by using TCMSP database, and Obtaining the target of influenza by GeneCard, Durgbank, OMIM, TTD and PharmGkb databases. Then, constructed the “component-durg-target” network and PPI network were by Cytoscape3.8.0 software. Morethan, analyzed and the biological function and pathway, verified the molecular docking by AutoDock Vina software. Results The 12 drugs in the recommended scheme (XBCQ) for severe influenza contain 192 active components and involve 31 key antiviral targets, which may play an antiviral role through biological processes such as lipopolysaccharide, pathogen molecular reaction and regulate signaling pathway via the IL-17, influenza A, TNF, Toll-like receptors. Conclusion TCM play critical therapeutic roles through “multi-components, multi-targets and multi-pathways” mechanisms in influenza infection. The antiviral pharmacological mechanism of Xuanbai Chengqi decoction, which was analyzed by network pharmacology and molecular docking, provide a new idea for further exploring the diagnosis and treatment of severe influenza.

Stable isotope analysis is a universally recognized and efficient method of indicating trophic relationships that is widely applied in research. However, variations in natural isotopic abundance may lead to inaccuracies due to the effects of complex environmental conditions. This research compared the carbon and nitrogen isotopic niches of fish communities between diverse biotopes around the Yellow River estuary and adjacent sea areas, with the aim of revealing distinctions in stable isotopic niche metrics, trophic positions, and feeding preferences. Stable isotopic niche results indicated that the communities of estuarine habitants were compatible in most study biotopes, and may provide a corridor for energy and material transportation between Laizhou Bay and the open water. Local biocoenosis was embodied in the wider isotopic niche corresponding to frequent environmental changes and abiotic gradients. This implied that they used various food sources to adapt to the fickle environment, including marine-terrestrial boundaries and the estuary. Our analysis of the food source contribution indicated that allochthonous sources were considered major energy sources in estuarine areas directly affected by Yellow River-diluted water, while autochthonous benthic and pelagic producers dominated carbon input into the food web in Laizhou Bay and the open water. A significant variation in the fish δ15N characteristic was found within estuarine adjacent regions, so, together with the results from previous studies, we deemed the local high concentration of dissolved inorganic nitrogen as the original trigger of the abnormal δ15N characteristic in fishes via a transport process along food chains. These results provide a new perspective on the natural distinction of carbon and nitrogen isotopic niches. The detailed data reported here enhance our understanding of variations in fish communities in estuarine ecosystems.

Objectives: Much less attention has been given to the right heart and pulmonary circulation compared to the left heart and systemic circulation in patients with pre-eclampsia (PEC). We used transthoracic echocardiography (TTE) to estimate pulmonary artery pressure and right ventricular function in women with PEC. Methods: A case-control study at a tertiary care academic center. Ten early PEC (<34 week gestation) and nine late PEC (≥34 weeks gestation) patients with eleven early and ten late gestational age-matched controls. Two dimensional TTE was performed on all patients. The estimated mean PA pressure (eMPAP) was calculated based on pulmonary artery acceleration time (PAAT). Pulmonary vascular resistance (ePVR) was estimated from eMPAP and right ventricular (RV) cardiac output. RV myocardial performance index (RV MPI), tricuspid annular plane systolic excursion (TAPSE), tissue tricuspid annular displacement (TTAD) and lateral tricuspid annular tissue peak systolic velocity (S’) were measured. Results Compared to early controls, in early PEC the eMPAP and ePVR were elevated, PAAT was reduced, RV MPI was increased, TTAD was reduced and TAPSE and TV S’ were unchanged. Compared to late controls, in late PEC, estimated MPAP and estimated PVR were elevated, PAAT was reduced and RVMPI was increased, while TAPSE, TTAD and TV S’ were unchanged. Conclusions: Early PEC is associated with increased eMPAP and ePVR. A subclinical decrement of RV function is noticed. TTE is a useful screening tool for early detection of PH and RV dysfunction in PEC.

1. Understanding the animal-habitat relationship at local scale is crucial in ecology, particularly to develop strategies for wildlife management and conservation. As this relationship is governed by environmental features and intra and inter-specific interactions, habitat selection of a population may vary locally between its core and edges. 2. This is particularly true for central place foragers, such as grey and harbour seals, whose trends in numbers vary among different regions in the Northeast Atlantic. Here, we aimed at studying how foraging habitat selection may vary locally with the influence of population trends and physical habitat features 3. Using GPS/GSM tags deployed in grey and harbour seal colonies of contrasting sizes, we investigate spatial patterns and foraging habitat selection by comparing trip characteristics and home range similarities, and fitting GAMM to the seal distribution and environmental data respectively. 4. We show that grey seal foraging habitat selection and spatial patterns differed markedly between regions. Grey seals may select environmental characteristics for their foraging habitat accounting for local differences in prey consumed. Spatial patterns were different might depend on local seal density and regional productivity, located from inshore to offshore areas for the limit ranges and core population respectively. Our results on foraging habitat selection reflected the coastal and sedentary behaviour of harbour seals. We found no difference in spatial patterns between colonies, except for the Inner Hebrides where seals foraged further, potentially reflecting density dependence pressure, as the number in this colony is higher. 5. These results suggest that local conditions might have a strong influence on population spatial ecology, highlighting as well the relevance of studying foraging habitat selection based on foraging behaviour at fine geographical scale, particularly if species are managed within regional units.

Rationale, aims and objectives: This study aimed to determine the residents’ perspectives on clinical practice during the pandemic of coronavirus disease 2019 (COVID-19). Methods: A cross-sectional survey was carried out online among medical residents in our hospital. The survey covered basic information, condition of clinical practice, and perspectives related to the COVID-19. Results: total 174 (26.8%) residents responded and completed the survey. Nearly half of the residents (51.7%) expressed willingness of going to the frontline to fight against the virus and 62.3% of the residents showed good morale. Online courses were delivered to 87.9% of the residents with satisfaction at 89.7%. Approximate one third of the residents concerned the impact of the epidemic on graduation (34.0%) and taking up an occupation (32.8 %). Majorities (79.3%) determined to be a doctor after the pandemic. Notablely 40.2% of the residents thought they were underpaid. 21.8% of the residents reported to be unfairly treated in clinical practice. Overall no statistical differences were revealed between internal medicine and surgery residents, and between those married and singles, regarding the perceptions related to the COVID-19. Conclusion: Administrators should take cognizance of perspective of the residents and formulate corresponding strategies to reassure trainees’ safety and continuous training, address the residents’ concerns and get prepared for the second wave of COVID-19.

Purpose Colon adenocarcinoma is the most common primary malignant tumor of the digestive tract. It is still important to find important markers that affect the prognosis of COAD. This research aims to identify some key prognosis-related metabolic genes (PRMG) and establish a clinical prognosis model for COAD patients. Method We used The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) to obtain gene expression profiles of COAD, and then identified differentially expressed prognostic-related metabolic genes through R language and Perl software, Through univariate Cox analysis and least absolute shrinkage and selection operator (LASSO) Cox analysis to obtain target genes, established metabolic genes prognostic models and risk scores. Through COX regression analysis, independent risk factors affecting the prognosis of COAD were analyzed, and Receiver Operating Characteristic (ROC) curve analysis of independent prognostic factors was performed and a nomogram for predicting overall survival was constructed. Perform the consistency index (C-index) test and decision curve analysis (DCA) on the nomogram, and use Gene Set Enrichment Analysis (GSEA) to identify the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway of model genes. Result We selected PRMG based on the expression of metabolic genes, and used LASSO Cox regression to construct 16 metabolic gene (SEPHS1, P4HA1, ENPP2, PTGDS, GPX3, CP, ASPA, POLR3A, PKM, POLR2D , XDH, EPHX2, ADH1B, HMGCL, GPD1L and MAOA) models. The risk score generated from our model can well predict the survival prognosis of COAD. A nomogram based on the clinicopathological characteristics and risk scores of COAD can personally predict the overall survival rate of COAD patients. Conclusion We comprehensively identified metabolic genes related to the prognosis of COAD. The risk score based on the expression of 16 metabolic genes can effectively predict the prognosis of patients with COAD.

Maturity-onset diabetes of the young (MODY) is a group of monogenic diabetes characterized by an autosomal dominant inheritance. MODY is categorized by a large variety of clinical forms and is caused by a wide spectrum of mutations in MODY‑related genes that lead to different clinical pictures and require distinct treatment

Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) of the breast is rare. We report a 59-year-old female with remote history of ductal carcinoma in situ treated with radiation and tamoxifen, who was recently diagnosed with CLL/SLL of contralateral breast after a localized suspicious cluster of masses was detected on routine mammography.

Cytopenias are common among neonates in neonatal intensive care units (NICU). Although, bone marrow aspirations (BMA) are often performed as part of diagnostic work up but trephine marrow biopsies (BMB) have not been reported from living neonates. BMB is indispensable to accurately assess the cellularity and architecture. There is paucity of literature regarding the technique of BMB in neonates. In this report, for the first time, we describe trephine BMB from Posterior superior iliac crest (PSIC) using 18 guage BMA needle in six living neonates admitted to NICU where bone marrow biopsy findings helped in understanding the underlying mechanism and diagnosis of cytopenias.

To study the fluidity and sprayability characteristics of sulfur powder, powder comprehensive characteristic tester was utilized. The results show that the fluidity was in not good level and prone to be sprayable. With the moisture content less than 1.2%, the fluidity property was also in not good level, and continuous increase in the moisture content or the charge-to-mass ratio tended to trigger off bad or even worse fluidity. When the moisture content of the wet basis was less than 0.7%, the sulfur powder was prone to spray. Raising the moisture content from 0.7% to 1.5%, or increasing the charge-to-mass ratio from -6.9 to -11.4 nC∙g-1 also led to may be sprayable tendency, while a further increase in one of the two parameters no sprayable tendency. It can be concluded that in the chemical industry, special treatment is needed for sulfur production equipment to improve its fluidity and sprayability.

First principles study of the partition function and heat capacity of OH − anion is conducted at high temperatures (2000K-10,000K). Firstly, with the quantum chemical ab inito methods (RASSCF with CASPT2 correction) were used to cal- culate potential energy curves of the ground and excited electronic states; the energy points were fitted to analytical representation of the curves. Secondly, the statistical thermodynamics calculations with the classical method with the quantum Wigner-Kirkwood correction were performed to obtain partition func- tion and heat capacity. Thermochemical tables and datasets usually give quantities up to 6000K (sometimes even more) and often are not reliable at the highest temperatures, it is shown that in particular electronic excited states could be missing. Parti- tion function is compared with the only available Barklem and Collet dataset. Discrepancies between heat capacity data (given in NIST-JANAF and Burcat databases) are pointed out - the inclusion of excited electronic states is crucial.

The coronavirus disease-2019 (COVID-19) pandemic has rapidly spread across the world. The disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which first appeared in Wuhan, China in December, 2019. Ever increasing data is emerging about COVID-19 and its effects on the arterial and venous circulation. Clinical features associated with COVID-19 suggest that endothelial cell dysfunction and microvascular thrombosis are to a large part contributing to resultant multi-organ complications. This review is aimed at highlighting the critical aspects associated with COVID-19 and its presumed microvascular angiopathic complications leading to multi-organ dysfunction.

The low-temperature transportation, a process of gathering and transportation at ultrahigh water content, can incline the energy consumption and elevate the efficiency of the surface gathering system. Here we found that there is the risk of wall sticking of heavy oil in the low-temperature transportation.In this work, a theoretical model of boundary condition for heavy oil in low-temperature transportation based on DLVO theory was proposed to predict the wall sticking occurrence temperature. The outcomes of modeling results had a good agreement in comparison with experiment results (error values: 0.1°C~1.5°C).Moreover, the interaction mechanism of wall sticking was correlated well with the Hamaker constant, radius of oil droplets, Ζeta potential, and Debye length.

Background: Aortic Valve Neocuspidization using glutaraldehyde-treated autologous pericardium was first performed by Ozaki et al. in 2007. This technique has become an alternative to tissue and mechanical valve as long-term anticoagulation is not required and shows promising midterm results and durability. Method: A comprehensive search was performed on the major database using search terms “Ozaki technique” AND “Aortic Valve Neocuspidization” AND “AV Neocuspidization” AND “Autologous pericardium” AND “glutaraldehyde-treated autologous pericardium”. Articles up to 1st of August 2020 were included in this study. Results: A total of 9 studies with a total of 1342 patients were included. The mean age was 67.36 and 54.23% were male. 66.32% and 23.92% of patients had aortic stenosis and aortic regurgitation, respectively. 66% of patients had a native tricuspid aortic valve and 31.37 % patients’ native aortic valve was bicuspid. Three studies reported their experience performing Aortic Valve Neocuspidization via mini sternotomy. Conclusion: Aortic Valve Neocuspidization is an alternative to biological and mechanical prostheses for surgical aortic valve replacement. The short and mid-term outcome are comparable without the need for long term oral anticoagulation. Long term follow-up data is required for this novel approach to be widely adopted.

For ascending aortic pseudoaneurysms with a large aortic entry site and thrombus burden, temporary stent-graft placement at induction of circulatory arrest can prevent thrombotic complication.

Sudden fractures in rigid ceramic filter tubes hinder the stable long-term operation of advanced power-generation processes. In this study, Time difference of arrival (TDOA) of dynamic pressure in the inner wall of filter during pulse jet cleaning process and outlet concentration with diameter of leakage during filtration and pulse jet cleaning process are investigated using high frequency sensors and optical particle spectrometry. The outlet concentrations measured under different leakage agreed with the theoretical values, with the peak outlet concentration being 2.5 times greater than stable outlet concentration. There is a linear relationship between leakage aperture and theoretical outlet concentration in leaking ceramic filter tubes. A positioning model that can precisely locate the leaking ceramic filter tube using the time difference in the dynamic pressure as measured at different positions is established. This research can quickly and accurately determine whether a ceramic filter tube is broken and location of breakage.

Hi,not sure if I am in the correct user interface because I cannot see the document I am commenting on.  However, I have it up in a different window.  My only comments are pretty minor.In the abstract, it has a lot of commas in the first sentence.    Perhaps replace the last comma with a hyphen at the end?   U.S. computing leaders, including the National Science Foundation, have partnered with universities, government agencies, and the private sector to accelerate research into responses to COVID-19 -- providing an unprecedented collection of resources that include some of the fastest computers in the world. 

This study aims to investigate the influence of sunlight on the photooxidation of tropical oils (TOs). Coconut oil (CNO), palm oil (PO), and palm kernel oil (PKO) were chosen for determining the indicators of photooxidation when exposed to and in the absence of sunlight for seven weeks. The results showed a significant (p < 0.05) increase in free fatty acid (FFA) levels and peroxide value (PV) when the TOs were exposed to sunlight. The iodine value (IV) and colour content decreased significantly (p < 0.05) due to the decomposition of unsaturated FFAs owing to the breaking-down of the π-bonds and the degradation of colour pigments during photooxidation. FTIR analysis showed strong vibrational absorptions at 1721 and 3505 cm-3, 1720 and 3560 cm-3, and 1721 and 3554 cm-3 for the CNO, PO, and PKO samples exposed to sunlight, respectively. These bands can be attributed to the presence of secondary oxidation products, which were absent in the TOs that were not exposed to sunlight. A simulation was performed to support the FTIR results, which also indicated peaks from the secondary oxidation products at 1744 and 3660 cm-3. The study also revealed that the rate of photooxidation was different for each TOs. The rate of oxidation followed the order PO > PKO > CNO. In contrast, no notable changes were observed in the TOs kept away from the sunlight. These results suggest that exposing TOs to sunlight influences their oxidation stability and quality.

Background: Coronavirus disease (COVID-19) has overwhelmed healthcare systems worldwide often at the cost of patients with serious non-COVID-19 conditions. Outcomes and risks of contracting COVID-19 in patients hospitalized during the pandemic are unknown. Objective: To report our experience in safely performing electrophysiology procedures during the COVID-19 pandemic. Methods: We examined non-COVID-19 patients who underwent electrophysiology procedures during the peak of the pandemic between March 16, 2020 and May 11, 2020 at seven Northwell Health hospitals. We developed a priority algorithm to stratify inpatients and outpatients requiring electrophysiology procedures and instituted a protocol to minimize hospital length of stay (LOS). All patients underwent post discharge 30-day tele-health follow-up and chart review up to 150 days. Results: A total of 217 patients underwent electrophysiology procedures, of which 86 (39%) patients were outpatients. A total of 108 (49.8%) patients had a LOS less than 24 hours, including 74 device implantations and generator changes, 24 cardioversions, five ablations, and one electrophysiology study. There were eleven (5.1%) procedure or arrhythmia related re-admissions and two (0.9%) minor procedural complications. Overall average hospital LOS was 83.4±165.1 hours and a median of 24.0 hours. For outpatient procedures, average hospital LOS was 9.4±13.4 hours and a median of 4.3 hours. Overall follow-up time was 83.9 ±42 days and a median of 84 days. During follow-up, two (0.9%) patients tested positive for COVID-19 and recovered uneventfully. No deaths occurred. Conclusion: During the peak of the COVID-19 pandemic, patients safely underwent essential electrophysiological procedures without increased incidence of acquiring COVID-19.

Background: Tumor positivity and upstaging rates from various surgical staging components performed in clinically early-stage epithelial ovarian carcinoma (EOC) vary widely in literature. Objectives: To quantify tumor positivity and upstaging rates for all staging surgery components in EOC patients. Differences between subgroups based on their clinical and histological characteristics are explored. Search strategy: A systematic search using synonyms of ‘ovarian cancer’, ‘neoplasm staging’, and ’neoplasm metastasis’ was conducted in PubMed, Embase, and the Cochrane Library. Selection criteria: Meta-analysis was performed on 23 included studies, comprising 5194 clinical stage I or II EOC patients who underwent comprehensive surgical staging. Data Collection and Analysis: Studies were assessed using the Newcastle-Ottawa Scale risk-of-bias tool. Pooled proportions and 95% confidence intervals were calculated using an inverse variance weighted random-effects model. Main Results: Overall upstaging rate of clinically early-stage EOC patients was 18.7% (95%CI: 14.1-23.4%). Serous histology or high grade EOC showed the highest upstaging rate at 35.3% (95%CI: 21.8-48.7%) and 40.9% (95%CI: 35.6-46.2%). Lymph node involvement resulted in an upstaging rate of 8.7% (95%CI: 6.2-11.3%). Tumor was identified in uterus, cytology, peritoneal biopsies, omentum and appendix in 6.2% (95%CI: 1.8-10.7%), 18.4% (95%CI: 13.8-22.9%), 9.7% (95%CI: 3.8-15.6%), 5.2% (95%CI: 1.7-8.8%) and 3.6% (95%CI: 0.0-7.5%) of EOC patients. The corresponding upstaging rates were 5.9% (95%CI: 1.4-10.4%), 8.5% (95%CI: 1.8-15.2%), 3.5% (95%CI: 1.0-6.0%), 3.9% (95%CI: 1.4-6.3%) and 1.6% (95%CI: 0.0-3.4%), respectively. Conclusion: The attributive value of comprehensive surgical staging in clinically early-stage EOC patients remains substantial, particularly in serous and high grade tumors.

Embolism spreading in dehydrating angiosperm xylem is driven by gas movement between embolised and sap-filled conduits. Here, we examine how proximity to pre-existing embolism and hydraulic segmentation affect embolism propagation. Based on the optical method, we compared xylem embolism resistance between detached leaves and leaves attached to branches, and between intact leaves and leaves with cut minor veins for six species. Moreover, we directly compared the optical and pneumatic method on detached leaves. Embolism resistance of detached leaves was significantly lower than leaves attached to stems, except for two species with all vessels ending in their petioles. Cutting of minor veins showed limited embolism spreading in minor veins near the cuts prior to major veins. Moreover, there was strong agreement in embolism resistance between the optical and pneumatic method, with minor differences occurring during early stages of embolism formation. We conclude that embolism resistance may represent a relative trait, depending on the proximity and connectivity to pre-existing embolism as a gas source. Since embolism formation may not rely on a certain pressure difference threshold between functional and embolised conduits, we suggest that embolism is facilitated by pressure-driven gas diffusion, while hydraulic segmentation can prevent embolism propagation by reducing gas diffusion.

Introduction: Ischemic cardiomyopathy (ICM) and idiopathic dilated cardiomyopathy (DCM) share common structural alterations with a high mortality from sudden cardiac death (SCD) and pump failure. Implantable cardioverter-defibrillator (ICD) has, since inclusion in international guidelines, been confirmed beneficial and cost-effective for primary prevention of SCD in patients with ICM, while huge debates in non-ischemic heart disease. This study was to compare the primary prophylactic value of ICD therapy in patients with ICM or DCM to identify a subgroup with greater advantage specially. Methods: We conducted a retrospective, single-center study, which enrolled 82 patients with ICM or DCM and guideline indications for primary prophylactic ICD or cardiac resynchronization therapy-defibrillator (CRT-D). Primary end-point was all-cause mortality and secondary outcomes included SCD and cardiovascular death. Results: During a median follow-up of 38.5 months, 78 patients baseline data were analyzable. The primary outcome occurred in 8 patients in ICM group and 5 patients in DCM group (p = 0.012). Cardiovascular death occurred in 5 patients in ICM group and 3 patients in DCM group [hazard ratio (HR) 0.119, 95% confidence interval (CI) 0.016-0.860, P = 0.035]. Resuscitated cardiac arrest or sustained ventricular tachycardia occurred in 4 patients in ICM group and 8 patients in DCM group (HR 0.294, 95% CI 0.040-2.144, P = 0.227). Conclusions: DCM patients with ICD implantation could gain more benefit with a reduction in the risk of all-cause mortality and cardiovascular disease compared with ICM patients, while the occurrence of SCD had no difference in two groups.

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By using the fixed point theorems, we give sufficient conditions for the existence and uniqueness of solutions for the nonlocal fractional boundary value problem of nonlinear Riesz-Caputo differential equation. The boundedness assumption on the nonlinear term is replaced by growth conditions or by a continuous function. Finally, some examples are presented to illustrate the applications of the obtained results.