Objective: To characterize the metabolic variation in neonatal hair samples associated with intrauterine growth discordance in dichorionic-diamniotic (DCDA) twins and to evaluate the effects of specific metabolic alterations on later neurobehavioural outcomes in infancy. Design: Cohort-based case-control study Setting: Peking University Third Hospital Population: DCDA twins with birth weight discordance(DCDA-D) and birthweight concordance (DCDA-C) within a twin cohort recruited between September 2017 and December 2018 in Beijing, China. Methods: A specific hair metabolic profile of 14 pairs of DCDA-D twins was revealed using gas chromatography-mass spectrometry by comparing that of 28 pairs of DCDA-C twins. Pearson’s correlation was used to assess the relationship between the neonatal hair metabolome and neurocognitive outcomes, assessed using the Ages and the Infant’s Stages Questionnaires, third edition (ASQ-3) at 2 or 3 years of age. Main outcome measure: neonatal hair metabolome and long-term neurodevelopment. Results: A total of seventeen hair metabolites were significantly different within DCDA-D twin pairs compared to DCDA-C twins. Particularly, reduced levels of cysteine, threonine, and leucine were identified in both the larger and smaller DCDA-D twins compared with DCDA-C twins. The deregulated metabolic pathways including cysteine, methionine, aminoacyl-tRNA, nicotinate, and nicotinamide metabolism biosynthesis pathways in DCDA-D groups were positively correlated with infant neurocognitive development at 2 or 3 years of age, especially in problem-solving domains. Conclusion: Neonatal hair metabolic variations in utero of growth discordance in DCDA twins may be associated with poor neurocognitive development. Metabolome profiles of hair may be novel predictors of infant neurodevelopment longitudinally.

Background: Primary bone marrow diffuse large B-cell lymphoma (PBM-DLBCL) is a rare hematological malignancy with a poor prognosis. The lack of a clear definition and unified diagnostic criteria for this disease in the WHO classification poses challenges for its diagnosis and management. Patients and Methods: To gain insights into the clinicopathological characteristics of PBM-DLBCL and explore prognostic factors, we conducted a study using data from our center and published literature spanning from 2001 to 2022. A total of 70 patients were included in our analysis. Results: Univariate analysis revealed that patients presenting with B symptoms and higher IPI scores tended to have a poorer prognosis, although statistical significance was not achieved (P>0.05). However, patients who attained a complete response (CR) after initial therapy exhibited better outcomes (P=0.007). Intensive treatment regimens demonstrated potential benefits over general treatment approaches. Additionally, our investigation suggested that rituximab-based chemotherapy was associated with improved prognoses compared to other general regimens. Conclusion: PBM-DLBCL is an aggressive disease with distinct clinical, pathological, and imaging features. It is crucial to understand the clinical characteristics of PBM-DLBCL, identify clinical risks in a timely manner, and determine appropriate treatment regimens.

Introduction: Primary tracheal carcinoma is a rare and challenging disease that presents significant diagnostic and therapeutic difficulties. Delayed diagnosis due to misinterpretation of airway obstruction symptoms often leads to poorer prognoses for patients. This study aimed to explore the clinical manifestations and multidisciplinary treatment approaches for primary tracheal carcinoma in Bangladesh, with a focus on recent advancements in diagnosis and treatment. Methods: A retrospective observational study was conducted at Bangladesh Specialized Hospital Limited, involving patients aged over 30 who were diagnosed with tracheal carcinoma and underwent multidisciplinary treatment. Data were collected through patient interviews and medical record reviews. Descriptive and inferential statistical analyses were performed to examine demographic characteristics, histological variations, tumor locations, clinical signs and symptoms, treatment approaches, and outcomes. Results: Thirteen patients were included in the study, with a mean age of 49.15±10.50 years. The most common histological variations were invasive squamous cell carcinoma and adenoid cystic carcinoma. The upper trachea was the most prevalent tumor location. Dyspnea, cough, and hemoptysis were the most frequently reported symptoms. Surgical interventions, such as definitive surgery and apple coring surgery, were the primary treatment modalities. Multidisciplinary approaches including Adjuvant / definitive Radiotherapy resulted in a low rate of local recurrence, and patients with successful treatment had better survival outcomes. Conclusion: This study provides insights into the demographic and clinical characteristics of primary tracheal carcinoma in Bangladesh and highlights the importance of a multidisciplinary treatment approach. Further research with larger sample sizes is needed to validate these findings and improve diagnostic and therapeutic strategies for this rare malignancy.

Successful Surgical Management of Symptomatic Antenatally Diagnosed Congenital Pulmonary Airway Malformation: A Case Report

The Doradidae fishes constitute one of the most diverse groups of Neotropical freshwater environments. Acanthodoradinae is the oldest lineage and the sister group to all other thorny catfishes, and it includes only the genus Acanthodoras. The diversity of Acanthodoras remains underestimated, and the use of complementary approaches, including genetic studies, is an important step to better characterize this diversity and the relationships among the species within the genus. Therefore, we conducted a comprehensive analysis using conventional cytogenetic techniques and physical mapping of three multigene families (18S and 5S ribosomal DNA [rDNA], U2 small nuclear DNA [snDNA]) and four microsatellite motifs, namely (AC)n, (AT)n, (GA)n, and (GATA)n, in two sympatric species from the Negro River: Acanthodoras cataphractus and Acanthodoras cf. polygrammus. We found significant differences in constitutive heterochromatin (CH) content, distribution of the microsatellite (AT)n, and the number of 5S rDNA and U2 snDNA sites. These differences may result from chromosome rearrangements and repetitive DNA dispersal mechanisms. Furthermore, the characterization of the diploid number (2n) of these Acanthodoras species enables us to propose 2n = 58 chromosomes as the plesiomorphic 2n state in Doradidae based on ancestral state reconstruction. Acanthodoradinae is the oldest lineage of the thorny catfishes, and knowledge about its cytogenetic patterns is crucial for disentangling the karyotype evolution of the whole group. Thus, this study contributes to the understanding of the mechanisms behind chromosome diversification of Doradidae and highlights the importance of Acanthodoradinae in the evolutionary history of thorny catfishes.

The hypothalamic-pituitary-adrenal (HPA) axis coordinates an organism’s response to environmental stress. The responsiveness and sensitivity of an offspring’s stress response may be shaped not only by stressors encountered in an organism’s early post-natal environment, but also by stressors in their parent’s environment. Yet, few studies have considered how stressors encountered in both of these early life environments may function together to impact the developing HPA axis. Here, we manipulated stressors in the parental and post-natal environments in a population of house sparrows (Passer domesticus) to assess the impact of these stressors on changes in DNA methylation in a suite of genes within the HPA axis. We found that nestlings that experienced early life stress across both life-history periods had higher DNA methylation in a critical HPA axis gene, the glucocorticoid receptor (NR3C1). In addition, we found that the life-history stage when stress was encountered impacted some genes (HSD11B1, NR3C1, and NR3C2) differently. We also found evidence for the mitigation of parental stress by post-natal stress (in HSD11B1 and NR3C2). Finally, by assessing DNA methylation in both the brain and the blood, we were able to evaluate cross-tissue patterns; while some differentially methylated regions were tissue-specific, we found cross-tissue changes in NR3C2 and NR3C1, suggesting that blood may be a potential biomarker for DNA methylation of specific genes. Our results provide a crucial first step in understanding the mechanisms by which early life stress in different life history periods contributes to changes in the epigenome of the HPA axis.

The identification of genetically distinct populations is central to the management and conservation of wild populations. Whole-genome-sequencing allows for high-resolution assessment of genetic structure, demographic connectivity and the impacts of selection acting on different parts of the genome. Here, we utilise population genomics to investigate the genetic structure of the Australasian snapper or Tāmure (Chrysophrys auratus), an ecologically, economically, and culturally important (taonga) marine fish. We analysed over four million high-quality SNPs obtained by whole-genome sequencing from 382 individuals collected across its New Zealand range. We identified two genetic clusters (an eastern and western cluster) with genetic disjunctions around on either side of the North Island of New Zealand. These genetic clusters do not match the current fisheries management areas. Pairwise-FST and ADMIXTURE analyses showed the presence of directional gene flow occurring at both genetic disjunctions from the East to the West cluster. We hypothesize that major ocean currents are limiting the dispersal of snapper at these genetic disjunctions. The heterogeneous coastal environment is also likely driving evolutionary change. A genome scan identified four significantly divergent genomic regions between genetic clusters. A diverse pattern of genetic variation in these regions implies that different evolutionary processes drive local adaptation in these clusters. Identification of candidate genes in these regions also provides a tentative connection to which traits may be under selection. Our results provide novel insights into New Zealand’s coastal environment influences evolutionary processes, and valuable information for effective management of the snapper fisheries.

Lepus oiostolus (L. oiostolus) is a species endemic to the Qinghai-Tibet Plateau. However, the absence of a reference genome limits genetic studies. Here, we report a high-quality L. oiostolus genome assembly, with scaffolds anchored to 24 chromosomes and a total assembled length of 2.80 Gb (contig N50 = 64.24 Mb). We found that transposable elements account for 49.84% of the genome, a total of 22,295 predicted protein-coding genes. Long interspersed nuclear elements (LINEs) constitute a high proportion of the genome, and their expansion is a key contributor to this species’s relatively large genome size. A total of 1,282 genes were found to have expanded into gene families. Comparative analyses indicated that L. oiostolus probably diverged from its close relatives Ochotona curzoniae and Ochotona princeps, approximately 53.1 million years ago (MYA). This study suggested that the Tipin gene enabled Lepus oiostolus to adapt to the high levels of ultraviolet radiation in the Qinghai-Tibet Plateau. As the first chromosome-level genome assembly of Lepus oiostolus, this study will provide a valuable genomic resource for future research on the evolution of the Leporidae.

As sequencing technology continues to rapidly improve, studies investigating the microbial communities of host organisms (i.e., microbiomes) are becoming not only more popular but also more financially accessible. Across many taxa, microbiomes can have important impacts on organismal health and fitness. To evaluate the microbial community composition of a particular microbiome, microbial DNA must be successfully extracted. Fecal samples are often easy to collect and are a good source of gut microbial DNA. However, in birds and reptiles, microbial DNA extractions from fecal matter have proven to be difficult due to high concentrations of uric acid, an inhibitor of DNA extractions. Here, we present a new microbial DNA extraction method that is highly effective for avian species and displays higher efficiency and consistency than other commonly used methodologies. Further, our method is also effective in extracting microbial DNA from oils collected from the avian preen gland. Preen oil chemicals are important for many aspects of avian life, and the biosynthesis of these chemicals is dependent on the preen gland microbial community. We expect our method will facilitate microbial DNA extractions from multiple avian microbiome reservoirs, which have previously proved difficult and expensive. Our method therefore increases the feasibility of future studies of avian host microbiomes.

Recent works indicate that the lipid composition of extracellular vesicles (EVs) can modify their biological functions and their incorporation into recipient cells. In particular high-fat diets affect EV biogenesis, EV lipid composition, EV targeting and consequently the cross-talk between tissues. This review connects different research topics to show that a vicious circle is established during the development of high-fat diet-induced obesity, connecting the alteration of lipid metabolism, the composition of extracellular vesicles and the spread of deleterious lipids between tissues, which participates in NAFLD/NASH and diabetes development. According to the studies described in this review, it is urgent to take an interest in this question as the modulation of EV lipid composition could be an important factor to take into account during the therapeutic management of patients suffering from metabolic syndrome and related pathologies such as obesity and diabetes. Furthermore, as lipid modification of EVs is a strategy currently being tested to enable better integration into their target tissue or cell, it is important to consider the impact of these lipid modifications on the homeostasis of these targets. KEY WORDS: extracellular vesicles, lipids, high-fat diets, NAFLD, NASH, diabetes obesity, metabolic syndrome RUNNING TITLE: Fat diets affect extracellular vesicle fate

The enemy release hypothesis (ERH) is the best-known hypothesis explaining high performance (e.g., rapid population growth) of exotic species. However, the current framing of the ERH does not explicitly link evidence of enemy release with exotic performance. This leads to uncertainty regarding the role of enemy release in biological invasions. Here we demonstrate that the effect of enemy release on exotic performance is the product of three factors: enemy impact, enemy diversity, and host adaptation. These factors are modulated by seven contexts: time since introduction, resource availability, phylogenetic relatedness of exotic and native species, host-enemy asynchronicity, number of introduction events, type of enemy, and strength of growth-defence trade-offs. ERH-focused studies frequently test different factors under different contexts, leading to inconsistent findings, which characterise current evidence for the ERH. For example, over 80% of meta-analyses fail to consider ecological contexts that can modulate study findings; we demonstrate this by re-analysing a recent ERH synthesis. Structuring the ERH around factors and contexts promotes generalisable predictions about when and where exotic species may benefit from enemy release, empowering effective management. Our mechanistic factor-context framework clearly lays out the evidence required to support the ERH, unifies many enemy-related invasion hypotheses and enhances predictive capacity.

Intraocular pressure monitoring and anesthesia management of a morbidly obese patient who underwent laparoscopic surgery in the Trendelenburg position: a case reportMikiko Tomino, Ryosuke Okuyama, and Ryoji MaedaDepartment of Anesthesiology, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji-shi, Tokyo 193-0998, JapanCorresponding author: Mikiko TominoDepartment of AnesthesiologyTokyo Medical University Hachioji Medical Center1163 Tatemachi, Hachioji-shi, Tokyo 193-0998, JapanTel.: +81-042-665-5611; Fax: +81-042-665-5639Email:m-tomino@tokyo-med.ac.jp

A rare case of aberrant origin of left and right vertebral artery from double aortic archZhuoma Xiongqiu1, Dou Yuan2#.1 Department of Pediatric Intensive Care Unit, West China Hospital, Sichuan University, Guoxuexiang 37th, 610041 Chengdu, Sichuan, P.R. China.2 Department of Cardiovascular Surgery, Cheng Du Shang Jin Nan Fu Hospital, West China Hospital of Sichuan University,Chengdu 610041, Sichuan Province, China.# Correspondence: Dou Yuan,, Chengdu, Sichuan, 610041, People’s Republic of China; fax: + 86 28 85422897; e-mail:yuandou123456789@aliyun.com .

The overlap between motor and cognitive symptoms resulting from posterior parietal cortex (PPC) and cerebellar lesions can mask their relative contribution in sensorimotor integration processes. This study aimed to identify distinguishing motor and cognitive features to disentangle PPC and cerebellar involvement in two sensorimotor-related functions: gait and body schema representation. Thirty healthy subjects were enrolled and randomly assigned to PPC or cerebellar stimulation. Sham stimulation and 1Hz repetitive Transcranial Magnetic Stimulation were delivered over P3 or cerebellum before balance, walking and distance estimation tasks. Each trial was repeated with eyes open (EO) and closed (EC). Gait spatiotemporal and kinematic variables were recorded by eight inertial measurement units. Instability increased in both groups after real stimulation vs. sham stimulation: PPC inhibition increased the instability in EC conditions, while cerebellar inhibition affected both EC and EO stability. Spatiotemporal variability increased after real stimulation (EC vs EO) in both groups but mostly affecting different parameters. Increased kinematic variability of ankle and knee angles was observed in both groups after real stimulation (EC vs. EO). Distance overestimation was observed after real stimulation (EC) only in the PPC group. Stability, gait variability and distance estimation parameters can be used to disentangle cerebellar and PPC sensorimotor integration deficits. Differential diagnosis efficiency can benefit from this methodological approach.

In uncertain environments in which resources fluctuate continuously, animals must permanently decide whether to exploit what they currently believe to be their best option, or instead explore potential alternatives in case better opportunities are in fact available. While such a trade-off has been extensively studied in pretrained animals facing non-stationary decision-making tasks, it is yet unknown how they progressively tune it while progressively learning the task structure during pretraining. Here, we compared the ability of different computational models to account for long-term changes in the behaviour of 24 rats while they learned to choose a rewarded lever in a three-armed bandit task across 24 days of pretraining. We found that the day-by-day evolution of rat performance and win-shift tendency revealed a progressive stabilization of the way they regulated the exploration-exploitation trade-off. We successfully captured these behavioural adaptations using a meta-learning model in which the exploration-exploitation trade-off is controlled by the animal's average reward rate.

In this article, the inverse problems for the wave equation in a medium in which multiple types of cavities and inclusion exist in a mixture are considered. From the point of view of the indicator function of the enclosure method, there are two types of heterogeneous parts:“minus group” and “plus group”. For example, cavities with the Dirichlet boundary condition belong to the minus group, while inclusions with smaller propagation velocity belong to the plus group. The heterogeneous part of the minus group gives a negative sign to the indicator function, and the heterogeneous part of the plus group gives a positive sign. In general, the presence of many types of heterogeneous parts causes cancellation of the sign of the indicator function. Such cases are referred to as “mixed cases”. Here we consider the case that the shortest length obtained from the indicator function is attained only by heterogeneous parts of the same group. This case is called the “mixed but separated case” and it is shown that the method of elliptic estimates developed by Ikehata works well. We also show that the case of a two-layered background medium with a flat layer can be considered in the same way as the case of a homogeneous background medium.

In this work, we consider a mathematical model of viscoelastic incompressible fluid governed by the Navier-Stokes-Voigt equations in a three dimensional thin domain Ω ε , with damping term and Tresca friction law. First, we give the problem statement and the weak variational formulation of the considered problem. Then we study the asymptotic analysis of the problem when a dimension of the domain tends to zero. The limit problem and the specific equation of Reynolds are obtained.

Purpose –The main purpose of this paper is to propose a numerical model which represents dynamic responses of elastic steel-concrete beams. Design/methodology/approach –The numerical model is based on the lumped system with the combination of transfer matrix method (TMM) and analog beam methods (ABM). The beams which are widely used in constructions of highway bridges are composed of an upper concrete slab and a lower steel beam, connected at the interface by shear transmitting studs. The field and point transfer matrices for the beam element of the elastic composite beams are derived. The present model is verified and is applied to study the dynamic response of elastic composite beams subjected to both, moving force or mass. The effects of shear stiffness between the upper slab and lower beam and moving load velocity on the steel-concrete beams deflection are shown. Findings –Results indicate that the maximum deflection in the composite beam subjected to moving load, is significantly affected by the level of interaction between sub-beams and by the load type and velocity. Originality/value – Recently, a numerical model based on the lumped system with the combination of the TMM and the ABM was proposed to study the response of elastic steel-concrete beams with partial interaction, limited to static loading solely. In this study, the current proposed model is developed to study the dynamic response of steel-concrete beams with partial interaction due to moving loads of various velocities. The advantage of the proposed model, unlike previous models that are based on the combination of (TMM) and (ABM), is the ability for studying the dynamic behavior of the elastic steel-concrete beams with various end and intermediate conditions and different types and velocities of moving loads.

Reaction-diffusion equations play important role in problems related to population dynamics, developmental biology, and phase-transition. For such equations, we propose a strong-form local (multiquadric) RBF method that gives sparse well-conditioned differentiation matrices with reduced computational cost and memory storage; thus, avoids solving dense ill-conditioned system matrices, an inherited drawback of strong-form global RBF methods if compared to the limitations of mesh-based methods. After spatial discretization of the time-dependent PDE problem by sparse differentiation matrices, the resultant system of ODEs can be stably integrated in time via a high-order and high-quality ODE solver. The proposed method is tested on two-dimensional Fisher-type equations for its geometric flexibility, accuracy, and efficiency. Unlike the mesh-based methods, the proposed local method works for arbitrary scattered data points and is equally effective for problems over non-rectangular domains. Some recommendations are also made for further efficient implementation of the proposed local multiquadric method.

We consider an alternative approach to investigate three-dimensional exterior mixed boundary value problems (BVP) for the steady state oscillation equations of the elasticity theory for isotropic bodies. The unbounded domain occupied by an elastic body, Ω − ⊂ R 3 , has a compact boundary surface S = ∂ Ω − , which is divided into two disjoint parts, the Dirichlet part S D and the Neumann part S N , where the displacement vector (the Dirichlet type condition) and the stress vector (the Neumann type condition) are prescribed respectively. Our new approach is based on the classical potential method and has several essential advantages compared with the existing approaches. We look for a solution to the mixed boundary value problem in the form of a linear combination of the single layer and double layer potentials with densities supported on the Dirichlet and Neumann parts of the boundary respectively. This approach reduces the mixed BVP under consideration to a system of boundary integral equations, which contain neither extensions of the Dirichlet or Neumann data nor the Steklov-Poincaré type operator involving the inverse of a special boundary integral operator, which is not available explicitly for arbitrary boundary surface. Moreover, the right-hand sides of the resulting boundary integral equations system are vector-functions coinciding with the given Dirichlet and Neumann data of the problem in question. We show that the corresponding matrix integral operator is bounded and coercive in the appropriate L 2 -based Bessel potential spaces. Consequently, the operator is invertible, which implies unconditional unique solvability of the mixed BVP in the class of vector-functions belonging to the Sobolev space [ W 2 , loc 1 ( Ω − ) ] 3 and satisfying the Sommerfeld-Kupradze radiation conditions at infinity. We also show that the obtained matrix boundary integral operator is invertible in the L p -based Besov spaces and prove that under appropriate boundary data a solution to the mixed BVP possesses C α -Hölder continuity property in the closed domain Ω − ‾ with α = 1 2 − ε , where ε>0 is an arbitrarily small number.

The upper Colorado River is a highly regulated system that provides habitat for federally listed species, disproportionate number of flora and fauna and is the water supply for the western United States. River regulation has led to wide scale channel narrowing. Over the last three decades dams have been operated with a more natural hydrograph for environmental reasons. We sought to use remote imagery from 1940-2022 to examine rates of channel narrowing in the pre-dam, post-dam, and environmental flows eras along three river reaches in Canyonlands National Park. We found an increase in the vegetated area along the Colorado River (above the confluence with the Green River) and the Green River since 1940. We documented a 6.12% and 4.00% narrowing in the post-dam period and a 19.51% and 6.49% narrowing in the environmental flows period on the Colorado and Green Rivers, respectively. The Cataract Canyon reach (Colorado River below the confluence) has been stable since 1966. All three river reaches showed the slowest period of narrowing in the last 16 years of environmental flows that coincided with a large peakflow in 2011. All three reaches showed a decrease in vegetated area after the 2011 flood, followed by an increase in vegetated area to similar levels to before the 2011 flood. Environmental flows that mimic the natural hydrograph may have slowed channel narrowing, but it is clear that periodic large peaks are also necessary. Managers must be careful that any environmental flows that take from the spring peak are carefully considered.

Purpose: To investigate the neural substrates underlying the fluency of future thoughts in episodic future thinking by investigating the functional connectivity of the brain. So far, the neural basis of the specificity of future representations has been studied, while there is a fair amount of evidence toward functions of fluency of future thoughts on various disorders and behaviors. Method: The resting-state fMRI data of fifteen right-handed adults (female=8, male=7) aged 25 to 40 years (M age=31.8.16, SD age=5.6) was analyzed to extract the graph theoretical measure of nodal degrees in the default mode network (DMN) nodes. The correlational analysis was conducted between the nodal degrees and the measure of fluency of the future thoughts examined by the personal future task (PFT). Results: Findings indicated a significant correlation between fluency of future thoughts and nodal degree of middle temporal, inferior parietal, and posterior cingulate gyri, as well as precuneus. Discussion and Conclusion: Brain areas delineated in this study were consistent with brain activations during the construction of future representations identified in previous studies, but not akin to areas related to the elaboration phase of future thinking. This could be due to the differences between the tasks measuring the fluency, rather than the specificity of future thoughts.

A document by Mahdi Rezapour. Click on the document to view its contents.

Title : Synovial Sarcoma of the Maxilla: A Challenging Diagnostic Case Report and Literature ReviewAbstract : Synovial sarcoma, a malignant mesenchymal tumor, is primarily associated with the extremities. Nevertheless, its appearance within the head and neck region, particularly in the maxillary area, is remarkably rare. This rarity underscores the significance of each case in unraveling the complexities of its behavior and management strategies. The core focus of this research is a detailed case report involving a 6-year-old female patient who presented with a conspicuous swelling in the left posterior maxilla. Subsequent incisional biopsy led to microscopic identification of malignant spindle cell proliferation, marked by dysplastic changes and abundant mitoses. Immunohistochemical analysis demonstrated negative reactivity for neural and muscular markers, while positive expression of Vimentin, Bcl-2, and TLE1. These morphological and immunohistochemical findings coalesced to definitively diagnose synovial sarcoma, substantiated by a notable 40% Ki67 proliferative index. The chosen treatment strategy encompassed surgery and radiotherapy, which yielded successful outcomes, with no recurrence observed during the one-year follow-up period. Beyond the specific case, this article undertakes a review of existing literature, meticulously analyzing nine similar cases reported in scholarly sources.Keywords : Case report, Head and neck, Maxilla, Synovial sarcoma