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What is the optimal timing for Thoracic Endovascular Aortic Repair in uncomplicated T...
Matti Jubouri
Professor Mohamad Bashir

Matti Jubouri

and 7 more

November 10, 2021
Background: Uncomplicated Stanford Type B aortic dissection (un-TBAD) is characterised by a tear in the aorta distal to the left subclavian artery without ascending aorta and arch involvement. Optimised cardiovascular control (blood pressure and heart rate) is the current gold standard treatment according to current international guidelines. However, emerging evidence indicates that Thoracic Endovascular Aortic Repair (TEVAR) is both safe and effective in the treatment of un-TBAD with improved long-term survival outcomes in combination with optimal medical therapy (OMT) relative to OMT alone. However, the optimal timeframe for intervention is not entirely clarified. Aims: This review critically addresses current state-of-the-art comparing TEVAR with OMT and corresponding clinical outcomes for un-TBAD based on timing of intervention. Methods: We carried out a comprehensive literature search on multiple electronic databases including PUBMED and Scopus in order to collate all research evidence on timing of TEVAR in uncomplicated Type B aortic dissection. Results: TEVAR has proven to be a safe and effective treatment for un-TBAD in combination with OMT through comparable survival outcomes, improved aortic remodelling, and relatively low periprocedural added risks. Though the timing of intervention remains controversial, it is becoming clear that performing TEVAR during the subacute phase of un-TBAD yields better outcomes compared to earlier and delayed (>90 days) intervention. Conclusions: Further research is required into both short and long-term outcomes of TEVAR in addition to its optimal therapeutic window for un-TBAD. With stronger evidence, TEVAR is likely to be adopted as the gold-standard intervention for un-TBAD with definitive timeframe guidelines.
The Great Imposter: A case Report of IgG4 RD -Hypertrophic Pachymeningitis with Skull...
Muhammad Wadiwala
Liaquat Ali

Muhammad Wadiwala

and 3 more

November 10, 2021
Immunoglobulin G4-related disease is an inflammatory condition with unique clinical, serological, and pathological features. Here, we report a diagnostic challenging clinical case. Histopathology was used to diagnose his Ig4RD. This unique inature reinforces the fact that it is crucial to consider the diagnosis of IgG4-RD in those presenting with pachymeningiti
Second stage African Trypanosomiasis presented as Non Convulsive Status Epilepticus
Eetadal Ibrahim
Mohammed Gasm Elseed  M Elmahal

Eetadal Ibrahim

and 3 more

November 10, 2021
Human African Trypanosomiasis also known as sleeping sickness is a common disease in South Sudan. There are two recognized sstage, The early hemolymphatic stage and The late encephalitic stage when the CNS is involved specially with Gambians infection, broad neurologic spectrum has been reported such as psychiatric, motor, sensory.
Dementia as a core clinical feature of a patient with aceruloplasminemia
Farzad Ashrafi
Mehri  Salari

Farzad Ashrafi

and 3 more

November 10, 2021
Aceruloplasminemia is an autosomal recessive disease, caused by systemic iron accumulation due to mutations in the Ceruloplasmin gene. We report two Iranian siblings who have diagnosed with aceruloplasminemia. Based on our researches, dementia hasn't been published as the first neurological feature while one of them was presented with pure dementia
Comparisons of urine protein-to-creatinine ratios and their dynamic change patterns d...
Po-Hui Wang
PeiYin Yang

Po-Hui Wang

and 3 more

November 10, 2021
Objective to compare the urine protein-to-creatinine ratios (uPCRs) during labor at term between normal and women with pregnancy-induced hypertension (PIH), and to evaluate the patterns of change in uPCRs. Design observational study Setting Tertiary referral hospital in Taiwan Population normal pregnant or women only with PIH at term were enrolled Methods and Main outcome measures uPCRs in four phases (latent, active, recovery and early postpartum) and related clinical data at delivery were collected. Multivariate analysis with a linear regression model were performed to analyze continuous variables after adjusting for clinical data between two groups. Results 68 normal and 24 pregnant women with PIH were included. There were no differences in the uPCR or the proportion cases of uPCRs ≥ 300 mg/g between normal and PIH group in the latent, active, recovery or early postpartum phases. There was a statistically significant tendency for the proportion of uPCRs ≥ 300 mg/g to increase from the latent to the early postpartum phase in both groups. The proportion of uPCRs ≥ 300 mg/g significantly increased from the active to the recovery phase and then declined from the recovery to the early postpartum phase in normal pregnant women.Thus no differences in uPCRs cases change between any two phases in women with PIH, except the duration above stated. Conclusion. This is the first study to demonstrate that uPCRs data are not different between normal pregnant and PIH groups during the course of labor, but it did show different dynamic change patterns throughout the labor phases.
Hypoxemia indicative of Rendu Osler disease during SARS Cov-2 pandemic
Herveat RAMANANDAFY
Princy Parfait  Andriamahenina

Herveat RAMANANDAFY

and 10 more

November 10, 2021
Rendu Osler's disease is a genetic disease characterized by mucocutaneous and visceral telangiectasias. Rendu Osler's disease was discovered during hypoxemia during an outbreak of SARS-Cov2.This was a 36-year-old woman with exertional dyspnea and severe hypoxemia revealing pulmonary arteriovenous malformations on chest CT scan.
RIGHT ATRIAL STRAIN IN A NORMAL ADULT AFRICAN POPULATION AND ITS CORRELATION WITH AGE
Mushitu Nyange
Ruchika Meel

Mushitu Nyange

and 1 more

November 10, 2021
Background The right atrial longitudinal strain (RALS) has been shown to be a useful parameter to define right atrial (RA) subclinical dysfunction in several cardiovascular disorders prior to changes in traditional RA two dimensional and volumetric parameters. There is a scarcity of data regarding normal values for RALS in a normal African population. Objectives We sought to establish normal values for RALS and its correlation with age, in a Sub-Saharan black African population. Methods This was a retrospective cross-sectional study of 100 normal individuals (recruited as controls for another study) performed at Chris Hani Baragwanath Hospital (2017-2019). All echocardiographic measurements were done as per standard guidelines. RALS was measured using Philips QLAB 9 (Amsterdam, The Netherlands) speckle-tracking software. Results Median age was 37.5 years (IQR 26- 46, 60% females). The mean right atrial volume indexed to body surface area (RAVI) was 19.5 ± 5.7 mL/m 2 and the mean RALS was 32.7 ± 10.5%. There was a trend towards decreasing RALS with age (r=-0.15, P=0.129) with no change in RAVI with age ( P=0.27). Males had a tendency towards higher RAVI and RALS measurements compared to females (20.8 ± 6.3 mL/m 2 and 18.7 ± 5.2 mL/m 2, P=0.07: 34.6 ± 9.6% and 31.4 ± 10.9 %, P=0.141, respectively) . BMI was an independent predictor of RALS on multivariate analysis ( r= -0.43, P =0.003) Conclusion We have defined the normal reference values for RALS in a black population. RALS tended to decrease with age prior to change in RAVI and can serve as a marker of subclinical RA dysfunction . BMI was an important determinant of RALS.
Dose Banding -- weighing up benefits, therapeutic failure and risks
Stephen Duffull

Stephen Duffull

November 10, 2021
Aim Dose banding is a commonly used method of dose individualisation in which all patients with similar characteristics are allocated to the same dosing group. Dose banding results in some patients receiving less intensive treatment with the potential for a reduction in therapeutic benefit (iatrogenic therapeutic failure). This study aims to explore the effects of dose banding on therapeutic success and failure. Methods This was a simulation study conducted using MATLAB. Virtual patients were simulated under a simple pharmacokinetic model with a predefined target steady-state average concentration (c_(ss,ave)). Clearance was correlated with a covariate used for dosing. Dose individualisation was based on: one-dose-fits-all, covariate based dosing, empirical dose banding, dose banding optimised for benefit:risk only and dose banding optimised for both benefit:risk and minimising iatrogenic therapeutic failure. Results The lowest and highest probabilities of target attainment (PrTA) were 46% for one-dose-fits-all and 72% for fully individualised covariate-based dosing. Neither dosing approach would result in iatrogenic therapeutic failure as lower dose intensities do not occur. Empirical dose banding performed better than once-dose-fits-all with 59% PTA but not as good as either optimised method (64-69% PrTA) while carrying a risk of iatrogenic therapeutic failure in 25% of patients. Optimising for benefit:risk (only) improved PrTA but carried a risk of iatrogenic therapeutic failure of up to 10%. Optimising for benefit:risk and minimising iatrogenic therapeutic failure provided the best balance. Conclusion Future application of dose banding needs to consider both the probability of benefit:risk as well the risk of causing iatrogenic therapeutic failure.
Statin and Post-Cardiac Surgery Atrial Fibrillation Prevention: Systematic Review and...
Federico Oliveri
Andrea Bongiorno

Federico Oliveri

and 6 more

November 10, 2021
Introduction: Postoperative atrial fibrillation (POAF) is a frequently reported complication of cardiac surgery, leading to increased in-hospital and long-term mortality rates. Many studies have suggested using statins to protect against POAF. Thus, we aim to investigate if statin pre-treatment may effectively lower the incidence of POAF. Method: We performed a systematic literature search of PubMed for potential studies between January 2006 and August 2021. Principal inclusion criteria were: randomized clinical trials study design; statin-naive patients; total study participants ≥ 50 units. We used the fixed-effects model to obtain the odds ratio (OR) and 95% confidence interval (CI) for each analyzed intervention. Results: Overall, statin pre-treatment reduced the incidence of POAF compared to placebo (OR 0.71; 95% CI: 0.60-0.85, p-value < 0.00001). Analyzing subclasses, atorvastatin was associated with lower incidence of POAF (OR 0.54; 95% CI: 0.41-0.70, p-value = 0.002), but rosuvastatin was not (OR 0.90; 95% CI: 0.71-1.14, p-value = 0.38). Selecting studies with ≥ 199 patients, results were divergent. There was not statistically significant difference between statin pre-treatment and placebo (OR 0.89; 95% CI: 0.74-1.09, p-value = 0.26), as well as for atorvastatin (OR 0.74; 95% CI: 0.54-1.03, p-value = 0.08) and rosuvastatin (OR 0.87; 95% CI: 0.68-1.12, p-value = 0,29). Conclusion: Statin pre-treatment before cardiac surgery is not associated with a significant reduction in POAF occurrence. Thus, based upon our results and considering possible renal complications, we discourage statin pre-treatment in preventing POAF.
Using low cost materials for highly efficient eco-friendly FASnI3 based solar cell wi...
M Vishnuwaran
K Ramachandran

M Vishnuwaran

and 4 more

November 10, 2021
Perovskite materials are considered the mainstay of PV manufacturing asoutstandingto notable optoelectronic properties. In this work the act of Pb-free FASnI3 based PSC, TiO2 as ETL, and Cu2O as HTL and Ag,Au, Pt,are the different metal contact is simulated using SCAPS software. Here we focused on the impactparameters of device such as the thickness of the Ab-Layer, doping level ofperovskite layer and different working temperature. Additionally, we investigated the effect of different metal contact and their work function. The simulated results show that a perovskite layer thickness of 350nm for good perovskite solar cell. For optimizing parameters, efficiency 18.10%, FF 78.14, Jsc 29.61, and Voc 0.7821 have been achieved for Cu2O and TiO2 respectively. The thermal study shows that device configurations for this present work at 300k it is stable for this entire work.
Famiglia e Medicina Generale: un’indagine esplorativa.
Alessandro Addorisio

Alessandro Addorisio

February 04, 2024
IntroduzioneIn questi mesi così complicati e tragici in molti cercano di scorgere qualcosa di positivo nella pandemia, ad esempio la presunta maggiore solidarietà fra i cittadini oppure l’inizio di una nuova era di collaborazione sovranazionale per fini sanitari, con l’obiettivo di una salute globale e universale. Una salute universale per la quale però occorre che ogni sistema nazione sia dotato di capacità collaborative ed evolutive.  E’ triste constatare che occorreva una pandemia globale per ricordarci l’importanza per ogni Stato di avere un servizio sanitario efficace e pubblico, in grado di preservare la salute dei cittadini. Inoltre il Covid-19 ha costretto molti Stati, e di conseguenza i suoi cittadini, ad adottare nuove forme di cura e assistenza, dall’aiuto reciproco al distanziamento sociale e all’auto-isolamento per tutelare la salute altrui, oltre che la propria. Un modo di concepire l’idea di salute che si sposta dalla sfera individuale a quella collettiva della comunità e che mette in evidenza la crisi di un assistenza basata su servizi di tipo aziendalistico come il Servizio Sanitario Nazionale e l’esigenza di nuovi modelli flessibili e sistemici ovvero di un Sistema sanitario Nazionale.Queste nuove forme di cura dell’Altro, nel senso più ampio del termine, mettono in discussione decenni di riduzione del welfare e della solidarietà, in nome di un individualismo che negli ultimi tempi ha assunto nuove denominazioni e descrizioni, come i concetti di benessere della persona, di autocura e, per ultimo, di resilienza. Quest’ultimo termine in particolare è diventato una sorta di mantra negli ultimi anni per indicare la capacità di riprendersi da eventi dannosi ma che, soprattutto se usato in riferimento all’individuo, lo responsabilizza nei confronti di una mancata capacità di opporsi ad eventi avversi, quasi che la famigerata resilienza sia una dote innata, un talento che si possiede oppure no e non invece una condizione, una contingenza di più fattori, alcuni individuali ed altri sociali, culturali ed economici.Queste denominazioni, questi concetti nuovi o antichi, vengono promossi da un mondo politico- economico-industriale che, sebbene si debba riconoscere la necessità di tenere i conti pubblici sotto controllo, ha evidenziato i suoi  limiti intrinseci, come l’idea di voler ridurre la cura e l’assistenza a qualcosa che si può, o si deve, acquistare secondo le proprie possibilità e non considerarle invece un diritto universale, come garantito dalla nostra Costituzione.L’altro aspetto “positivo” della pandemia dovuta al Covid 19 è l’aver dimostrato la profonda interdipendenza che esiste in campo medico e sanitario non solo a livello locale ma anche globale. Non sempre questo aspetto viene colto soprattutto dagli organi di informazione e dai social-network, anzi a volte essi concorrono a diffondere pregiudizi e paure che diventano terreno fertile per politiche di protezione nazionalistiche, se non addirittura discriminatorie e razziste. 112021 -Maria Paola Pofi, Leung Wing-Fai, Responses to health risk and suffering: ‘China’ in the Italian media discourses during the early stage of the Covid-19 pandemic . Journals.sagepub.com.Se il Covid 19 non sarà reso innocuo a livello mondiale prima o poi le sue varianti torneranno a diffondersi a dispetto di qualsiasi frontiera, fisica o politica. Ma anche a livello locale occorre la collaborazione fra tutti per ridurre i rischi di contagio, come ha dimostrato l’efficacia delle misure di sanità pubblica, integrandole magari con l’uso di metodiche che facilitino il cambiamento culturale nei soggetti più dubbiosi o restii ad accettare tali misure.Per valutare e approfondire queste interdipendenze è opportuno avere uno sguardo di tipo sistemico, che non si focalizzi né sull’ estremamente ampio né sul particolare circoscritto. Uno sguardo che sappia variare la propria messa a fuoco, così come fa un’ottica zoom in campo fotografico, passando dalla visione grandangolare, ampia e panoramica, al  dettaglio minuto che permette un teleobiettivo.
Novel PKLR missense mutation (A300P) causing pyruvate kinase deficiency in an Omani K...
Naglaa Fawaz
Ismail Beshlawi

Naglaa Fawaz

and 8 more

November 10, 2021
A 15 year child is presented with transfusion dependent chronic anemia. The clinical and laboratory features suggested a chronic nonspherocytic hemolytic anemia (CNSHA) with bone marrow suggestive of congenital dyserythropoietic anemia (CDA). DNA studies revealed the underlying novel mutation in the PKLR gene responsible for pyruvate kinase deficiency.
TAFRO syndrome: a case report
Shan Meng
Hailing Liu

Shan Meng

and 7 more

November 10, 2021
A man diagnosed as TAFRO syndrome was successfully responded to a novel immunosuppressive regimen containing methylprednisolone and mycophenolate mofetil. Blood cells firstly recovered, followed by the general situation and complete recover 1 month later, highlighting the danger of TAFRO syndrome and the importance of immunosuppressive agents in reversing pathological course
Transformation of the acute myeloid leukemia to acute B cell lymphoblastic leukemia w...
Yanan Zhang
Fengan Liu

Yanan Zhang

and 7 more

November 11, 2021
Lineage conversion is used to describe acute myeloid or lymphoid leukemia becomes the opposite at relapse.We report a 4-year-old child with acute myeloid leukemia who was converted to acute lymphoblastic leukemia at relapse and received chimeric antigen receptor T (cell) therapy for reference.
Beneficial effects of pyruvate for a high-density perfusion process
Stefania Caso
Mathieu Aeby

Stefania Caso

and 4 more

November 10, 2021
High volumetric productivities can be achieved when perfusion processes are operated at high cell densities. Yet it is fairly challenging to keep high cell density cultures in a steady state over an extended period. Aiming for robust processes, in this study cultures were operated at a constant biomass specific perfusion rate (BSPR). The cell density was monitored with a capacitance probe and a continuous bleed maintained the cell density at the targeted viable cell volume (VCV). Despite our tightly controlled BSPR, a gradual accumulation of ammonium and changes in cell diameter were observed during the production phase for the three different monoclonal antibodies (mAbs). Although a lot of efforts in media optimization have been made to reduce ammonium in fed-batch process, less examples are known about how media components impact the cellular metabolism and thus the quality of monoclonal antibodies in continuous processes. In this work, we show that a continuous Na-pyruvate fed at 2 g/L/day strongly reduced ammonium production and stabilized fucosylation, sialylation and high mannose content for three different mAbs.
Grain carbon isotope composition is a marker for allocation and harvest index in whea...
Jean-Baptiste Domergue
Cyril Abadie

Jean-Baptiste Domergue

and 15 more

November 10, 2021
The natural 13C abundance (δ13C) in plant leaves has been used for decades with great success in agronomy to monitor water use efficiency and select modern cultivars adapted to dry conditions. However, in wheat, breeding also implies looking for genotypes with high carbon allocation to spikes and grains, and thus with a high harvest index and/or low carbon losses via respiration. Finding isotope-based markers of optimal carbon partitioning to grains would be extremely useful since isotope analyses are inexpensive and can be performed routinely at high throughput. Here, we took advantage of a set of field trials made of more than 600 plots with several wheat cultivars and measured agronomic parameters as well as δ13C values in leaves and grains. We find a linear relationship between the apparent isotope discrimination between leaves and grain (denoted as Δδcorr), and the respiration use efficiency-to-harvest index ratio. It means that overall, efficient carbon allocation to grains is associated with a small isotopic difference between leaves and grains. Our results show that 13C natural abundance in grains has some potential to help finding genotypes with better carbon allocation properties and assisting current wheat breeding technologies
IgE sensitisation predicts threshold but not anaphylaxis during oral food challenges...
Paul Turner
Bettina Duca

Paul Turner

and 6 more

November 10, 2021
Predicting reaction threshold and severity are important to improve the management of food allergy, however the determinants of, and relationship between, these parameters are significant knowledge gaps. Identifying robust predictors could enable the reliable risk-stratification of food-allergic individuals. In this series of young people with CM-allergy undergoing DBPCFC – the largest reported in the literature – we did identify any baseline marker which predicted the occurrence of anaphylaxis at challenge, consistent with existing data. 1 There is one report of IgE-sensitisation being predictive of severity in CM-allergy, 5 however the authors included non-reactive patients in their analysis which significantly skewed the analyses, resulting in misleading conclusions. 6 IgE-sensitisation in our cohort, particularly to casein, was predictive of LOAEL. Including an assessment of casein IgE may therefore be of clinical utility when evaluating patients with CM-allergy in the clinical setting.
Variant-level Matching Tools
Eliete   Rodrigues
Sean Griffith

Eliete Rodrigues

and 16 more

November 09, 2021
Here we describe MyGene2, Geno2MP, VariantMatcher, and Franklin; databases that have made variant-level information together with phenotype or phenotypic features available to researchers, clinicians, health care providers and patients. Following in the footsteps of the Matchmaker Exchange project that connects exome, genome, and phenotype databases at the gene level, these databases plan to connect to each other using Data Connect, a standard for discovery and search of biomedical data from the Global Alliance for Genomics and Health (GA4GH).
Apical vs subclavian transcatheter aortic valve implantation: an 8-year United Kingdo...
Francesca D'Auria
Danilo Flavio Santo

Francesca D'Auria

and 6 more

November 09, 2021
Objectives: Subclavian (SC) and transapical (TA) approach are the main alternatives to the default femoral delivery for transcatheter aortic valve implantation (TAVI). Aim of this study was to compare, complications and morbidity/mortality associated with SC and TA in a long-term time frame. Methods: From January 2007 to July 2015, 1,506 patients underwent TAVI surgery in 36 United Kingdom TAVI centres. Primary outcomes were complications according to VARC-2 criteria. The secondary outcome was long-term survival. Results: The enrolled patients were distributed as follows: 1,216 in the trans-apical (TA) group and 290 in the subclavian (SC) group. There were no differences in the rates of acute myocardial infarction, emergency valve-in-valve, paravalvular leak, balloon post dilatation, cardiac tamponade, stroke, renal replacement therapy, vascular injuries, and 30-days mortality among the groups. Conversely, the rate of permanent pacemaker implantation (p = 0.02), the procedural time duration (p = 0.04), and the 12-month mortality (p = 0.03) was higher in SC than in TA, while in-hospital length of stay was reduced in SC than in TA (p = 0.01). Up to 8-years, the long-term mortality was not different among groups (p = 0.77), and no difference in long-term survival between self vs balloon expandable device was found (p = 0.26). Conclusions: According to our results, TA provided the best 12-months survival compared to SC, while the long-term survival up to 2, 900 days is not significantly different between groups, so SC and TA may both represent a safe non-femoral access if femoral is precluded.
Role of chlorine, bromine, iodine, and dehalogenation in the fluorinated small molecu...
Alessandro Romo-Gutierrez
Zuriel Cisneros-Garcia

Alessandro Romo-Gutierrez

and 2 more

November 09, 2021
In a recent experimental investigation, the chlorination of the highly efficient Y6 fluorinated molecule improved up to 16.5 \% the power conversion efficiency of an organic solar cell. To understand the better performance of BTP-4Cl:PBDB-TF acceptor-donor combination in comparison with BTP-4F:PBDB -TF in the newly reported organic solar cell, DFT calculations were performed in order to obtain a diversity of parameters related to molecular proper ties, such as electroacceptance, electron energy levels, absorption spectrum, charge mobility, and kinetics in exciton dissociation/recombination processes. Interestingly, chlorination improves charge mobility and the capacity to accept electrons. The binding energy is lower for the chlorinated than the fluorinated molecule, revealing an easier exciton cleavage in the former. Absorption spectra are in line with experimental ones, suggesting an ex cellent donor-acceptor complementarity. Additionally, novel molecules were proposed taking into account synthesized compounds, and the same parameters were analyzed. Results showed exciting behavior for the theoretically suggested compounds. Many properties were improved with the proposed molecules, which can also be exploited in solar photocells. Although it is a challenge to simulate/model a complete photoactive layer of an organic solar cell, it is proved through electronic structure calculations that the properties of the materials involved in the photovoltaic device can be obtained. In this way, give some light on the power conversion efficiency comparison and propose new compounds.
Compound motor action potentials in transient and persistent phrenic nerve injury - m...
Marcin Kuniewicz
Marcin Kowalski

Marcin Kuniewicz

and 1 more

March 01, 2023
Background: The right phrenic nerve is vulnerable to injury (rPNI) during cryoballoon ablation (CBA) isolation of the right pulmonary veins. The complication can be transient or persistent. The reported incidence of rPNI fluctuates from 4.73% to 24.7% depending on changes over time, CBA-generation, and selected protective methods. Methods: Through September 2019, a database search was performed on MEDLINE, EMBASE, and Cochrane Database. In the selected articles, the references were also extensively searched. The study provides a comprehensive meta-analysis of the overall prevalence of rPNI, assesses the transient to persistent PNI-ratio, the outcome of using compound motor action potentials (CMAP), and estimated average time to nerve recovery. Results: From 2008 to 2019, 10,341 records from 48 trials were included. Out of 783 eighty- PNI (7.7%), 589 (5.7%) were transient, and 194 (1.9%) were persistent. CMAP caused a significant reduction in the risk of persistent PNI from 2.3% to 1.1% (p = 0.05; odds ratio [OR] 2.13) in all CBA groups. The mean time to rPNI recovery extended beyond the hospital discharge was significantly shorter in CMAP group at three months on average versus non CMAP at six months (p = 0.012). CMAP (in contrast to non-CMAP procedures) detects PNI earlier from 4 to 16 sec (p < 0.05; I2 = 74.53%) and 3 to 9º (p < 0.05; I2 = 97.24%) earlier. Conclusions: rPNI extending beyond hospitalization is a relatively rare complication. CMAP use causes a significant decrease in the risk of prolonged injury and shortens the time to recovery
The direct and legacy effects of drying-rewetting cycles on active and relatively res...
Shuai Zhang
Junjie Lin

Shuai Zhang

and 3 more

November 09, 2021
Global climate change is expected to increase the frequency of drought and heavy precipitation, which could create more frequent drying-rewetting cycles (DWC) in the soils. Although DWC effects on SOC decomposition has been widely studied, the effect of DWC and the subsequent legacy effect on the decomposition of different SOC pools is still unclear. We conducted a 128-d laboratory incubation to investigate the DWC effects by using soils from old-field for 15 years (OF, representing active SOC), bare-fallow for 15 years (BF), and bare-fallow for 23 years plus extra 815-d incubation (BF+, representing relatively resistant SOC). The experiment included nine 10-d DWC of three treatments: 1) constant-moisture at 60% WHC, 2) mild DWC with 10-d drying to 40% WHC and rewetting to 80% WHC, and 3) strong DWC with 10-d drying to 20% WHC and rewetting to 100% WHC. Following DWC period, there was a 10-d stabilization period (adjusting all treatments to 60% WHC), and then a 28-d extended incubation. During DWC period, the strong DWC had strong effect on CO2 release compared with the constant-moisture control, reducing the SOC decomposition from OF by 8% and BF by 10%, while increasing the SOC decomposition of BF+ by 16%. During extended period, both mild and strong DWC significantly increased SOC mineralization of OF, but decreased that of BF and BF+. This legacy effect compensated the changes in CO2 release during DWC period, resulting in the minor response of SOC decomposition of OF and BF+ to the DWC during the entire incubation.
Epulis gravidarum with histological features of plasma cell granuloma associated to h...
Dewi Zakiawati
Irna Sufiawati

Dewi Zakiawati

and 1 more

November 09, 2021
Hormonal imbalance during the pregnancy may predispose a localized gingival enlargement called epulis gravidarum. This paper aims to elaborate on a case of epulis gravidarum with histological features of plasma cell granuloma. Theoretically, they present in different histological features. However, in this case, the histological examinations showed both entities.
Is single-point acupuncture effective in treating acute low back pain? A case report
Sagun Tiwari
Namrata Sapkota

Sagun Tiwari

and 1 more

November 09, 2021
Acupuncture is often used for acute and chronic low back pain; however, its efficacy is controversial, primarily for acute low back pain (ALBP). Our case study suggests that single acupuncture could relieve ALBP within a short time without any adverse events.
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