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Noncirrhotic Portal Hypertension Secondary to Portal Vein Aneurysm
Yunus Catma
Gulcan Yildiz

Yunus Catma

and 6 more

September 16, 2022
We present a case of symptomatic, non cirrhotic portal hypertension secondary to Portal Vein Aneurysm of 3.7 cm diameter. It presented as dyspepsia. It was diagnosed during an ultrasound colour doppler. Medical therapy was prescribed with close follow up of the patient.
Impact of Corona pandemic on operations and supply chain of Agriculture and Food Proc...

Rajat K Baisya

September 16, 2022
This article attempts to assess the impact of Corona pandemic on businesses with particular reference to Agriculture and Food processing industries in MSME sector in India and tracing the possible recovery in terms of recreating the lost demand in domestic as well as in international markets. The industries were caught unaware to face the challenges of disruption with sudden announcement of lockdown and the resulting consequences. Industries in MSME sector depends on the functioning of large processors as their support and contract manufacturers as well as on their limited market opportunities which they have developed. During pandemic both collapsed. With the drastic reduction in consumption expenditure and disruption in supply chain coupled with the severe cash crunch, MSME sector has suffered the most. While the impact of COVID-19 on food and agricultural sector was less when compared with other sectors but even in this sector for MSME it was devastating. This article attempts to trace the reasons and estimating the magnitude of the impact and the possible way forward.
Pediatric Refractory Immune Thrombocytopenia: a Systematic Review
Layan Ibrahim
Selina Dong

Layan Ibrahim

and 9 more

September 16, 2022
Pediatric immune thrombocytopenia (ITP) is an acquired disorder associated with autoimmune destruction and impairment of platelet production in children. Some children exhibit poor or transient response to ITP-directed treatments and are referred to as having refractory ITP (rITP). There is currently no consensus on the definition of rITP, nor evidence-based treatment guidelines for patients with rITP. After a survey of pediatric ITP experts demonstrated lack of consensus on pediatric rITP, we pursued a systematic review to examine the reported clinical phenotypes and treatment outcomes in pediatric rITP. The search identified 253 relevant manuscripts; following review, 11 studies proposed a definition for pediatric rITP with no consensus amongst them. Most definitions included sub-optimal response to medical management, while some outlined specific platelet thresholds to define this sub-optimal response. Common attributes identified in this study should be used to propose a comprehensive definition, which will facilitate outcome comparisons of future rITP studies.
B- Acute Lymphoblastic Leukaemia in A Boy With Xeroderma Pigmentosum
Ajay Sankar
Guruprasad C S

Ajay Sankar

and 6 more

September 16, 2022
Xeroderma pigmentosum (XP) is an autosomal recessive disorder caused by defect in nucleotide excision repair and is associated with increased incidence of skin cancer. Lymphoblastic leukemia in XP is rare. We report a case of a 11-year-old boy with XP, who developed B – Acute lymphoblastic leukaemia (ALL). He was started on Modified BFM (Berlin-Frankfurt-Münster) ALL Protocol. Tolerance to ALL chemotherapy was good in our XP patient except for the transient derangement of liver function tests during induction, Pseudomonas sepsis and oral mucositis during protocol M and hyperbilirubinemia during maintenance chemotherapy. Though rare, children with XP requires to be investigated for acute leukaemia on development of bicytopenia.
Composition and phylogenetic structure of Pampean Grasslands under distinct land use...

Neil Damas de Oliveira Junior

and 2 more

September 19, 2022
Alien species can modify ecosystem functions and ecological processes in natural communities, and potentially become invasive. In the Brazilian Pampean grasslands, reports of changes in land use and invasions of alien plant species are becoming more frequent. This study aimed to investigate species composition and phylogenetic relationships between native and alien plants across four sites of Brazilian Pampean grasslands under distinct land uses (NOM: no agricultural management; GRZ: grazed pastures; AGR: agrarian crops; ROAD: roadside). The phylogenetic relationship between native and alien species was analyzed at two scales: inter-site (large scale) and intra-site (small scale). We found inter-site differences in phylogenetic diversity. Overall, across all sites we found random phylogenetic relationships among alien and native species. In the most disturbed site (ROAD) we found significant phylogenetic clustering among all species (alien and natives), while at the small scale, clustering was only found among natives. We conclude that clustering of phylogenetic relationships among alien and native species is only evident at small sampling scales in environments subject to high levels of disturbance (i.e., road sides) in the studied Pampean Grasslands, suggesting that environmental filtering plays an important role in local community assembly.Keywords: disturbance, land use, phylogenetic pattern, plant invasion, native communities
Positive end-expiratory pressure during Helmet ventilation in critically ill bronchio...
emanuele rossetti
Zaccaria Ricci

emanuele rossetti

and 19 more

September 16, 2022
Objectives: To evaluate the effects of two different levels of positive end-expiratory pressure (PEEP) during helmet continuous positive airway pressure (HCPAP) support on the intubation rate in infants with bronchiolitis admitted to pediatric intensive care units (PICUs). Design: Multicentric prospective, randomized, open clinical trial. Setting: Four tertiary PICUs in Italy. Participants: Infants admitted to PICUs due to severe bronchiolitis and requiring respiratory support. Interventions: The enrolled patients were randomly assigned one of two PEEP levels for HCPAP support: high (P10 group: 10 cmH 2O) or low (P5 group: 5 cmH 2O). Measurements and Main Results: In total, 64 patients were randomly assigned to the P10 group, and 60 to the P5 group. The intubation rate was 9/60 (15%) and 9/64 (14%) in P5 and P10 groups (OR 0.94, 95% CI 0.36-2.46, p=0.99). Of the patients in the P5 group, 47 (78%) were escalated to a PEEP level of 10 cmH 2O. PEEP level was not associated to intubation rate (OR 0.69, 95% CI 0.19 to 2.40, p=0.57), after adjustment for age, gestational age, high flow nasal cannula application, bronchiolitis severity score and pediatric index of mortality 3. No cases of pneumothorax were observed in this study. Conclusions: In this trial on infants with severe bronchiolitis, a PEEP level of 10 cm H 2O during HCPAP in comparison to an initial level of 5 cm H 2O did not show to prevent intubation. These results are not conclusive due to the premature stopping.
Strategies for Managing Neonates with Congenital Lung Mass Presenting with Respirator...
chang xu
Taozhen He

chang xu

and 7 more

September 16, 2022
Introduction: It is rarely seen that neonates with congenital lung mass presenting with respiratory distress require emergency intervention. No consensus has been achieved concerning the best policy facing such condition. This study aims to evaluate the efficacy and safety of our strategies in managing neonates with congenital lung mass presenting with respiratory distress. Methods: We retrospectively reviewed the data of five congenital lung mass (CLM) neonates presenting with respiratory distress from April 2020 to April 2022 for whom different strategies were adopted and favorable outcomes were obtained. The relevant data was reviewed and analyzed. Results: All the patients were prenatally diagnosed with CLM, and among them, four neonates with cystic lung masses accepted percutaneous thoracic catheter drainage prior to surgery. The first neonate with macrocystic lung mass experienced prompt open lobectomy due to failure of drainage. The other three patients obtained good drainage of the large air-filled cyst, thus gaining the opportunity for elective thoracoscopic surgery in median 48 d. The fifth patient directly underwent emergency surgery due to the solid nature of the lung lesion. Conclusions: For neonates with cystic lung masses presenting with respiratory distress due to mediastinal compression, percutaneous thoracic catheter drainage and subsequent elective thoracoscopic surgery were superior to emergency thoracotomy in terms of safety and parenchyma-sparing surgery based on the study and literature. For those with solid lung lesions whose CVR value is no less than 1.6, either EXIT surgery or emergency thoracotomy is a reliable strategy depending on the medical resources available.
Feature Selection of Surface Topography Parameters for Fatigue Damage Detection Using...
HASSAN ALQAHTANI
Asok Ray

HASSAN ALQAHTANI

and 1 more

September 16, 2022
The global objective of this study was to investigate the best features of the surface topography for fatigue damage detection and classification. The presence of the stress concentration in valleys of the surface topography causes a grain slip and a crack initiation at the surface of the machined structure and finally leads to fatigue failures. Therefore, the surface topography has a major influence on the fatigue strength of the machined structure. An optical confocal measurement system (Alicona) was applied to measure the surface topography parameters. These parameters are the arithmetical mean height S a , the root-mean-square height S q , the maximum peak height S p , the maximum valley depth S v , the maximum height S z , and ten-points height S z 1 0 . In this paper, feature selection using the Pearson correlation method was adopted to select the best surface textures that provide best the neural network (NN) model performance.The proposed NN models have been trained using the scaled conjugate-gradient back-propagation method. Results showed that the best surface topography parameters were S a , S v , S 1 0 Z , S z , where the NN model can detect and classify the damage with an accuracy of up to ∼94 .4%.
CMMSE: POWERS OF CATALAN GENERATING FUNCTIONS FOR BOUNDED OPERATORS
Pedro José Miana Sanz
Natalia Romero

Pedro José Miana Sanz

and 1 more

September 16, 2022
In this paper we consider the Catalan triangle numbers ( B n , k ) n ≥ 1 , 1 ≤ k ≤ n and ( A n , k ) n ≥ 1 , 1 ≤ k ≤ n + 1 to define powers of Catalan generating function C( T) where T is a linear and bounded operator on a Banach space X. When the operator 4 T is of power-bounded operator, the Catalan generating function is given by the Taylor series C ( T ) : = ∑ n = 0 ∞ C n T n , where c = ( C n ) n ≥ 0 is the Catalan sequence. Note that the operator C( T) is a solution of the quadratic equation T Y 2 − Y + I = 0 . We obtain new formulae which involves Catalan triangle numbers ( B n , k ) n ≥ 1 , 1 ≤ k ≤ n and ( A n , k ) n ≥ 1 , 1 ≤ k ≤ n + 1 . As element in the Banach algebra ℓ 1 ( N 0 , 1 4 n ) , we describe the spectrum of c ∗ j for j≥1, and the expression of c −∗ j in terms of Catalan polynomials. In the last section, we give some particular examples to illustrate our results and some ideas to continue this research in the future.
Syncope: an uncommon Pulmonary Embolism presentation in COVID infection with low Well...
Eric Gehres
Zeinab Abdulraham

Eric Gehres

and 3 more

September 16, 2022
Pulmonary Embolism has been well established to be a potential life threatening medical emergency. Patients typically present with pleuritic chest pain with pressure, tachycardia, tachypnea, and desaturation of oxygen levels. We describe a case in which a COVID positive male presented to the ED via ambulance with saddle PE.
Letter to the Editor: Early experience of aortic surgery during the COVID-19 pandemic...
Sara Alzaglool
Osama Al-Jaiuossi

Sara Alzaglool

and 1 more

September 16, 2022
TITLE PAGE Title: Letter to the Editor: Early experience of aortic surgery during the COVID-19 pandemic in the United Kingdom: A multicenter studyArticle type: Letter to the editorCorrespondence : 1. Sara AlzagloolContact: +962797244907 Email: Sarah97.zg@hotmail.comInstitute: Al-Bashir HospitalAddress: Al Bashir Hospital، Ossamah Ben Zeid St. 261, Amman, JordanCo-authors : 2. Osama Al-JaiuossiContact: +962788003306 Email: Osamaeyad@ymail.comInstitute: Al-Bashir HospitalAddress: Al Bashir Hospital، Ossamah Ben Zeid St. 261, Amman, JordanWords count: 480Conflict of interest: NoneFunding: NoneAcknowledgement: NoneDeclaration: None
Infected Chylopericardium: An Unexpected Cause of Cardiac Tamponade
Renzo Cifuentes
Diego Celli

Renzo Cifuentes

and 5 more

September 16, 2022
A 22-year-old immunocompetent female with a history of small pericardial effusion while infant presented with fever and hemodynamic collapse four days after facial trauma. She was found to have cardiac tamponade secondary to infected chylopericardium from bacterial translocation. We report this very unusual case and review of the literature on chylopericardium infections.
Antiplatelet Resistance in Coronary Artery Bypass Grafting: A Systematic Review
Myat Thet
Amir Khosravi

Myat Thet

and 3 more

September 16, 2022
Introduction: Aspirin and clopidogrel are the most commonly used antiplatelet agents, either alone or as dual therapy, in patients undergoing CABG surgery to reduce organ ischaemia and mortality. The systematic review aims to explore the resistance to the antiplatelet agents, how to assess it, and the effect of resistance on the outcomes in CABG surgery. Materials & methods: A systematic search is carried out on MEDLINE via Ovid, PubMed, Embase, the Cochrane Library Database and Google Scholar until November 2021 to look for studies evaluating the antiplatelet resistance in patients undergoing both on-pump and off-pump CABG surgery. Only high-quality studies were included after the risk of bias assessment. Results: A total of 17 studies, of which 3 randomised controlled trials and 14 observational studies were included after inclusion criteria is applied. The incidence of aspirin resistance ranges from 11-51.5%, whereas, clopidogrel resistance is 22%. A wide variety of different assessment methods for antiplatelets are reported. Antiplatelet resistance is a predictor of vein graft occlusion, with up to 13 fold increase in occlusion rate. There is no overall effect of aspirin resistance on mortality, stroke or myocardial infarction, however, clopidogrel resistance leads to higher mortality, MI and target vessel revascularisations. The effect of cardiopulmonary bypass on antiplatelet resistance is not clear. Conclusion: There is no uniform definition of antiplatelet resistance. Assessment methods differ greatly and their results are not interchangeable. Antiplatelet resistance is associated with a higher rate of graft occlusion in CABG patients. Aspirin resistance does not influence overall adverse outcomes, however, clopidogrel resistance leads to worse outcomes.
A Quantitative Analysis of Wide-Area Phasor Measurement Unit Data
Travis Hagan
Eduardo Cotilla-Sanchez

Travis Hagan

and 4 more

September 16, 2022
This paper contributes to the growing body of work that aims to characterize similarities and differences between synchrophasor data from real-power systems and those from synthetic power systems with emulated Phasor Measurement Units (PMUs). In particular, we survey previous works that characterize PMU noise and analyze the impacts on applications of these time-series data into machine learning algorithms in the power systems domain. We benchmark these methodologies with three datasets: data from an Oregon State University local PMU network, from two PMUs using the same set of sensors, and from multiple-utility interconnect-wide data. We found that it is important to consider each signal individually when synthesizing PMU data with noise, and that the noise needs to be adjusted by key statistical metrics.
INVERSE PROBLEMS FOR A BOUSSINESQ SYSTEM FOR INCOMPRESSIBLE VISCOELASTIC FLUIDS
Khonatbek Khompysh
Stanislav Antontsev

Khonatbek Khompysh

and 1 more

September 15, 2022
In this paper, we study two inverse problems for the nonlinear Boussinesq system for incompressible viscoelastic non-isothermal Kelvin-Voigt fluids. The studying inverse problems consist of determining an intensities of density of external forces and heat source under given integral overdetermination conditions. Two types of boundary conditions for the velocity v are considered: sticking and sliding conditions on boundary. In both cases of these boundary conditions, the local and global in time existence and uniqueness of weak and strong solutions are established under suitable assumptions on the data. The large time behavior of weak solutions is also studied.
Assorted optical solitons of the cubic and cubic quintic nonlinear Schrödinger equati...
Ahmet Bekir
Md. Morshedul Haque

Ahmet Bekir

and 3 more

September 15, 2022
Although fractional and classical order cubic quintic nonlinear Schrödinger (NS) equation and cubic nonlinear Schrödinger equation are used simultaneously in nonlinear optics disciplines, the fractional-order NS equations are nowadays extensively used due to their higher coherence. The space-time fractional cubic quintic and nonlinear cubic Schrödinger equations integrating beta derivative are significant in modeling to nonlinear optics, photonics, plasmas, condensed matter physics, and other domains. The fractional wave transformation is exploited to translate the space-time fractional equations and the optical soliton solutions in the form of exponential, trigonometric, and hyperbolic functions with free parameters have been established in this article by putting to use the improved Bernoulli sub-equation function (IBSEF) approach. The shape of the solutions includes kink, periodic, bell-shaped soliton, breathing soliton, bright soliton, and singular kink type soliton. The physical features of the solitons have been revealed by depicting 3D, 2D, contour, and density graphs of some of the solutions. The results demonstrate that the IBSEF approach is simple, straightforward, effective and that it can be applied to a wide range of nonlinear fractional-order models in optics and communication engineering to achieve soliton solutions.
Conserved transcriptional programming across sex and species after peripheral nerve i...
Shahrzad Ghazisaeidi
Milind Muley

Shahrzad Ghazisaeidi

and 7 more

September 15, 2022
Background and Purpose: Chronic pain is a devastating problem affecting 1 in 5 individuals around the globe, with neuropathic pain the most debilitating and poorly treated type of chronic pain. Advances in transcriptomics and data mining have contributed to cataloging diverse cellular pathways and transcriptomic alterations in response to peripheral nerve injury but have focused on phenomenology and classifying transcriptomic responses. Experimental approach: Here, with the goal of identifying new types of pain-relieving agents, we compared transcriptional reprogramming changes in the dorsal spinal cord after peripheral nerve injury cross-sex and cross-species and imputed commonalities, as well as differences in cellular pathways and gene regulation. Key Results: We identified 93 transcripts in the dorsal horn that were increased by peripheral nerve injury in male and female mice and rats. Following gene ontology and transcription factor analyses, we constructed a pain interactome for the proteins encoded by the differentially expressed genes, discovering new, conserved signaling nodes. We interrogated the interactome with the Drug-Gene database to predict FDA-approved medications that may modulate key nodes within the network. The top hit from the analysis was fostamatinib, the molecular target of which is the non-receptor tyrosine kinase Syk, which our analysis had identified as a key node in the interactome. Conclusions & Implications : We found that intrathecally administrating the active metabolite of fostamatinib, R406, significantly reversed pain hypersensitivity in both sexes. Thus, we have identified and shown the efficacy of an agent that could not have been previously predicted to have analgesic properties.
SARS-CoV-2-Triggered Hemophagocytic Lymphohistiocytosis with Complications of Posteri...
Ross M. Perry
Scott D. Casey

Ross M. Perry

and 6 more

August 24, 2022
SARS-CoV-2-Triggered Hemophagocytic Lymphohistiocytosis with Complications of Posterior Reversible Encephalopathy SyndromeRoss M. Perry, M.D. a* | Scott D. Casey, M.D., M.S. b | Alex Q. Lee, M.D.a | Sylvia P. Bowditch, M.D.c | Mary A. Rasmussen, M.D.c | Viyeka Sethi, M.D. d| Arun R. Panigrahi, M.D. eaUniversity of California, Davis, School of Medicine, Sacramento, California, USA; bDepartment of Emergency Medicine, University of California, Davis, Sacramento, California, U.S.A.; cDepartment of Pediatrics, University of California, Davis, Sacramento, California, U.S.A;dDepartment of Pediatric Critical Care Medicine, University of California, Davis, Sacramento, California, U.S.A;eDepartment of Pediatric Hematology & Oncology, University of California, Davis, Sacramento, California, U.S.A*Correspondence to:Ross Perry, M.D., 14 Rock Lane, Berkeley, CA, 94708, Phone: (707) 331-4626, Fax: (510) 752-1571, E-mail: rossmperry@gmail.comMain Text Word Count: 850Tables: 1; Figures: 1Short Title: SARS-CoV-2-Triggered HLH Complicated by PRESKeywords: SARS-CoV-2, HLH, PRES, MIS-C, corticosteroids, anakinra
Target enrichment of long open reading frames and ultraconserved elements to link mic...
Claudia Ortiz-Sepulveda
Mathieu Genete

Claudia Ortiz-Sepulveda

and 6 more

December 01, 2021
Despite the increasing accessibility of high-throughput sequencing, obtaining high-quality genomic data on non-model organisms without proximate well-assembled and annotated genomes remains challenging. Here we describe a workflow that takes advantage of distant genomic resources and ingroup transcriptomes to select and jointly enrich long open reading frames (ORFs) and ultraconserved elements (UCEs) from genomic samples for integrative studies of microevolutionary and macroevolutionary dynamics. This workflow is applied to samples of the African unionid bivalve tribe Coelaturini (Parreysiinae) at basin and continent-wide scales. Our results indicate that ORFs are efficiently captured without prior identification of intron-exon boundaries. The enrichment of UCEs was less successful, but nevertheless produced substantial datasets. Exploratory continent-wide phylogenetic analyses with ORF supercontigs (>515,000 parsimony informative sites) resulted in a fully resolved phylogeny, the backbone of which was also retrieved with UCEs (>11,000 informative sites). Variant calling on ORFs and UCEs of Coelaturini from the Malawi Basin produced ~2,000 SNPs per population pair. Estimates of nucleotide diversity and population differentiation were similar for ORFs and UCEs. They were low compared to previous estimates in mollusks, but comparable to those in recently diversifying Malawi cichlids and other taxa at an early stage of speciation. Skimming off-target sequence data from the same enriched libraries of Coelaturini from the Malawi Basin, we reconstructed the maternally-inherited mitogenome, which displays the gene order inferred for the most recent common ancestor of Unionidae. Overall, our workflow and results provide exciting perspectives for integrative genomic studies of microevolutionary and macroevolutionary dynamics in non-model organisms.
The original music  artists and their music I love - The Beatles            
Yiren Qin

Yiren Qin

September 16, 2022
The original music artists and their music I love - The BeatlesYiren Qin1,*1Black Family Stem Cell Institute, Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.*Correspondence address: yiren.qin@mssm.edu           If one day YouTube can’t be used, the most painful thing may be that I can no longer enjoy my favorite original music and its videos I love. When my work is not going well, it makes me irritable, dull and even pessimistic and disappointed from time to time. However, it is the original music that allows me quickly alleviate from this unhappiness and gives me the motivation and courage to continue working hard. It is the original music that makes me feel the charm of the art more deeply and lets me get more inspiration and enlightenment to do scientific research. Here, I’d like to write down the original music artists and their music I love and share them with my readers.           First, let me introduce my favorite rock band - The Beatles.        Speaking of the Beatles, we will think of John Lennon, Paul McCartney, George Harrison and Ringo Starr (Richard Starkey) from Liverpool, England. From their 20-year-old debut to conquest of the world, to the disbandment of the band that had been working for less than ten years, to the early death of Lennon at 40 and Harrison at 58, as a complete fan of the Beatles, my heart is filled with sadness. Only when I see them still singing in the video, do I feel that the Beatles are always there and live young forever in my heart.      As a band in the 1960s, most Chinese people probably only heard about it literally, and seldom listened, felt and understood the Beatles’ songs. There are 188 original songs created by the Beatles [1], most of which were created by the core of the band Lennon and McCartney individually or together (The creation here means writing lyrics and composing music), and the public contributions are marked with Lennon-McCartney. In addition, lead guitarist Harrison created 25 songs and drummer Starr created 2 songs. There are 78 my favorite songs of the Beatles. Whenever I walk to the supermarket and wait in a long line, whenever I am thinking quietly in the middle of the night, whenever I feel down, I play these 78 songs in a continuous loop on YouTube and listen to them ecstatically. Here, I introduce representative songs of the Beatles, the achievements and honors of the Beatles and its members, and the development of each member after the disbandment of the band.    1. Representative songs of the Beatles    1.1. Love songs in the early stage of the band     Just as Jeannette Catsoulis, a reporter from The New York Times, described her personal experience when she participated in the Beatles concert in 1964 in an article published in this newspaper in 2015: “I think I had my first orgasm at a Beatles concert - then again, how would I have known? When you’re preteen, prepubescent and pretty much pre-everything, ‘I want to hold your hand’ seems the height of erotic ambition. And that was especially true in 1964, before the sexual revolution and the Internet made that kind of ignorance unimaginable” [2].     1.1.1 “I want to hold your hand”     This is a love song created and sung by Lennon and McCartney together in 1963 that can ignite youth hormones. It sounds tight-paced and canty, cheerful and euphonic, amazing and passionate. It is also a perfect tune played in harmony with Harrison and Lennon’s guitar, McCartney’s bass and Starr’s drumming, and has become the best-selling single of the Beatles in the world [3]. This song is ranked 16th on the Rolling Stone’s 500 greatest songs of all time [4].     1.1.2 “She loves you”       This is an unusual love song created and vocalized by Lennon and McCartney in 1963, and harmonically vocalized by Harrison. As a lovesickness song, the melody sounds musical and euphonic, but with a little miss and concern. In addition, what is unusual about this song is that the lyrics are not about the writer's love for the person he likes, but as an intermediary to describe a love that is impossible to be together, as described in the lyrics:              “You think you lost your love,       Well, I saw her yesterday.      It's you she's thinking of       And she told me what to say.      She says she loves you ...      You hurt her      She didn't know why      It wasn't your fault      And didn't turn around      Oh yes she loves you      Because with you alone she can only be happy...”      This song was the highest-selling single of the Beatles in the UK. It also was the highest-selling single among all artists in the 1960s [5]. Rolling Stones ranked it 64th on the 500 greatest songs of all time [4].       1.1.3 “I should have known better”      This love song was created by Lennon alone in 1964 and sung by Lennon and McCartney together. It sounds very dulcet, euphonic, joyful and pleasant. Harrison's superb guitar chords make the tune of this song even more sublime. In a live video of the Beatles that I like most to watch, all four of them perform extremely cheerfully. In addition to playing the guitar, Lennon also plays the harmonica interspersed. McCartney squints Lennon from time to time to keep up with his rhythm. Harrison dances happily while playing his guitar. Starr can’t close his mouth gladly. What's interesting is that at the end of this video, a fan admires the performance of the Beatles with ecstasy. When he finally raises his hand to cheer, he finds himself in handcuffs with another cheering person. This is the state of the Beatles fanaticism.     1.1.4 “And I love her”       This is a very sweet love song created and sung by McCartney alone in 1964. McCartney's beautiful singing voice combined with slow guitar and soft drum accompaniment sounds very pleasant and melodious. McCartney called it the first lyrical song to impress him [6]      1.1.5 “When I am sixty-four”        This is a song created by McCartney at the age of about 16 and released in 1967 [7]. It describes the young guy hoping to be with the person he loves and grow old. The song is sung by McCartney alone, and the melody sounds soothing, euphonic and musical. Incorporating Starr's harmonious and powerful drumming, it also sounds a touch of sadness and concern. I like listening to this song very much, but I also think that the two members of the Beatles did not live to 64 years old, so I feel a trifle sad.     1.1.6 “Yesterday”     This is a slightly sentimental love song created by McCartney in 1965. It’s sung by McCartney alone by playing the guitar. It’s also the first solo song performed by the Beatles. The melody sounds simple, dulcet and melodious. It is still popular today. There are more than 2,200 cover versions of this song and it is considered to be the most covered song in the recorded music history [8]. This song was voted as the best song of the 20th century in the BBC radio poll in 1999 [8]. It was ranked 13th in the Rolling Stone’s 500 greatest songs of all time [4]. According to the biographers of McCartney and the Beatle, this song was conceived by McCartney when he was dreaming of the entire melody. He played it in front of the piano immediately after he woke up so as not to forget [8]. The same is true when I write articles. I often dream of new ideas when I sleep. I take notes immediately after I wake up.         1.2 Representative songs created and sung by Harrison during the band      Harrison was the youngest in the band (3 years younger than Lennon and Starr, and 1 year younger than McCartney). His music creation and singing talents during the Beatles were mostly overshadowed by the geniuses of Lennon and McCartney, so he said he was an "invisible" singer in the band. Here, I introduce the two most famous songs he created when he was in the band, "While my guitar gently weeps" and "Something". Both of them entered the Rolling Stone’s 500 greatest songs of all time, ranking 136th and 278th respectively [4], and both of them entered Rolling Stone’s top 10 songs of the Beatles of all time [9].      1.2.1 “While my guitar gently weeps”     This song was inspired by the Chinese I Ching. When Harrison went to his parents’ home, saw the book for the first time and he finished reading it, he found that the Eastern culture he had felt was the opposite of what was introduced in the West [10], as described in the lyrics:       “...I look at the floor and I see it needs sweeping       Still my guitar gently weeps.       I don't know why nobody told you       How to unfold your love        I don't know how someone controlled you        They bought and sold you...        With every mistake we must surely be learning        Still my guitar gently weeps        I don't know how you were diverted        You were perverted too        I don't know how you were inverted.”       This song conveys Harrison’s disappointment that there is unrealized potential for universal love in this world, just as he said "The love there that's sleeping". The melody of the song sounds incredibly euphonic, beckoning and melodious at the same time with a hint of disappointment and sentimentality. It is one of my favorite songs of the Beatles. In addition, this song was ranked 7th among the Rolling stone’s 100 greatest guitar songs of all times [11].         1.2.2 “Something”        Some music historians believed that this song reflected that Harrison's music creation level could catch up with Lennon and McCartney [12]. When this song was composed, Harrison and Pattie, Lennon and Yoko, McCartney and Linda, Starr and Maureen were all in the love of the duo. The melody of the song sounds sweet, dulcet, euphonic and comfortable, which is very suitable for men and women in love. This song has been covered by more than 150 artists and is the second most covered song of the Beatles after "Yesterday". It is ranked 17th among the most covered songs of the 20th century listed by Broadcast Music Incorporated. In addition, the song was named the best songwriting and composition song of 1969 by the Ivor Novello Award [12].        1.3 The song created and vocalized by Starr during the band - “Octopus’s Garden”         This song sounds very peaceful and easy, also musical and joyful. Harrison, who helped Starr complete the song, commented on the song: "This cosmic song is lovely and so peaceful" [13], as the lyrics mention:       “I'd like to be        Under the sea        In an octopus' garden        In the shade...        Oh what joy        For every girl and boy        Knowing they're happy        And they're safe...”        Besides, due to the peaceful and cheerful rhyming of lyrics and music, it is sometimes regarded as a children's song [13].       1.4 Sad songs in the band's later stage       In the later stage of the Beatles, McCartney became the actual leader of the band, and he created and sang most of the songs. Because the band was facing disbandment, some songs created in this period sounded sad. Here I list the 3 most representative songs:        1.4.1 “Hey Jude”        This is an almost household song of the Beatles, created and sung by McCartney alone in 1968. The creative inspiration came from the radical changes caused by the band's later disbandment. It was also at this time that Lennon left his wife Cynthia and his 5-year-old son Julian for Yoko. During this period, McCartney drove to visit Cynthia and Julian, and wrote this song on the way back. It was originally called "Hey Jules" and later changed to "Hey Jude". This song was to comfort Julian from the pressure of separation from his parents [14]. As the lyrics describe:       “Hey Jude, don't make it bad.        Take a sad song and make it better.         Remember to let her into your heart,        Then you can start to make it better.        Hey Jude, don't be afraid.        You were made to go out and get her.        The minute you let her under your skin,        Then you begin to make it better.         And anytime you feel the pain, hey Jude, refrain,         Don't carry the world upon your shoulders.         For well you know that it's a fool who plays it cool         By making his world a little colder...”         This song sounds sort of sad, yet soothing and euphonic. The simple and beautiful melody fully embodies McCartney's genius for music creation. This song is the highest-ranked single of the Beatles, ranking 8th among the Rolling Stone’s 500 greatest songs of all time [4]. At the opening ceremony of the 2012 London Olympics, 70-year-old McCartney was still passionate about playing and performing this song in front of the piano. Singing with everyone present, he walked to the big stage to wave his hands and interact with the audience, which brought the atmosphere on the scene to a climax.       1.4.2 “The long and winding road”      This song was created and sung solely by McCartney in 1968 and released publicly in 1970. The creative intention came from the growing tension between the band members. The melody of the song sounds very sad and moving, making people cry. In a live video in the studio of the Beatles, McCartney sat in front of the piano practicing the song. He looked a bit decadent with a long beard while Lennon and Yoko sat on the carpet together smoking cigarettes and flirting. This was the scene in the late stage of the Beatles.       1.4.3 Let it be        The creative inspiration of this song was the same as the above "The long and winding road". Faced with the possible disbandment of the band in the future, McCartney was very sad and disappointed. At this time, he often thought of his mother who left him when he was 14 years old. Once in a dream, his mother Mary told him: "It will be all right, just let it be", so he named this song "Let it be" [15], as the lyrics describe:     “When I find myself in times of trouble, Mother Mary comes to me      Speaking words of wisdom, let it be      And in my hour of darkness she is standing right in front of me      Speaking words of wisdom, let it be      Let it be, let it be, let it be, let it be      Whisper words of wisdom, let it be      And when the broken hearted people living in the world agree      There will be an answer, let it be      For though they may be parted, there is still a chance that they will see      There will be an answer, let it be...”      In this song, McCartney’s excellent singing voice and his beautiful piano performance, Harrison and Lennon’s melodious and harmonious guitar ensemble, and Starr’s sonorous and powerful drum accompaniment, make the whole melody perfect. This song was the last single of the Beatles before McCartney announced his departure from the band. It is also one of the most well-known songs of the Beatles. Rolling Stones ranked it 20th in the 500 greatest songs of all time [4].         1.5 Some other songs     In addition to the above songs, I’d like to recommend some little-known and wonderful songs from the Beatles:      Fast-paced and cheerful songs: "Thank you girl" (Created by Lennon and Paul McCartney and dedicated to female fans as a gift. Drumming-based accompaniment brings Starr’s percussion wisdom to the extreme.), "Hold me tight", "Ob-La-Di, Ob-La-Da", "Drive my car", "Birthday";      Soothing and melodious songs: “Free as birds” (Created by Lennon in 1977 after the disbanding of the band, and recorded by the Beatles members together again), “Golden slumber”, “Carry that weigh”, “We can work out”, “Black bird”, “Two of us”, “Do you want a secret”, “Wait”, “Here, there and everywhere”, “Yes it is”;       Harmonious and moving songs: "This boy" (A perfect and harmonious tune vocalized by Lennon, McCarney, and Harrison at the same time);       Kind of sad, yet affecting songs: “Girl”, “Don’t let me down” (A anguished love song created by Lennon for Yoko);        Touching and beautiful songs: “Things we said today”, “Ask my why”;       The first non-love song of the Beatles: “Nowhere man”.       1.6 The Beatles vs Mozart       Some people might laugh at me: "In the new era, you actually even introduce us to the old-fashioned songs that grandpas listened to". The following is my defense:       First of all, in the 1960s in China, our grandpa’s generation had never heard of rock music in their youth, nor had they had the opportunity to listen to and understand the Beatles’ songs.           Secondly, according to data from Spotify, the world's largest music media streaming provider, the Beatles' songs were played 1.7 billion times in 2019, and 30% of the listeners were 18 to 24 years old [16]. It suggested that “the Beatles remain a popular culture phenomenon even among Gen Z fans” [16].       Thirdly, Mozart’s music is more than two hundred years old. Why not only does no one say that it is old-fashioned, but it is hailed as a classic and elegant art and played in the extravagant music hall for non-ordinary people to appreciate? In comparison, is the popular music of the Beatles vulgar than the classical music of Mozart? As far as art itself is concerned, as sad music, Mozart's "Symphony No.40" is more objectively superior to the Beatles' "Let it be"? NO! In an article entitled "Mozart vs the Beatles" published by American philosopher Gary Gutting in The New York Time in 2013, he commented: “…the alleged superiority of high culture has often supported the pretensions of an aristocratic class claiming to have privileged access to it … The Beatles, attracted people for their catchy melodies, teasing lyrics, cool attitudes, sense of musical adventure, political views, and by now even the memories they evoke … The same can be true of works of high art” [17]. Interestingly, Gutting's article is also accompanied by a satirical cartoon. It describes a pianist stepping onto the stage, picking up Mozart's sheet music, and playing intoxicatingly. But the close-up of a male and female listeners scratch their heads and can't understand the music. After the pianist finish playing, he goes back to his car with flowers, and then play Britney Spears' CD and drive away with headphones. I think that in a society where the hereditary aristocracy has been eliminated, even billionaire entrepreneurs would not listen to dull and tedious classical music every day, but would enjoy free and individual popular music at every moment of their leisure.            Last, among the Rolling Stone’s 500 greatest songs of all time in 2010, 39.2% were from the 1960s, 26.2% from the 1970s, 11% from the 1980s, 4.4% from the 1990s, 5.4% from the 2000s [4]. These data fully suggest that the appreciation value and artistic level of modern popular music are demonstrating a clear downward trend. I personally think that in the era of artificial intelligence, the artistic wisdom and creativity of human beings may have also declined.       2. The achievements and honors of the Beatles and its members       2.1 The rise of the Beatles ended the era of American non-original singer Elvis Presley, and achieved the Beatles era that conquered the world, and made the British music invade the United States, the birthplace of rock music.        2.2 The Beatles are by far the highest-selling music artists [18]. In addition, in the 1960s, the British economy was in a crisis of depletion of the U.S. dollar and could not maintain its commitment to fix the exchange rate at 2.8 U.S. dollars per pound. The savior of this crisis was the Beatles, and it was the money the Beatles made from touring the United States and other countries that turned the tide [19]. According to media statistics, the Beatles made $650 per second from 1964 to 1966 [19]. Nearly half a century after the disbandment of the Beatles, the four members earned 71 million U.S. dollars in 2013 [20], earning $2.25 per second.      2.3 Among the 500 greatest songs listed by Rolling Stones in 2004/2010, the artist with the most selected songs were the Beatles, contributing 23 songs, of which 10 are in the top 100 [4].       2.4 The famous media's evaluation of the Beatles      2.4.1 Among the 100 greatest artists of all time from Rolling Stone, the Beatle ranked first [21].      2.4.2 Among the 100 most successful artists listed by Billboard in 2008, the Beatles ranked first [22];      2.4.3 Among the 100 most influential people of the 20th century collected by Times, the Beatles was listed [23].      2.5 Famous media’s evaluation of the members of the Beatles:      2.5.1 Among the 100 greatest British people named by the BBC in 2002, Lennon and McCartney ranked 8th and 19th respectively. Only two scientists ranked above them, Charles Darwin and Isaac Newton. Harrison ranked 62nd, surpassing steam engine inventor James Watt and comedian Charlie Chaplin [24].        2.5.2 Among the 100 greatest songwriters of all time from Rolling Stones, McCartney ranked second, Lennon ranked third, and Harrison ranked 65th [25].       2.5.3 Among the 100 greatest singer of all time from Rolling Stones, Lennon ranked 5th and McCartney ranked 19th [26].       2.5.4 Among the 100 greatest guitarists of all time from Rolling Stones, Harrison ranked 11th and Lennon ranked 55th [27]. Lennon was not only a genius of music creation and singing, but he was also an outstanding guitarist, which is less known, so Lennon said that he was the "invisible" guitarist in the band.        2.5.5 Among the 100 greatest drummers of all time from Rolling Stones, Starr ranked 14th [28]. Although Starr is not the drummer with the best percussion skills among the rock bands, he can play the most perfect rock music with other members of the Beatles. Some people call him the godfather of rock percussion, because his art of playing percussion with his own sense and wisdom has taught other drummers with better skills a vivid lesson: Drumming is not only a violent beating with your hands, but more importantly, using your brain.      3. The development of each member after the disbandment of the band       After the Beatles was disbanded, the four members independently developed their own music careers.            As a peace activist and philosophical artist, Lennon created the astounding masterpiece - "Imaging". Rolling Stones described this song as Lennon's greatest musical work dedicated to the world [29]. The song’s calm and clear melody, and soft chord progress make it perfect. It is ranked No. 3 on the Rolling Stone’s the 500 greatest songs [4]. At the closing ceremony of the 2012 London Olympics, a video of Lennon playing and singing the song in front of the piano was shown on the giant screen.       “Imagine there's no heaven        It's easy if you try        No hell below us        Above us, only sky        Imagine all the people        Livin' for today        Ah...”        It seems that Lennon “Get back” (a famous song created by McCartney at the late stage of the Beatles).        McCartney has been very depressed and sad for a while after the band just disbanded, so he composed the famous song "Maybe I'm Amazed" to express his mood at that time, as the lyrics describe:       “Maybe I'm amazed at what's going on ...         Maybe I'm a man and maybe you're the only woman who could ever help me;         Baby won't you help me understand ...         Maybe I'm amazed at the way you pulled me out of time, hung me on the line,         Maybe I'm amazed at the way I really need you."        Later, McCartney and his wife Linda and other members formed the Wings, which became one of the most successful bands in the 1970s [30]. In addition, McCartney is also one of the richest musicians in the world, with an estimated wealth of 800 million pounds as of 2020 [31]. During the COVID-19 outbreak in 2020, famous singers from all over the world participated in a live online global concert with the theme "One World: Together At Home" to thank and encourage the medical staff who are fighting on the front lines. 78-year-old McCartney was invited to participate in the performance. He looked still vigorous and sang the famous song "Lady Madonna" that he created during the Beatles period while playing the piano.       Harrison independently developed his own music career after the band was disbanded, and has also made brilliant achievements. He created many very beautiful and high-selling songs, the most famous such as "My sweet lord", which became the No.1 single in the international rankings at the end of 1970 and early 1971 [32]. Harrison was also a very wealthy musician, with a fortune of 100 million pounds during his lifetime [33].        After the band was disbanded, Starr’s music career also flourishes. He becomes the richest drummer in the world, with an estimated wealth of 350 million pounds as of 2020 [34].        The brief introduction of the Beatles is over, but listening to the Beatles' music is endless.                 This article is dedicated to my beloved the Beatles!        Yiren Qin         Nov. 2021, Manhattan, New YorkReferences[1] List of songs recorded by the Beatles, Wikipedia[2] Jeannette Catsouli, The Beatles Awaken a New Sensation. The New York Times, 2015.  [3] I Want to Hold Your Hand, Wikipedia[4] 500 Greatest Songs of All Time, Rolling Stone[5] She Loves You, Wikipedia[6] And I Love Her, Wikipedia[7] Paul McCartney: The Lyrics: 1956 to the Present, Publisher: ‎ Liveright (November 2, 2021), ISBN-10: ‎ 163149256X, p791.[8] Yesterday (Beatles song), Wikipedia[9] The Top Ten Beatles Songs of All Time, Rolling Stone[10] While My Guitar Gently Weeps, Wikipedia  [11] Rolling Stone‘s 100 Greatest Guitar Songs Of All Time[12] Something (Beatles song), Wikipedia[13] Octopus’s Garden, Wikipedia[14] Hey Jude, Wikipedia[15] Let It Be (Beatles song), Wikipedia[16] UCR CLASSIC ROCK & CULTURE: Thirty Percent of Spotify Beatles Streams Are by 18-24-Year-Olds[17] Gary Gutting, Mozart vs. the Beatles, The New York Times, 2013[18] List of best-selling music artists, Wikipedia[19] Kristin Forbes, Financial “deglobalization”?: capital flows, banks, and the Beatles[20] How The Beatles Earned $71 Million This Year, Sort Of, Forbes[21] 100 Greatest Artists, Rolling Stone[22] Hot 100 All-Time Top Artists, The Billboard[23] The Beatles- Irrepressible and irresistible, they were — and remain — the world's most astonishing rock-'n'-roll band, Times[24] 100 Greatest Britons, Wikipedia[25] 100 Greatest Songwriters of All Time, Rolling Stone[26] 100 Greatest Singers of All Time, Rolling Stone[27] 100 Greatest Guitarists, Rolling Stone[28] 100 Greatest Drummers of All Time, Rolling Stone[29] Imagine (John Lennon song), Wikipedia[30] Paul McCartney and Wings, Wikipedia[31] Paul McCartney, Wikipedia[32] My Sweet Lord, Wikipedia[33] George Harrison, Wikipedia[34] Ringo Starr, Wikipedia        
Successful treatment with ivabradine in a β-blocker refractory patient with acute dec...
Tomoko Inoue
Keiji Matsunaga

Tomoko Inoue

and 3 more

September 15, 2022
Ivabradine is an established treatment for chronic heart failure with reduced ejection fraction (HFrEF) but not for acute heart failure. β-blocker up-titration is often not possible because of its negative inotropic effect (NIE). Ivabradine has no NIE; therefore, it may be preferred over β-blockers in patients with acute decompensated HFrEF.
3D organization of chicken genome demonstrates evolutionary conservation to extreme e...
Dan Shao
Yu Yang

Dan Shao

and 3 more

September 15, 2022
High-through chromosome conformation capture (Hi-C) technique is widely used to study the functional roles of the three-dimensional (3D) genome architecture of genomes. However, knowledge of 3D genome structure and its dynamic during extreme environments adaption remain poor. Here we characterized 3D genome architectures with Hi-C technique for chicken liver cells. By comparing Lindian chicken (LDC) liver cells with Wenchang chicken (WCC) liver cells, we discovered that environmental adaption contributed to the switching of A/B compartments, the reorganization of topologically associated domains (TADs) and TAD boundaries in both liver cells. Besides, analysis of the switching of A/B compartments combined with liver transcriptome revealed the corresponding changes of gene expression were strongly associated with extreme environment adaption-related pathways, including Tight junction, Notch signaling pathway, Vascular smooth muscle contraction, RIG-I-like receptor signaling pathway and Glycosphingolipid biosynthesis pathways. This study advanced our understanding of evolutionary role of chicken 3D genome architecture and their significance in genome activity and transcriptional regulation.
Commentary on the European Medicines Agency's extended mandate - Protecting public he...
Inga Abed
Rosa Gonzalez-Quevedo

Inga Abed

and 5 more

September 15, 2022
The European Medicines Agency (EMA) started operating under its new legal mandate on 1 April 2022. The mandate brings new responsibilities to the Agency in three different areas: • Reinforcement of the role and activities of the EMA pandemic Task Force(which is now known as the Emergency Task Force (ETF)). • A stronger role of EMA in the monitoring of shortages of critical medicines, medical devices and in-vitro diagnostics, both in anticipation of and during a crisis. • A more coordinated mechanism of European Union (EU) experts advice on medical devices classified as high-risk (class IIa and III or class D (1)) and in-vitro diagnostic medical devices. Here we consider the impact of the COVID-19 pandemic on the operations of EMA and the European medicines regulatory network, and how EMA’s new mandate will strengthen the Agency’s and the Network’s ability to face crises. EMA’s extended mandate brings clear benefits in terms of response to public health emergencies at EU level, which ranges from improvements in crisis management to avoiding medicine shortages and improving access to diagnostics and medical devices that are safe and conform to their expected function.
The beneficial effects of pomegranate (Punica granatum L.) consumption on human healt...
Agnese Di Napoli

Agnese Di Napoli

and 3 more

October 10, 2022
The pomegranate (Punica granatum L.) is a small tree or shrub, which is grown in large parts of the world. The medicinal properties of this plant are known since ancient times and are due to the phytochemical constituents found in the plant. This review describes the therapeutic effects of pomegranate, which are reported in the scientific literature. We performed a literature search, using the PubMed database. We utilised this database to find the research articles published between 2000 and 2021, showing the medicinal properties of oral intake of pomegranate. We included 55 research articles and we found 11 beneficial effects of pomegranate consumption on human health. The therapeutic effects of this plant comprise those on diabetes, the cardiovascular system, oxidative status, the nervous system, cancer, colitis, metabolic syndrome and obesity, arthritis, the reproductive system, parasitic infections and skin health. Cardiovascular, antioxidant and antidiabetic activities are well reported in the scientific literature and the medicinal properties of pomegranate may be exerted by polyphenols found in the plant. This review shows the health benefits of oral intake of pomegranate. The most commonly reported beneficial activities of this plant are antioxidant, cardiovascular and antidiabetic effects. The polyphenol constituents of pomegranate may be responsible for its medicinal properties. Future research is needed to define the therapeutic effects of oral intake of this plant and the phytochemical compounds implicated in these activities.Keywords: Pomegranate, Polyphenols, Therapeutic effects, Antioxidant, Cardiovascular, Antidiabetic
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